Abstract
Increasing entrance of aluminum chloride (AlCl3) in many fields exposes human beings to its biotoxicity. Thereby, the present study assesses the potential ameliorative role of curcumin phytosome (CP) on AlCl3-induced hepatotoxicity. Rats were divided into four groups (n = 6): group 1 served as control; group 2 received CP (200 mg CP/kg b.wt) for 21 days; group 3 injected three doses of AlCl3 (30 mg/kg/body weight) every 5 days intraperitoneally; group 4 received CP for 7 days prior to AlCl3 and then received CP concurrently with AlCl3 for another 14 days. AlCl3 markedly increased (P < 0.05) the concentrations of AST, ALT, ALP, LDH, total bilirubin, and LPO as well as depleted (P < 0.05) albumin, GSH, SOD, and GPx stores in comparison to the control group. These biochemical alterations supported by the lesion observed in histological sections, increasing the expression of caspase-3 and decreasing the expression of Bcl-2. Treatment with CP modulates the hepatic dysfunction, boosting the endogenous antioxidant status, downregulating the expression of caspase-3, and upregulating the expression of Bcl-2. This hepatic ameliorative effect may be mediated by the ability of CP to repair the oxidant/antioxidant equilibrium rather than its ability to suppress apoptosis.
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The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University, Abha, KSA for funding this work through Research Group Project under grant number R.G.P.1–117–40.
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The experimental protocols using the animals were conducted in accordance with the Guide for the Care and Use of Laboratory Animals (8th edition) and approved by the scientific committee of Cairo University, Egypt, with approval number of CU/I/F/51/18.
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Al-Kahtani, M., Abdel-Daim, M.M., Sayed, A.A. et al. Curcumin phytosome modulates aluminum-induced hepatotoxicity via regulation of antioxidant, Bcl-2, and caspase-3 in rats. Environ Sci Pollut Res 27, 21977–21985 (2020). https://doi.org/10.1007/s11356-020-08636-0
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DOI: https://doi.org/10.1007/s11356-020-08636-0