Abstract
Multi-cellular organisms such as humans contain hundreds of cell types that share the same genetic information (DNA sequences), and yet have different cellular traits and functions. While how genetic information is passed through generations has been extensively characterized, it remains largely obscure how epigenetic information encoded by chromatin regulates the passage of certain traits, gene expression states and cell identity during mitotic cell divisions, and even through meiosis. In this review, we will summarize the recent advances on molecular mechanisms of epigenetic inheritance, discuss the potential impacts of epigenetic inheritance during normal development and in some disease conditions, and outline future research directions for this challenging, but exciting field.
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Acknowledgements
This work was supported by the National Natural Science Foundation of China (31725015, 31830048 to Q.L. and 32000417 to W.D.), the Beijing Outstanding Young Scientist Program (BJJWZYJH01201910001005 to Q.L.), the National Key Research and Development Project of China (2019YFA0508903 to Q.L.), the China Postdoctoral Science Foundation (2020M670487 to W. D.), the Chinese Academy of Sciences (XDB 37010100 and QYZDY-SSW-SMC031 to B.Z.), the K. C. Wong educational foundation (GJTD-2020-06 to B.Z.) and the National Institutes of Health (R35 GM126910 to S.J. and R35 GM115018 to Z.Z.). We apologize that we could not cite all references because of space limitations.
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Du, W., Shi, G., Shan, CM. et al. Mechanisms of chromatin-based epigenetic inheritance. Sci. China Life Sci. 65, 2162–2190 (2022). https://doi.org/10.1007/s11427-022-2120-1
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DOI: https://doi.org/10.1007/s11427-022-2120-1