Abstract
To explore the relationship between perinatal exposure to endocrine-disrupting chemicals and the male reproductive system of F3 generation, and to evaluate the toxicological effects of endocrine-disrupting chemicals on the reproductive system of F3 generation male rodents. PubMed and Web of Science databases were searched to obtain the studies; overall risk ratios (RRs) with 95% confidence intervals (95% CIs) were used to evaluate the relationship between exposure to endocrine-disrupting chemicals and reproductive system damage in F3 generation male rodents. Nine studies were included for analysis. Endocrine-disrupting chemicals are significantly associated with the reproductive system of male rodents of F3 generation, especially the testis (RR = 3.13, 95% CI: 2.05, 4.76), prostate (RR = 2.26, 95% CI: 1.27, 4.00), and kidney (RR = 2.83, 95% CI: 1.77, 4.52), but the current analysis does not prove that EDCs are the adverse factors for puberty abnormalities. The results indicated that the overall associations between atrazine (RR = 3.06, 95% CI: 1.10, 8.51, P = 0.032), DDT (RR = 6.26, 95% CI: 1.56, 25.08, P = 0.010), pesticide and insect repellent mixture (permethrin and DEET) (RR = 2.23, 95% CI: 1.34, 3.69, P = 0.002), and vinclozolin (RR = 4.71, 95% CI: 2.74, 8.10, P = 0.000) and reproductive system damage in F3 generation male rodents were statistically significant. Our study indicated that EDCs have an atavistic effect on the male reproductive system, and we should pay attention to the long-term effects of environmental exposure to endocrine disruptors in future generations.
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All data generated and analyzed during this study are included in this published article (and its supplementary information files).
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This work was supported by the University Natural Science Research Project of Anhui Province (KJ2018A0165) and by the Nature Science Research Project of Anhui Province (NO. 2108085MH305).
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Huan He and Yu Wei had the idea for the article. Huan He, Wenfeng Geng, and Wenjing Chen reviewed the literature. Huan He, Yu Wei, and Taifa Zhang checked and managed the data. Huan He and Yu Wei performed data analysis. Huan He, Yu Wei, and Wenfeng Geng drafted the manuscript. Jinxia Zhai, Wenfeng Geng, and Taifa Zhang provided expert reviews of the manuscript and reviewed and approved the manuscript. All authors contributed to the research article and approved the final version.
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He, H., Chen, W., Wei, Y. et al. Effects of perinatal exposure to endocrine-disrupting chemicals on the reproductive system of F3 generation male rodents: a meta-analysis. Environ Sci Pollut Res 29, 33218–33229 (2022). https://doi.org/10.1007/s11356-021-18338-w
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DOI: https://doi.org/10.1007/s11356-021-18338-w