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Mutagenetic and anti-allergic studies for evaluation of extracts of Coptis Rhizome produced by an artificial hydroponic system

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Abstract

As a part of the investigation of the safety and efficacy of the cultivated Coptis japonica rhizome extracts using an artificial hydroponic cultivation system, the mutagenetic and anti-allergic activities were evaluated. Some extracts of commercial crude drugs of Coptis sp. were also evaluated for the comparison. None of the extracts showed a significant mutagenicity in Salmonella typhimurium TA102 by the Ames tests, but all the extracts showed in S. typhimurium TA98. The extracts of the hydroponically cultivated rhizomes showed anti-allergic activities against contact hypersensitivity as well as those of commercial crude drugs of Coptis sp. These results suggested the potential of the hydroponically cultivated rhizomes as one of the alternative sources for the medicinal usage.

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Acknowledgements

This study was supported by a Health and Labour Sciences Research Grant from the Ministry of Health, Labour and Welfare of Japan, a Grant from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The authors would like to thank the Japan Kampo Medicines Manufacturers Association and Tokyo Crude Drug Association for providing the commercial Coptis crude drugs.

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Authors and Affiliations

  1. National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan

    Hiroshi Akiyama, Hajime Takiguchi, Keiichi Sugiyama & Takaaki Taguchi

  2. Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya, 468-8503, Japan

    Mitsuhiko Nose, Riho Tsutsui & Shinsuke Hisaka

  3. Tsukuba Division, Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition, 1-2 Hachimandai, Tsukuba, Ibaraki, 305-0843, Japan

    Hiroyuki Fuchino, Takayuki Inui, Noriaki Kawano, Nobuo Kawahara & Kayo Yoshimatsu

  4. Kajima Technical Research Institute, Kajima Corporation, 19-1, Tobitakyu 2-chome, Chofushi, Tokyo, 182-0036, Japan

    Tadashi Kudo

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  1. Hiroshi Akiyama
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  2. Mitsuhiko Nose
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  9. Noriaki Kawano
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  12. Nobuo Kawahara
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  13. Kayo Yoshimatsu
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Correspondence to Hiroshi Akiyama.

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Akiyama, H., Nose, M., Takiguchi, H. et al. Mutagenetic and anti-allergic studies for evaluation of extracts of Coptis Rhizome produced by an artificial hydroponic system. J Nat Med 73, 608–613 (2019). https://doi.org/10.1007/s11418-019-01288-6

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  • DOI: https://doi.org/10.1007/s11418-019-01288-6

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