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In vitro analysis of green synthesized CuO nanoparticles using Tanacetum parthenium extract for multifunctional applications

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Abstract

Tanacetum parthenium L. is a popular traditional medicinal plant that the role of presence of particular phytochemical compounds are still unconsidered particularly in the bio-nano researches. Here, for the first time, the green fabrication of CuO NPs using Tanacetum parthenium L. extract was performed and assessed for the antimicrobial, cytotoxicity, and dye degradation activities. Characterization of CuO NPs was done by UV-visible spectra, XRD, FT-IR, TEM, and EDX. The synthesized CuO NPs possess a crystalline nature, a functional group that resembles T. parthenium, with a spherical shape particle with an average size of 28 nm. EDX confirmed CuO NPs formation. The CuO NPs showed excellent antimicrobial activity against tested microorganisms. The cytotoxicity of CuO NPs was demonstrated the concentration-dependent inhibition of the growth against both cancer and normal cell lines. The results exhibited concentration-dependent inhibition of the growth of Hela, A 549, and MCF7 cancer cells (IC50 = 65.0, 57.4, and 71.8 µg/mL, respectively), which were statistically significant comparing control cells (IC50 = 226.1 µg/mL). Furthermore, we observed that CuO NPs-induced programmed cell death in the cancer cells were mediated with the downregulation of Bcl2 and upregulation of bax, caspase-3. CuO NPs were verified to be a superb catalyst as they had excellent activity for the degradation of 99.6%, 98.7%, 96.6%, and 96.6% of Congo red, methylene blue, methylene orange, and rhodamine B as industrial dyes in 3, 6.5, 6.5, and 6.5 min, respectively. Overall, the present study nominates T. parthenium as a proper bio-agent in the biosynthesis of CuO NPs with powerful catalytic and antimicrobial activities as well as a cancer treatment.

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Authors and Affiliations

  1. Department of Microbial Biotechnology, Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran

    Mojtaba Ranjbar

  2. Farzanegan Campus, Semnan University, Semnan, Iran

    Fatemeh Khakdan

  3. Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore, India

    Amitava Mukherjee

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  2. Fatemeh Khakdan
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  3. Amitava Mukherjee
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Contributions

M. R. designed the research and interpreted the data. M. R. and F. Kh. conceived the experiments and collected the experimental materials. M. R. supervised the experiments. M. R., F. Kh., and A. M. wrote the manuscript. All authors reviewed and approved the manuscript for submission.

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Correspondence to Mojtaba Ranjbar.

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Ranjbar, M., Khakdan, F. & Mukherjee, A. In vitro analysis of green synthesized CuO nanoparticles using Tanacetum parthenium extract for multifunctional applications. Environ Sci Pollut Res 30, 60180–60195 (2023). https://doi.org/10.1007/s11356-023-26706-x

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