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A novel steroidal alkaloid from Fritillaria shuchengensis

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Abstract

A novel steroidal alkaloid, suchengbeisine (1), along with two known steroidal alkaloids, N-oxide of verticinone (2) and zhebeininoside (3), were isolated from the bulbs of Fritillaria shuchengensis S. C. Chen et S. F. Yin. The structures of these compounds were elucidated by intensive spectroscopic methods, including NMR, IR, CD and MS.

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References

  1. Jiang Y, Li HJ, Li P, Cai ZH, Ye WC (2005) Steroidal alkaloids from the bulbs of Fritillaria puqiensis. J Nat Prod 68:264–267

    Article  PubMed  CAS  Google Scholar 

  2. Yu XL, Ji H, Wang CL, Li P (2000) Advances in studies on pharmacological effects of plants from Fritillaria L. Chin Tradit Herb Drugs 31:313–315

    Google Scholar 

  3. Zhu WF, Liao MX (2008) The research progress of iso-steroidal alkaloids. Asia Pac Trad Med 4:40–43

    Google Scholar 

  4. Zhang SH, Li RP, Chen P (1993) Study on Fritillarias shuchengensis as a drug used to treat acute and chronic bronchitis. Anhui Med J 14:55–57

    CAS  Google Scholar 

  5. Wang XJ, Zhou XL, Zhu HM, Huang S, Chen AX (2008) Study on the chemical constituents of Fritillaria shuchengensis. Nat Prod Res Dev 20:11–13

    Google Scholar 

  6. Yu SC, Xiao PG (1990) Studies on chemical constituents of Fritillaria unibracteata I. Chin Trad Med Herb 21:2–6

    CAS  Google Scholar 

  7. Wang FP, Zhong R, Tang XY (1992) Revision of structure of peimisine. Acta Pharm Sin 27:273–278

    CAS  Google Scholar 

  8. Abdel-Kader MS, Bahler BD, Malone S, Werkhoven MC, van Troon F, David, Wisse JH, Bursuker I, Neddermann KM, Mamber SW, Kingston DG (1998) DNA-damaging steroidal alkaloids from Eclipta alba from the Surinam rainforest. J Nat Prod 61:1202–1208

  9. Moiseeva GP, Shakirov R, Yunusov SY (1976) Circular dichroism of some steroid alkaloids. Chem Nat Compd 12:563–565

    Google Scholar 

  10. Wang FP, Zhang GR, Tang XY, Wang JZ (1994) Imperialine β-N-oxide and its 2D NMR spectra. Chin J Org Chem 14:548–552

    CAS  Google Scholar 

  11. Kitajima J, Noda N, Ida Y, Miyahara K, Kawasaki T (1981) Steroid alkaloids of fresh bulbs of Fritillaria thunbergii Miq. and of crude drug “Bai-Mo” prepared therefrom. Heterocycles 15:791–796

    Google Scholar 

  12. Zhang JX, Lao AN, Xu RS (1993) Studies on chemical constituents of Fritillaria thunbergii Miq. J Integr Plant Biol 25:238–241

    Google Scholar 

  13. Chou TC, Motzer RJ, Tong Y, Bosl GJ (1994) Computerized quantitation of synergism and antagonism of taxol, topetecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. J Natl Cancer Inst 86:1517–1524

    Article  PubMed  CAS  Google Scholar 

  14. Buttke TM, McCubrey JA, Owen TC (1993) Use of an aqueous soluble tetrazolium/formazan assay to measure viability and proliferation of lymphokine-dependent cell lines. J Immunol Methods 157:233–240

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This research work was financially supported by the New Century Talents Scheme of the Ministry of Education (NCET-08-0820), the Fundamental Research Funds for Central Universities (SWJTU2010ZT09), and the National Natural Science Foundation of China (21142004, 31171695).

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Correspondence to Xian-li Zhou.

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Huang, S., Zhou, Xl., Wen, J. et al. A novel steroidal alkaloid from Fritillaria shuchengensis . J Nat Med 67, 647–651 (2013). https://doi.org/10.1007/s11418-012-0702-7

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  • DOI: https://doi.org/10.1007/s11418-012-0702-7

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