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Neuro-amelioration of Ficus lyrata (fiddle-leaf fig) extract conjugated with selenium nanoparticles against aluminium toxicity in rat brain: relevance to neurotransmitters, oxidative, inflammatory, and apoptotic events

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Abstract

Aluminium is a non-essential metal, and its accumulation in the brain is linked with potent neurotoxic action and the development of many neurological diseases. This investigation, therefore, intended to examine the antagonistic efficacy of Ficus lyrata (fiddle-leaf fig) extract (FLE) conjugated with selenium nanoparticles (FLE-SeNPs) against aluminium chloride (AlCl3)-induced hippocampal injury in rats. Rats were allocated to five groups: control, FLE, AlCl3 (100 mg/kg), AlCl3 + FLE (100 mg/kg), and AlCl3 + FLE-SeNPs (0.5 mg/kg). All agents were administered orally every day for 42 days. The result revealed that pre-treated rats with FLE-SeNPs showed markedly lower acetylcholinesterase and Na+/K+-ATPase activities in the hippocampus than those in AlCl3 group. Additionally, FLE-SeNPs counteracted the oxidant stress-mediated by AlCl3 by increasing superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione contents in rat hippocampus. Besides, the formulated nanoparticles decreased the hippocampal malondialdehyde, carbonyl protein, and nitric oxide levels of AlCl3-exposed animals. Furthermore, FLE-SeNPs attenuated neural tissue inflammation, as demonstrated by decreased interleukin-1 beta, interleukin-6, nuclear factor kappa B, and glial fibrillary acidic protein. Remarkable anti-apoptotic action was exerted by FLE-SeNPs by increasing B cell lymphoma 2 and decreasing caspase-3 and Bcl-2-associated-X protein in AlCl3-exposed rats. The abovementioned results correlated well with the hippocampal histopathological findings. Given these results, SeNPs synthesized with FLE imparted a remarkable neuroprotective action against AlCl3-induced neurotoxicity by reversing oxidative damage, neuronal inflammation, and apoptosis in exposed rats.

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Funding

This research has been funded by the Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2023R23), Princess Nourah bint Abdulrahman Uinvsrsity Riyadh, Saudi Arabia.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt

    Sara S. Elganzoury, Mohamed S. Abdelfattah & Mohga S. Abdalla

  2. Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt

    Ola A. Habotta

  3. Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia

    Manal El-khadragy

  4. Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo, Egypt

    Ahmed E. Abdel Moneim

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  1. Sara S. Elganzoury
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  4. Manal El-khadragy
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Contributions

Mohga S. Abdalla, Ahmed E. Abdel Moneim, and Mohamed S. Abdelfattah: conceptualization and methodology. Sara S. Elganzoury and Ola A. Habotta: data curation and analysis. Manal F. El-Khadragy and Ola A. Habotta: resources, validation, writing — original draft preparation, and writing — reviewing and editing.

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Correspondence to Ahmed E. Abdel Moneim.

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The experimental protocol was reviewed and approved by the Committee of Research Ethics for Laboratory Animal Care, Department of Zoology and Entomology, Faculty of Science, Helwan University (Cairo, Egypt; approval no, HU2021/Z/AES0321-01).

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Elganzoury, S.S., Abdelfattah, M.S., Habotta, O.A. et al. Neuro-amelioration of Ficus lyrata (fiddle-leaf fig) extract conjugated with selenium nanoparticles against aluminium toxicity in rat brain: relevance to neurotransmitters, oxidative, inflammatory, and apoptotic events. Environ Sci Pollut Res 30, 65822–65834 (2023). https://doi.org/10.1007/s11356-023-26935-0

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