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A glycerol α-d-glucuronide and a megastigmane glycoside from the leaves of Guettarda speciosa L.

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Abstract

From the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Guettarda speciosa L., two new compounds (1, 2) were isolated together with six known compounds. Spectroscopic analysis of 1 and 2 established their structures to be derivatives of a glycerol α-glucuronide and a megastigmane glycoside, respectively. HPLC analysis of the hydrolyzate of 1 confirmed the presence of d-glucuronic acid in the structure, and the modified Mosher’s method established the absolute structure of 2.

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Acknowledgments

The authors are grateful for access to the superconducting NMR instrument (JEOL JNM α-400) at the Analytical Center of Molecular Medicine of the Hiroshima University Faculty of Medicine and an Applied Biosystem QSTAR XL system ESI (Nano Spray)–MS at the Analysis Center of Life Science of the Graduate School of Biomedical Sciences, Hiroshima University. This work was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan, the Japan Society for the Promotion of Science, and the Ministry of Health, Labour and Welfare. Thanks are also due to the Research Foundation for Pharmaceutical Sciences and the Takeda Science Foundation for their financial support.

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Authors and Affiliations

  1. Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan

    Wen-Hu Cai, Katsuyoshi Matsunami & Hideaki Otsuka

  2. Subtropical Field Science Center, Faculty of Agriculture, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Nakagami-gun, Okinawa, 903-0213, Japan

    Takakazu Shinzato

  3. Faculty of Pharmacy, Yasuda Women’s University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima, 731-0153, Japan

    Yoshio Takeda

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  1. Wen-Hu Cai
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  2. Katsuyoshi Matsunami
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  3. Hideaki Otsuka
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  4. Takakazu Shinzato
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Correspondence to Hideaki Otsuka.

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Cai, WH., Matsunami, K., Otsuka, H. et al. A glycerol α-d-glucuronide and a megastigmane glycoside from the leaves of Guettarda speciosa L.. J Nat Med 65, 364–369 (2011). https://doi.org/10.1007/s11418-010-0484-8

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