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Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob/ob mice

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Abstract

The antidiabetic effects of a hot water extract of the stems of Salacia chinensis (SCE) were evaluated in vivo in ob/ob mice (genetically obese hyperglycemic mice). Administration of dietary feed containing 0.20 and 0.50% of SCE for 23 days to ob/ob mice significantly suppressed the elevation of both blood glucose and HbA1c levels, without significantly changing body weight and food intake. To characterize the antidiabetic effects of the thiosugar sulfonium constituent neokotalanol (1), which has potent α-glucosidase inhibitory activity, we performed a similar in vivo study. HbA1c levels were significantly suppressed in ob/ob mice after the administration of dietary feed containing 0.0003% of neokotalanol (1) for 20 days. These results indicate that SCE and neokotalanol (1) are potential leads for the development of novel antidiabetic agents.

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Acknowledgements

This work was supported by MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2014–2018, S1411037 (T.M.); and a Grant-in-aid for Scientific Research (KAKENHI), 18K06739 (K.N.), 16K08313 (O.M.), and 18K06726 (T.M.).

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Authors and Affiliations

  1. Central R&D Laboratory, Kobayashi Pharmaceutical Co., Ltd., 1-30-3, Toyokawa, Ibaraki, Osaka, 567-0057, Japan

    Masakazu Kobayashi, Junji Akaki, Yasuyo Yamaguchi & Hiroo Yamasaki

  2. Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan

    Junji Akaki, Kiyofumi Ninomiya, Masayuki Yoshikawa, Osamu Muraoka & Toshio Morikawa

  3. Antiaging Center, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan

    Kiyofumi Ninomiya, Osamu Muraoka & Toshio Morikawa

  4. Faculty of Science and Technology, Rajamangala University of Technology Srivijaya, Thungyai, Nakhon Si Thammarat, 80240, Thailand

    Yutana Pongpiriyadacha

Authors
  1. Masakazu Kobayashi
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  2. Junji Akaki
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  3. Yasuyo Yamaguchi
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  4. Hiroo Yamasaki
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  5. Kiyofumi Ninomiya
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  6. Yutana Pongpiriyadacha
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  7. Masayuki Yoshikawa
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  8. Osamu Muraoka
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  9. Toshio Morikawa
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Correspondence to Masakazu Kobayashi or Toshio Morikawa.

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Conflict of interest

MK., J.A., Y.Y., and H.Y. are employees of Kobayashi Pharmaceutical Co. Ltd. K.N., Y.P., M.Y., O.M., and T.M. have no conflict of interest.

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Kobayashi, M., Akaki, J., Yamaguchi, Y. et al. Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob/ob mice. J Nat Med 73, 584–588 (2019). https://doi.org/10.1007/s11418-019-01311-w

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  • DOI: https://doi.org/10.1007/s11418-019-01311-w

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