Abstract
Pharmaceutical and personal care products (PPCPs) have gained attention in recent years due to their continuous discharge in natural waters. Their persistence in the environment has impacted flora, fauna and human being worldwide. One of the most common PPCPs is caffeine (1, 3, 7-trimethylxanthine) which acts as a stimulant to the central nervous system in humans and is found in nature in about 60 plant species, especially in coffee, tea and cacao plants. Here we discuss the evidence with respect to caffeine occurrence, its persistence and remediation in light of increasing knowledge and the impact of caffeine on the environment. Daily intake of caffeine around the world is found to increase due to the frequent introduction of new caffeinated beverages as well as increased consumption of coffee, tea and carbonated soft drinks, which has led to increase in its concentration in water bodies including agricultural soil. The caffeine concentration in different water system, studied by various authors is also described. Diverse effects of the use of caffeine on several organisms including humans are also briefly presented. Therefore, urgent attention for the removal of caffeine and its derivatives is the need of the hour. Various methods described in literature for caffeine degradation/removal is also presented. Another widely used technique in environmental remediation is molecular imprinting (MIP); however, only few MIPs have been demonstrated for caffeine which is also discussed. Regular monitoring can be useful to control toxic effects of caffeine.

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Abreu RV, Silva-Oliveira EM, Moraes MFD et al (2011) Chronic coffee and caffeine ingestion effects on the cognitive function and antioxidant system of rat brains. Pharmacol Biochem Behav 99:659–664. https://doi.org/10.1016/j.pbb.2011.06.010
Aguirre-Martínez GV, Buratti S, Fabbri E et al (2013a) Stability of lysosomal membrane in Carcinus maenas acts as a biomarker of exposure to pharmaceuticals. Environ Monit Assess 185:3783–3793. https://doi.org/10.1007/s10661-012-2827-2
Aguirre-Martínez GV, Buratti S, Fabbri E et al (2013b) Using lysosomal membrane stability of haemocytes in Ruditapes philippinarum as a biomarker of cellular stress to assess contamination by caffeine, ibuprofen, carbamazepine and novobiocin. J Environ Sci (China) 25:1408–1418. https://doi.org/10.1016/S1001-0742(12)60207-1
Al-Qaim FF, Mussa ZH, Othman MR, Abdullah MP (2015) Removal of caffeine from aqueous solution by indirect electrochemical oxidation using a graphite-PVC composite electrode: A role of hypochlorite ion as an oxidising agent. J Hazard Mater 300:387–397. https://doi.org/10.1016/j.jhazmat.2015.07.007
Al-Qaim FF, Mussa ZH, Yuzir A (2018) Development and validation of a comprehensive solid-phase extraction method followed by LC-TOF/MS for the analysis of eighteen pharmaceuticals in influent and effluent of sewage treatment plants. Anal Bioanal Chem 410:4829–4846. https://doi.org/10.1007/s00216-018-1120-9
Álvarez PM, Jaramillo J, López-Piñero F, Plucinski PK (2010) Preparation and characterization of magnetic TiO2 nanoparticles and their utilization for the degradation of emerging pollutants in water. Appl Catal B Environ 100:338–345. https://doi.org/10.1016/j.apcatb.2010.08.010
Angelucci MEM, Vital MABF, Cesário C et al (1999) The effect of caffeine in animal models of learning and memory. Eur J Pharmacol 373:135–140. https://doi.org/10.1016/S0014-2999(99)00225-3
Angelucci MEM, Cesário C, Hiroi RH et al (2002) Caffeine effect on Morris water maze. Braz J Med Biol Res 35:1201–1208
Anumol T, Vijayanandan A, Park M et al (2016) Occurrence and fate of emerging trace organic chemicals in wastewater plants in Chennai, India. Environ Int 92–93:33–42. https://doi.org/10.1016/j.envint.2016.03.022
Archana G, Dhodapkar R, Kumar A (2016) Offline solid-phase extraction for preconcentration of pharmaceuticals and personal care products in environmental water and their simultaneous determination using the reversed phase high-performance liquid chromatography method. Environ Monit Assess:188. https://doi.org/10.1007/s10661-016-5510-1
Archana G, Dhodapkar R, Kumar A (2017) Ecotoxicological risk assessment and seasonal variation of some pharmaceuticals and personal care products in the sewage treatment plant and surface water bodies (lakes). Environ Monit Assess 189:1–18. https://doi.org/10.1007/s10661-017-6148-3
Arfanis MK, Adamou P, Moustakas NG et al (2017) Photocatalytic degradation of salicylic acid and caffeine emerging contaminants using titania nanotubes. Elsevier B.V
Asghar MA, Zhu Q, Sun S et al (2018) Suspect screening and target quantification of human pharmaceutical residues in the surface water of Wuhan, China, using UHPLC-Q-Orbitrap HRMS. Sci Total Environ 635:828–837. https://doi.org/10.1016/j.scitotenv.2018.04.179
Ashengroph M (2017) Salinivibrio costicola GL6, a novel isolated strain for biotransformation of caffeine to theobromine under hypersaline conditions. Curr Microbiol 74:34–41. https://doi.org/10.1007/s00284-016-1148-z
Astrup A, Toubro S, Christensen NJ, Quaade F (1992) Pharmacology of thermogenic drugs. Am J Clin Nutr 55:246–248. https://doi.org/10.1093/ajcn/55.1.246s
Balakrishna K, Rath A, Praveenkumarreddy Y et al (2017) A review of the occurrence of pharmaceuticals and personal care products in Indian water bodies. Ecotoxicol Environ Saf 137:113–120. https://doi.org/10.1016/j.ecoenv.2016.11.014
Banerjee P, Ali Z, Levine B, Fowler DR (2014) Fatal caffeine intoxication: a series of eight cases from 1999 to 2009. J Forensic Sci 59:865–868. https://doi.org/10.1111/1556-4029.12387
Beckford K, Grimes CA, Riddell LJ (2015) Australian children’s consumption of caffeinated, formulated beverages: a cross-sectional analysis health behaviour, health promotion and society. BMC Public Health 15:1–10. https://doi.org/10.1186/s12889-015-1443-9
Benotti MJ, Brownawell BJ (2007) Distributions of pharmaceuticals in an urban estuary during both dry- and wet-weather conditions. Environ Sci Technol 41:5795–5802. https://doi.org/10.1021/es0629965
Biel-Maeso M, Baena-Nogueras RM, Corada-Fernández C, Lara-Martín PA (2018) Occurrence, distribution and environmental risk of pharmaceutically active compounds (PhACs) in coastal and ocean waters from the Gulf of Cadiz (SW Spain). Sci Total Environ 612:649–659. https://doi.org/10.1016/j.scitotenv.2017.08.279
Bonsignore A, Sblano S, Pozzi F et al (2014) A case of suicide by ingestion of caffeine. Forensic Sci Med Pathol 10:448–451. https://doi.org/10.1007/s12024-014-9571-6
Brodin T, Fick J, Jonsson M, Klaminder J (2013) Dilute concentrations of a psychiatric drug alter behaviour of fish from natural populations. Science (80- ) 339:814–815. https://doi.org/10.1126/science.1226850
Brozinski JM, Lahti M, Meierjohann A et al (2013) The anti-inflammatory drugs diclofenac, naproxen and ibuprofen are found in the bile of wild fish caught downstream of a wastewater treatment plant. Environ Sci Technol 47:342–348. https://doi.org/10.1021/es303013j
Brumovský M, Bečanová J, Kohoutek J et al (2017) Contaminants of emerging concern in the open sea waters of the Western Mediterranean. Environ Pollut 229:976–983. https://doi.org/10.1016/j.envpol.2017.07.082
Bruton T, Alboloushi A, De La Garza B et al (2010) Fate of caffeine in the environment and ecotoxicological considerations. ACS Symp Ser 1048:257–273. https://doi.org/10.1021/bk-2010-1048.ch012
Carlos L, Mártire DO, Gonzalez MC et al (2012) Photochemical fate of a mixture of emerging pollutants in the presence of humic substances. Water Res 46:4732–4740. https://doi.org/10.1016/j.watres.2012.06.022
Castellano, C (1976) Effects of caffeine on discrimination learning, consolidation, and learned behavior in mice.Psychopharmacology (Berl) 48:255–260. https://doi.org/10.1007/BF00496858
Chau HTC, Kadokami K, Duong HT et al (2018) Occurrence of 1153 organic micropollutants in the aquatic environment of Vietnam. Environ Sci Pollut Res 25:7147–7156. https://doi.org/10.1007/s11356-015-5060-z
Cheong WJ, Yang SH, Ali F (2013) Molecular imprinted polymers for separation science: a review of reviews. J Sep Sci 36:609–628. https://doi.org/10.1002/jssc.201200784
Christenson T (2008) Fish on morphine: protecting Wisconsin’s natural resources through a comprehensive plan for proper disposal of pharmaceuticals. Wis L Rev 1–54
Comeau F, Surette C, Brun GL, Losier R (2008) The occurrence of acidic drugs and caffeine in sewage effluents and receiving waters from three coastal watersheds in Atlantic Canada. Sci Total Environ 396:132–146. https://doi.org/10.1016/j.scitotenv.2008.02.031
Crippa A, Discacciati A, Larsson SC et al (2014) Coffee consumption and mortality from all causes, cardiovascular disease, and cancer: a dose-response meta-analysis. Am J Epidemiol 180:763–775. https://doi.org/10.1093/aje/kwu194
D’Alessio M, Onanong S, Snow DD, Ray C (2018) Occurrence and removal of pharmaceutical compounds and steroids at four wastewater treatment plants in Hawai’i and their environmental fate. Sci Total Environ 631–632:1360–1370. https://doi.org/10.1016/j.scitotenv.2018.03.100
Dafouz R, Cáceres N, Rodríguez-Gil JL et al (2018) Does the presence of caffeine in the marine environment represent an environmental risk? A regional and global study. Sci Total Environ 615:632–642. https://doi.org/10.1016/j.scitotenv.2017.09.155
Dalmázio I, Santos LS, Lopes RP et al (2005) Advanced oxidation of caffeine in water: on-line and real-time monitoring by electrospray ionization mass spectrometry. Environ Sci Technol 39:5982–5988. https://doi.org/10.1021/es047985v
Dash SS, Gummadi SN (2006) Catabolic pathways and biotechnological applications of microbial caffeine degradation. Biotechnol Lett 28:1993–2002. https://doi.org/10.1007/s10529-006-9196-2
de Sousa DNR, Mozeto AA, Carneiro RL, Fadini PS (2018) Spatio-temporal evaluation of emerging contaminants and their partitioning along a Brazilian watershed. Environ Sci Pollut Res 25:4607–4620. https://doi.org/10.1007/s11356-017-0767-7
Deo RP (2014) Pharmaceuticals in the surface water of the USA: a review. Curr Environ Heal Reports 1:113–122. https://doi.org/10.1007/s40572-014-0015-y
Egea-Corbacho A, Gutiérrez S, Quiroga JM (2019) Removal of emerging contaminants from wastewater through pilot plants using intermittent sand/coke filters for its subsequent reuse. Sci Total Environ 646:1232–1240. https://doi.org/10.1016/j.scitotenv.2018.07.399
Elhalil A, Elmoubarki R, Farnane M et al (2018) Photocatalytic degradation of caffeine as a model pharmaceutical pollutant on Mg doped ZnO-Al2O3 heterostructure. Environ Nanotechnology, Monit Manag 10:63–72. https://doi.org/10.1016/j.enmm.2018.02.002
El-Mched F, Olama Z, Holail H (2013) Optimization of the environmental and physiological factors affecting microbial caffeine degradation and its application in caffeinated products. Basic Res J Microbiol 1:17–27
Erukainure OL, Oyebode OA, Sokhela MK et al (2017) Caffeine – rich infusion from Cola nitida (kola nut) inhibits major carbohydrate catabolic enzymes; abates redox imbalance; and modulates oxidative dysregulated metabolic pathways and metabolites in Fe2+-induced hepatic toxicity. Biomed Pharmacother 96:1065–1074. https://doi.org/10.1016/j.biopha.2017.11.120
European Food Safety Authority (2014) Outcome of a public consultation on the draft scientific opinion of the EFSA panel on dietetic products, nutrition and allergies (NDA) on the essential composition of infant and follow-on formulae
Fair PA, Lee HB, Adams J et al (2009) Occurrence of triclosan in plasma of wild Atlantic bottlenose dolphins (Tursiops truncatus) and in their environment. Environ Pollut 157:2248–2254. https://doi.org/10.1016/j.envpol.2009.04.002
Fan L, Pandey A, Mohan R, Soccol CR (2000) Comparison of coffee industry residues for production of Pleurotus ostreatus in solid state fermentation. Acta Biotechnol 20(1):41–52
Fitt E, Pell D, Cole D (2013) Assessing caffeine intake in the United Kingdom diet. Food Chem 140:421–426. https://doi.org/10.1016/j.foodchem.2012.07.092
Frary CD, Johnson RK, Wang MQ (2005) Food sources and intakes of caffeine in the diets of persons in the United States. J Am Diet Assoc 105:110–113. https://doi.org/10.1016/j.jada.2004.10.027
Fredholm BB, Yang J, Wang Y (2017) Low, but not high, dose caffeine is a readily available probe for adenosine actions. Mol Asp Med 55:20–25. https://doi.org/10.1016/j.mam.2016.11.011
Fulgoni VL, Keast DR, Lieberman HR (2015) Trends in intake and sources of caffeine in the diets of US adults: 2001-2010. Am J Clin Nutr 101:1081–1087. https://doi.org/10.3945/ajcn.113.080077
Gao ZQ, Zhao DY, Xu L et al (2016) Paraburkholderia caffeinitolerans sp. nov., a caffeine degrading species isolated from a tea plantation soil sample. Antonie van Leeuwenhoek. Int J Gen Mol Microbiol 109:1475–1482. https://doi.org/10.1007/s10482-016-0749-7
Gao Q, Blum KM, Gago-Ferrero P et al (2019) Impact of on-site wastewater infiltration systems on organic contaminants in groundwater and recipient waters. Sci Total Environ 651:1670–1679. https://doi.org/10.1016/j.scitotenv.2018.10.016
Gardinali PR, Zhao X (2002) Trace determination of caffeine in surface water samples by liquid chromatography - atmospheric pressure chemical ionization - mass spectrometry (LC-APCI-MS). Environ Int 28:521–528. https://doi.org/10.1016/S0160-4120(02)00080-6
Garrido E, Camacho-Muñoz D, Martín J et al (2016) Monitoring of emerging pollutants in Guadiamar River basin (South of Spain): analytical method, spatial distribution and environmental risk assessment. Environ Sci Pollut Res 23:25127–25144. https://doi.org/10.1007/s11356-016-7759-x
Gelsleichter J, Szabo NJ (2013) Uptake of human pharmaceuticals in bull sharks (Carcharhinus leucas) inhabiting a wastewater-impacted river. Sci Total Environ 456–457:196–201. https://doi.org/10.1016/j.scitotenv.2013.03.078
Gera M, Kalra S, Gupta P (2016) Caffeine intake among adolescents in Delhi. Indian J Community Med 41:151. https://doi.org/10.4103/0970-0218.173501
Giovanini de Oliveira Sartori A, Vieira da Silva M (2016) Caffeine in Brazil: intake, socioeconomic and demographic determinants, and major dietary sources. Nutrire 41:11. https://doi.org/10.1186/s41110-016-0014-x
Glaze WH, Kang JW, Chapin DH, et al (1987) The Chemistry of Water Treatment Processes Involving Ozone, Hydrogen Peroxide and Ultraviolet Radiation. Ozone Sci Eng 9:335–352. https://doi.org/10.1080/01919518708552148
Glück M, Lingens F (1988) Heteroxanthinedemethylase, a new enzyme in the degradation of caffeine by Pseudomonas putida. Appl Microbiol Biotechnol 28:59–62. https://doi.org/10.1007/BF00250499
Gokulakrishnan S, Chandraraj K, Gummadi SN (2005) Microbial and enzymatic methods for the removal of caffeine. Enzym Microb Technol 37:225–232. https://doi.org/10.1016/j.enzmictec.2005.03.004
Gokulakrishnan S, Chandraraj K, Gummadi SN (2007) A preliminary study of caffeine degradation by Pseudomonas sp. GSC 1182. Int J Food Microbiol 113:346–350. https://doi.org/10.1016/j.ijfoodmicro.2006.07.005
Gonzalez CR, Gonzalez B, Matzkin ME et al (2015) Psychostimulant-induced testicular toxicity in mice: evidence of cocaine and caffeine effects on the local dopaminergic system. PLoS One:10. https://doi.org/10.1371/journal.pone.0142713
Gonzalez-Rey M, Tapie N, Le Menach K et al (2015) Occurrence of pharmaceutical compounds and pesticides in aquatic systems. Mar Pollut Bull 96:384–400. https://doi.org/10.1016/j.marpolbul.2015.04.029
Gros M, Blum KM, Jernstedt H et al (2017) Screening and prioritization of micropollutants in wastewaters from on-site sewage treatment facilities. J Hazard Mater 328:37–45. https://doi.org/10.1016/j.jhazmat.2016.12.055
Grosso G, Micek A, Castellano S et al (2016) Coffee, tea, caffeine and risk of depression: a systematic review and dose-response meta-analysis of observational studies. Mol Nutr Food Res 60:223–234. https://doi.org/10.1002/mnfr.201500620
Gummadi SN, Ganesh KB, Santhosh D (2009) Enhanced degradation of caffeine by immobilized cells of Pseudomonas sp. in agar-agar matrix using statistical approach. Biochem Eng J 44:136–141. https://doi.org/10.1016/j.bej.2008.11.010
Gutiérrez-Sánchez G, Roussos S, Augur C (2013) Effect of caffeine concentration on biomass production, caffeine degradation, and morphology of Aspergillus tamarii. Folia Microbiol (Praha) 58:195–200. https://doi.org/10.1007/s12223-012-0197-3
Hakil M, Denis S, Viniegra-González G, Augur C (1998) Degradation and product analysis of caffeine and related dimethylxanthines by filamentous fungi. Enzym Microb Technol 22:355–359. https://doi.org/10.1016/S0141-0229(97)00205-6
Hazelton PD, Du B, Haddad SP et al (2014) Chronic fluoxetine exposure alters movement and burrowing in adult freshwater mussels. Aquat Toxicol 151:27–35. https://doi.org/10.1016/j.aquatox.2013.12.019
Heckman MA, Weil J, de Mejia EG (2010) Caffeine (1, 3, 7-trimethylxanthine) in foods: A comprehensive review on consumption, functionality, safety, and regulatory matters. J Food Sci 75:77–87. https://doi.org/10.1111/j.1750-3841.2010.01561.x
Holbrook SJ, Schmitt RJ, Messmer V et al (2015) Reef fishes in biodiversity hotspots are at greatest risk from loss of coral species. PLoS One 10:1–12. https://doi.org/10.1371/journal.pone.0124054
Huang DL, Wang RZ, Liu YG et al (2014) Application of molecularly imprinted polymers in wastewater treatment: a review. Environ Sci Pollut Res 22:963–977. https://doi.org/10.1007/s11356-014-3599-8
Huerta-Fontela M, Galceran MT, Ventura F (2008) Stimulatory drugs of abuse in surface waters and their removal in a conventional drinking water treatment plant. Environ Sci Technol 42:6809–6816. https://doi.org/10.1021/es800768h
Ibrahim S, Shukor MY, Syed MA et al (2014) Bacterial degradation of caffeine: a review. Asian J Plant Biol 2:24–33
International Agency for Research on Cancer (IARC) WHO (WHO) (1991) IARC monographs on the evaluation of carcinogenic risks to humans. WHO 51:523. https://doi.org/10.1097/01.cej.0000243853.12728.76
Iori V, Pietrini F, Zacchini M (2012) Assessment of ibuprofen tolerance and removal capability in Populus nigra L. by in vitro culture. J Hazard Mater 229–230:217–223. https://doi.org/10.1016/j.jhazmat.2012.05.097
Iori V, Zacchini M, Pietrini F (2013) Growth, physiological response and phytoremoval capability of two willow clones exposed to ibuprofen under hydroponic culture. J Hazard Mater 262:796–804. https://doi.org/10.1016/j.jhazmat.2013.09.017
Jabbar SB, Hanly MG (2013) Fatal caffeine overdose: a case report and review of literature. Am J Forensic Med Pathol 34:321–324. https://doi.org/10.1097/PAF.0000000000000058
Kardani J, IR (2015) Understanding caffeine’s role in attenuating toxicity of α-synuclein aggregates: implications for risk of Parkinson’s disease. ACS Chem Neurosci 16:1613–1625. https://doi.org/10.1021/acschemneuro.5b00158
Kelly A, Becker W, Helsing E (1991) Food balance sheets, Rome. Available at: https://www.ncbi.nlm.nih.gov/pubmed/1750979
Klamerth N, Miranda N, Malato S et al (2009) Degradation of emerging contaminants at low concentrations in MWTPs effluents with mild solar photo-Fenton and TiO2. Catal Today 144:124–130. https://doi.org/10.1016/j.cattod.2009.01.024
Knee KL, Gossett R, Boehm AB, Paytan A (2010) Caffeine and agricultural pesticide concentrations in surface water and groundwater on the north shore of Kauai (Hawaii, USA). Mar Pollut Bull 60:1376–1382. https://doi.org/10.1016/j.marpolbul.2010.04.019
Lachenmeier DW, Wegert K, Kuballa T et al (2013) Caffeine intake from beverages in German children, adolescents, and adults. J Caffeine Res 3:47–53. https://doi.org/10.1089/jcr.2013.0008
Lai WWP, Lin YC, Wang YH et al (2018) Occurrence of emerging contaminants in aquaculture waters: cross-contamination between aquaculture systems and surrounding waters. Water Air Soil Pollut 229. https://doi.org/10.1007/s11270-018-3901-3
Lam MW, Young CJ, Brain RA, Johnson DJ, Hanson MA, Wilson CJ,et al. (2004) Aquatic persistence of eight pharmaceuticals in a microcosm study. Environ Toxicol Chem 23(6):1431–1440. https://doi.org/10.1897/03-421
Lee W, Wang YC (2015) Assessing developmental toxicity of caffeine and sweeteners in medaka (Oryzias latipes). Springerplus 4. https://doi.org/10.1186/s40064-015-1284-0
Lempart A, Kudlek E, Dudziak M (2018) Concentration levels of selected pharmaceuticals in swimming pool water. Desalin Water Treat 117:353–361. https://doi.org/10.5004/dwt.2018.22552
Li Y, Zhu G, Ng WJ, Tan SK (2014) A review on removing pharmaceutical contaminants from wastewater by constructed wetlands: design, performance and mechanism. Sci Total Environ 468–469:908–932. https://doi.org/10.1016/j.scitotenv.2013.09.018
Li J, Zhou Q, Campos LC (2017) Removal of selected emerging PPCP compounds using greater duckweed (Spirodela polyrhiza) based lab-scale free water constructed wetland. Water Res 126:252–261. https://doi.org/10.1016/j.watres.2017.09.002
Lim HS, Hwang JY, Choi JC, Kim M (2015) Assessment of caffeine intake in the Korean population. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess 32:1786–1798. https://doi.org/10.1080/19440049.2015.1077396
Lopez B, Ollivier P, Togola A et al (2015) Screening of French groundwater for regulated and emerging contaminants. Sci Total Environ 518–519:562–573. https://doi.org/10.1016/j.scitotenv.2015.01.110
Luo Z, Tu Y, Li H et al (2019) Endocrine-disrupting compounds in the Xiangjiang River of China: spatio-temporal distribution, source apportionment, and risk assessment. Ecotoxicol Environ Saf 167:476–484. https://doi.org/10.1016/j.ecoenv.2018.10.053
Madyastha KM, Sridhar GR (1998) A novel pathway for the metabolism of caffeine by a mixed culture consortium. Biochem Biophys Res Commun 249:178–181. https://doi.org/10.1006/bbrc.1998.9102
Mar da Costa NY, Boaventura GR, Mulholland DS et al (2016) Biogeochemical mechanisms controlling trophic state and micropollutant concentrations in a tropical artificial lake. Environ Earth Sci 75. https://doi.org/10.1007/s12665-016-5629-y
Marques RRN, Sampaio MJ, Carrapiço PM et al (2013) Photocatalytic degradation of caffeine: developing solutions for emerging pollutants. Catal Today 209:108–115. https://doi.org/10.1016/j.cattod.2012.10.008
Martinez-Haya R, Gomis J, Arques A et al (2018) Direct detection of the triphenylpyrylium-derived short-lived intermediates in the photocatalyzed degradation of acetaminophen, acetamiprid, caffeine and carbamazepine. J Hazard Mater 356:91–97. https://doi.org/10.1016/j.jhazmat.2018.05.023
Martínez-Hernández V, Meffe R, Herrera Lσpez S, de Bustamante I (2016) The role of sorption and biodegradation in the removal of acetaminophen, carbamazepine, caffeine, naproxen and sulfamethoxazole during soil contact: a kinetics study. Sci Total Environ 559:232–241. https://doi.org/10.1016/j.scitotenv.2016.03.131
Martínez-Hernández V, Leal M, Meffe R et al (2018) Removal of emerging organic contaminants in a poplar vegetation filter. J Hazard Mater 342:482–491. https://doi.org/10.1016/j.jhazmat.2017.08.035
Matongo S, Birungi G, Moodley B, Ndungu P (2015a) Pharmaceutical residues in water and sediment of Msunduzi River, KwaZulu-Natal, South Africa. Chemosphere 134:133–140. https://doi.org/10.1016/j.chemosphere.2015.03.093
Matongo S, Birungi G, Moodley B, Ndungu P (2015b) Occurrence of selected pharmaceuticals in water and sediment of Umgeni River, KwaZulu-Natal, South Africa. Environ Sci Pollut Res 22:10298–10308. https://doi.org/10.1007/s11356-015-4217-0
Mazzafera P (2002) Degradation of caffeine by microorganisms and potential use of decaffeinated coffee husk and pulp in animal feeding. Sci Agric 59:815–821. https://doi.org/10.1590/S0103-90162002000400030
Mazzafera P (2007) Catabolism of caffeine in plants and microorganisms. Front Biosci 9:1348. https://doi.org/10.2741/1339
Mazzafera E, O’Olsson GS (1996) Degradation of caffeine and related methylxanthines by Serratia marcescens isolated from soil under coffee cultivation. Microb Ecol 31:199–207
Mceachran AD, Shea D, Bodnar W, Nichols EG (2017) in Forests land-applied with municipal wastewater. Environ Toxicol 35:898–905. https://doi.org/10.1002/etc.3216.Data
Melvin SD, Buck DR, Fabbro LD (2016) Diurnal activity patterns as a sensitive behavioural outcome in fish: effect of short-term exposure to treated sewage and a sub-lethal PPCP mixture. J Appl Toxicol 36:1173–1182. https://doi.org/10.1002/jat.3284
Mendoza A, Zonja B, Mastroianni N et al (2016) Drugs of abuse, cytostatic drugs and iodinated contrast media in tap water from the Madrid region (central Spain): a case study to analyse their occurrence and human health risk characterization. Environ Int 86:107–118. https://doi.org/10.1016/j.envint.2015.11.001
Milić N, Milanović M, Radonić J et al (2018) The occurrence of selected xenobiotics in the Danube river via LC-MS/MS. Environ Sci Pollut Res 25:11074–11083. https://doi.org/10.1007/s11356-018-1401-z
Miranda-García N, Suárez S, Sánchez B et al (2011) Photocatalytic degradation of emerging contaminants in municipal wastewater treatment plant effluents using immobilized TiO2 in a solar pilot plant. Appl Catal B Environ 103:294–301. https://doi.org/10.3233/978-1-61499-798-6-38
Mirzaei A, Chen Z, Haghighat F, Yerushalmi L (2017) Removal of pharmaceuticals from water by homo/heterogonous Fenton-type processes–a review. Chemosphere 174:665–688. https://doi.org/10.1016/j.chemosphere.2017.02.019
Mitchell DC, Knight CA, Hockenberry J et al (2014) Beverage caffeine intakes in the U.S. Food Chem Toxicol 63:136–142. https://doi.org/10.1016/j.fct.2013.10.042
Munter R (2001) Advanced Oxidation Processes—Current Status and Prospects. Proc Estonian Acad Sci Chem 50(2):59–80
Mustard JA, Dews L, Brugato A et al (2012) Consumption of an acute dose of caffeine reduces acquisition but not memory in the honey bee. Behav Brain Res 232:217–224. https://doi.org/10.1016/j.bbr.2012.04.014
Mutiyar PK, Gupta SK, Mittal AK (2018) Fate of pharmaceutical active compounds (PhACs) from River Yamuna, India: an ecotoxicological risk assessment approach. Ecotoxicol Environ Saf 150:297–304. https://doi.org/10.1016/j.ecoenv.2017.12.041
Nakada N, Hanamoto S, Juergens MD, Johnson AC, Bowes MJ, Tanaka H (2017) Assessing the population equivalent and performance of wastewater treatment through the ratios of pharmaceuticals and personal care products present in a river basin: application to the River Thames basin, UK. Total Environ 575:1100–1108. https://doi.org/10.1016/j.scitotenv.2016.09.180
Nakaoka S, Kawasaki Y, Inomata S et al (2017) Caffeine toxicity in a preterm neonate. Pediatr Neonatol 58:380–381. https://doi.org/10.1016/j.pedneo.2016.08.001
Nanjundaiah S, Bhatt P, Rastogi NK, Thakur MS (2016) Response surface optimization for decaffeination and theophylline production by Fusarium solani. Appl Biochem Biotechnol 178:58–75. https://doi.org/10.1007/s12010-015-1858-x
Nawrot P, Jordan S, Eastwood J et al (2003) Effects of caffeine on human health. Food Addit Contam 20:1–30. https://doi.org/10.1080/0265203021000007840
Nayak V, Pai PV, Pai A et al (2013) A comparative study of caffeine degradation by four different fungi. Bioremediat J 17:79–85. https://doi.org/10.1080/10889868.2012.751960
Nödler K, Voutsa D, Licha T (2014) Polar organic micropollutants in the coastal environment of different marine systems. Mar Pollut Bull 85:50–59. https://doi.org/10.1016/j.marpolbul.2014.06.024
Nunes B (2015) Pharmaceutical drugs and other substances with pharmacological activity in the environment: a threat to biodiversity? Conserv Sci 2:12–16. https://doi.org/10.3126/cs.v2i1.13764
Owen SF, Huggett DB, Hutchinson TH et al (2009) Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry. Aquat Toxicol 93:217–224. https://doi.org/10.1016/j.aquatox.2009.05.009
Palma D, Prevot AB, Brigante M et al (2018) New insights on the photodegradation of caffeine in the presence of bio-based substances-magnetic iron oxide hybrid nanomaterials. Materials (Basel) 11:1–17. https://doi.org/10.3390/ma11071084
Papageorgiou M, Kosma C, Lambropoulou D (2016) Seasonal occurrence, removal, mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece. Sci Total Environ 543:547–569. https://doi.org/10.1016/j.scitotenv.2015.11.047
Park N, Choi Y, Kim D et al (2018) Prioritization of highly exposable pharmaceuticals via a suspect/non-target screening approach: a case study for Yeongsan River, Korea. Sci Total Environ 639:570–579. https://doi.org/10.1016/j.scitotenv.2018.05.081
Peeler KA, Opsahl SP, Chanton JP (2006) Tracking anthropogenic inputs using caffeine, indicator bacteria, and nutrients in rural freshwater and urban marine systems. Environ Sci Technol 40:7616–7622. https://doi.org/10.1021/es061213c
Pendleton M, Brown S, Thomas CM, Odle B (2013) Potential toxicity of caffeine when used as a dietary supplement for weight loss. J Diet Suppl 10:1–5. https://doi.org/10.3109/19390211.2012.758215
Pérez MR, Rossi AS, Bacchetta C et al (2018) In situ evaluation of the toxicological impact of a wastewater effluent on the fish Prochilodus lineatus: biochemical and histological assessment. Ecol Indic 84:345–353. https://doi.org/10.1016/j.ecolind.2017.09.004
Pi N, Ng JZ, Kelly BC (2017) Bioaccumulation of pharmaceutically active compounds and endocrine disrupting chemicals in aquatic macrophytes: results of hydroponic experiments with Echinodorus horemanii and Eichhornia crassipes. Sci Total Environ 601–602:812–820. https://doi.org/10.1016/j.scitotenv.2017.05.137
Pierattini EC, Francini A, Raffaelli A, Sebastiani L (2016) Degradation of exogenous caffeine by Populus alba and its effects on endogenous caffeine metabolism. Environ Sci Pollut Res 23:7298–7307. https://doi.org/10.1007/s11356-015-5935-z
Pitaksalee R, Sanvarinda Y, Sinchai T et al (2015) Autophagy inhibition by caffeine increases toxicity of methamphetamine in SH-SY5Y Neuroblastoma Cell Line. Neurotox Res 27:421–429. https://doi.org/10.1007/s12640-014-9513-9
Quinn B, Gagné F, Blaise C (2008) An investigation into the acute and chronic toxicity of eleven pharmaceuticals (and their solvents) found in wastewater effluent on the cnidarian, Hydra attenuata. Sci Total Environ 389:306–314. https://doi.org/10.1016/j.scitotenv.2007.08.038
Rah YC, Yoo MH, Choi J et al (2017) In vivo assessment of hair cell damage and developmental toxicity caused by gestational caffeine exposure using zebrafish (Danio rerio) models. Neurotoxicol Teratol 64:1–7. https://doi.org/10.1016/j.ntt.2017.08.003
Rahangdale D, Kumar A (2018a) Chitosan as a substrate for simultaneous surface imprinting of salicylic acid and cadmium, Carbohydrate. Polymers 202:334–344
Rahangdale D, Kumar A (2018b) Water compatible functionalized chitosan-based 4-HBA mimic imprinted polymer as a potential sorbent for salicylic acid. Sep Sci Technol. https://doi.org/10.1080/01496395.2018.1546739
Rahangdale D, Kumar A (2018c) Derivatized chitosan: fundamentals to applications. Biopolymer grafting, Elsevier: 251–284
Rahangdale D, Archana G, Dhodapkar R, Kumar A (2017) Chitosan-based biosorbents: modifications and application for sequestration of PPCPs and metals for water remediation. Handb Compos from Renew Mater 1–8:1–25. https://doi.org/10.1002/9781119441632.ch63
Rahangdale D, Kumar A, Archana G, Dhodapkar RS (2018) Ion cum molecularly dual imprinted polymer for simultaneous removal of cadmium and salicylic acid. J Mol Recognit:31. https://doi.org/10.1002/jmr.2630
Rivas J, Gimeno O, Borralho T, Sagasti J (2011) UV-C and UV-C/peroxide elimination of selected pharmaceuticals in secondary effluents. Desalination 279:115–120. https://doi.org/10.1016/j.desal.2011.05.066
Rodriguez del Rey Z, Granek EF, Sylvester S (2012) Occurrence and concentration of caffeine in Oregon coastal waters. Mar Pollut Bull 64:1417–1424. https://doi.org/10.1016/j.marpolbul.2012.04.015
Rodriguez RS, Haugen R, Rueber A, Huang CC (2014) Reversible neuronal and muscular toxicity of caffeine in developing vertebrates. Comp Biochem Physiol Part - C Toxicol Pharmacol 163:47–54. https://doi.org/10.1016/j.cbpc.2014.03.004
Roussos S, Aquiahuatl M de los A, Trejo-hern MR, et al. (1995) Biotechnological management of coffee pulp- isolation, screening, characterization, selection of caffeine-degrading fungi and natural microflora present in coffee pulp and husk. Appl Microbiol Biotechnol 42:756–762
Rudolph E, Färbinger A, König J (2012) Determination of the caffeine contents of various food items within the Austrian market and validation of a caffeine assessment tool (CAT). Food Addit Contam - Part A Chem Anal Control Expo Risk Assess 29:1849–1860. https://doi.org/10.1080/19440049.2012.719642
Rudolph E, Faerbinger A, Koenig J (2014) Caffeine intake from all sources in adolescents and young adults in Austria. Eur J Clin Nutr 68:793–798. https://doi.org/10.1038/ejcn.2014.50
Schwimmer S, Kurtzman RH and EH (1971) Caffeine metabolism by Penicillium roqueforti. Arch Biochem Biophys 147:109–113
Scott PD, Bartkow M, Blockwell SJ et al (2014) A national survey of trace organic contaminants in Australian Rivers. J Environ Qual 43:1702. https://doi.org/10.2134/jeq2014.01.0012
Sharma BM, Bečanová J, Scheringer M et al (2019) Health and ecological risk assessment of emerging contaminants (pharmaceuticals, personal care products, and artificial sweeteners) in surface and groundwater (drinking water) in the Ganges River Basin, India. Sci Total Environ 646:1459–1467. https://doi.org/10.1016/j.scitotenv.2018.07.235
Si A, Zhang SW, Maleszka R (2005) Effects of caffeine on olfactory and visual learning in the honey bee (Apis mellifera). Pharmacol Biochem Behav 82:664–672. https://doi.org/10.1016/j.pbb.2005.11.009
Siegener R, Chen RF (2002) Caffeine in Boston harbor seawater. Mar Pollut Bull 44:383–387. https://doi.org/10.1016/S0025-326X(00)00176-4
Singh SP, Azua A, Chaudhary A et al (2010) Occurrence and distribution of steroids, hormones and selected pharmaceuticals in South Florida coastal environments. Ecotoxicology 19:338–350. https://doi.org/10.1007/s10646-009-0416-0
Song Y, Chai T, Yin Z et al (2018) Stereoselective effects of ibuprofen in adult zebrafish (Danio rerio) using UPLC-TOF/MS-based metabolomics. Environ Pollut 241:730–739. https://doi.org/10.1016/j.envpol.2018.06.009
Souza FS, Féris LA (2015) Degradation of caffeine by advanced oxidative processes: O3and o3/UV. Ozone Sci Eng 37:379–384. https://doi.org/10.1080/01919512.2015.1016572
Sposito JCV, Montagner CC, Casado M et al (2018) Emerging contaminants in Brazilian rivers: occurrence and effects on gene expression in zebrafish (Danio rerio) embryos. Chemosphere 209:696–704. https://doi.org/10.1016/j.chemosphere.2018.06.046
Stavric B, Klassen R, Watkinson B et al (1988) Variability in caffeine consumption from coffee and tea: possible significance for epidemiological studies. Food Chem Toxicol 26:111–118. https://doi.org/10.1016/0278-6915(88)90107-X
Subedi B, Codru N, Dziewulski DM et al (2014) A pilot study on the assessment of trace organic contaminants including pharmaceuticals and personal care products from on-site wastewater treatment systems along Skaneateles Lake in New York State, USA. Water Res 72:28–39. https://doi.org/10.1016/j.watres.2014.10.049
Summers RM, Mohanty SK, Gopishetty S, Subramanian M (2015) Genetic characterization of caffeine degradation by bacteria and its potential applications. Microb Biotechnol 8:369–378. https://doi.org/10.1111/1751-7915.12262
Sun Q, Li M, Ma C et al (2016a) Seasonal and spatial variations of PPCP occurrence, removal and mass loading in three wastewater treatment plants located in different urbanization areas in Xiamen, China. Environ Pollut 208:371–381. https://doi.org/10.1016/j.envpol.2015.10.003
Sun Q, Li Y, Li M et al (2016b) PPCPs in Jiulong River estuary (China): Spatiotemporal distributions, fate, and their use as chemical markers of wastewater. Chemosphere 150:596–604. https://doi.org/10.1016/j.chemosphere.2016.02.036
Sun C, Dudley S, Trumble J, Gan J (2018) Pharmaceutical and personal care products-induced stress symptoms and detoxification mechanisms in cucumber plants. Environ Pollut 234:39–47. https://doi.org/10.1016/j.envpol.2017.11.041
Tan C, Gao N, Zhou S et al (2014) Kinetic study of acetaminophen degradation by UV-based advanced oxidation processes. Chem Eng J 253:229–236. https://doi.org/10.1016/j.cej.2014.05.013
Teo TLL, Coleman HM, Khan SJ (2016) Occurrence and daily variability of pharmaceuticals and personal care products in swimming pools. Environ Sci Pollut Res 23:6972–6981. https://doi.org/10.1007/s11356-015-5967-4
Tian D-T, Zhou Y-C, Xiong L, Lu F-T (2017) Synthesis and properties of caffeine molecularly imprinted polymers based on Konjac glucomannan. Adv Polym Technol 36:68–76. https://doi.org/10.1002/adv.21575
Tiwari KK, Chu C, Couroucli X et al (2014) Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro. Biochem Biophys Res Commun 450:1345–1350. https://doi.org/10.1016/j.bbrc.2014.06.132
Tong AJ, Ghoshdastidar SF, Z A (2015) The presence of the top prescribed pharmaceuticals in treated sewage effluents and receiving waters in Southwest Nova Scotia, Canada. Environ Sci Pollut Res 22:689–700. https://doi.org/10.1007/s11356-014-3400-z
Trovó AG, Silva TFS, Gomes O et al (2013) Degradation of caffeine by photo-Fenton process: optimization of treatment conditions using experimental design. Chemosphere 90:170–175. https://doi.org/10.1016/j.chemosphere.2012.06.022
Verster JC, Koenig J (2018) Caffeine intake and its sources: a review of national representative studies. Crit Rev Food Sci Nutr 58:1250–1259. https://doi.org/10.1080/10408398.2016.1247252
Vogels G, van der Drift C (1976) Degradation of purines and pyrimidines by microorganisms. Bacteriol Rev 40:963
Weigel S, Kuhlmann J, Hühnerfuss H (2002) Drugs and personal care products as ubiquitous pollutants: occurrence and distribution of clofibric acid, caffeine and DEET in the North Sea. Sci Total Environ 295:131–141. https://doi.org/10.1016/S0048-9697(02)00064-5
Weissinger RH, Blackwell BR, Keteles K et al (2018) Bioactive contaminants of emerging concern in National Park waters of the northern Colorado Plateau, USA. Sci Total Environ 636:910–918. https://doi.org/10.1016/j.scitotenv.2018.04.332
Williams M, Kookana RS, Mehta A et al (2019) Emerging contaminants in a river receiving untreated wastewater from an Indian urban centre. Sci Total Environ 647:1256–1265. https://doi.org/10.1016/j.scitotenv.2018.08.084
Woolfolk CA (1975) Metabolism of N methylpurines by a Pseudomonas putida strain isolated by enrichment on caffeine as the sole source of carbon and nitrogen. J Bacteriol 123:1088–1106
Xu C, Chen L, You L et al (2018) Occurrence, impact variables and potential risk of PPCPs and pesticides in a drinking water reservoir and related drinking water treatment plants in the Yangtze Estuary. Environ Sci Process Impacts 20:1030–1045. https://doi.org/10.1039/c8em00029h
Yamamoto T, Yoshizawa K, Kubo S et al (2015) Autopsy report for a caffeine intoxication case and review of the current literature. J Toxicol Pathol 28:33–36. https://doi.org/10.1293/tox.2014-0044
Yang DZ, Lei GMNS (2018) Investigation of pre- and postnatal developmental toxicity of caffeine in rats. Reston, Virginia
You L, Nguyen VT, Pal A et al (2015) Investigation of pharmaceuticals, personal care products and endocrine disrupting chemicals in a tropical urban catchment and the influence of environmental factors. Sci Total Environ 536:955–963. https://doi.org/10.1016/j.scitotenv.2015.06.041
Yu H, Cao W (2016) Assessment of pharmaceutical and personal care products (PPCPs) of Dalong Lake in Xuzhou by concentration monitoring and bio-effects monitoring process. Environ Toxicol Pharmacol 43:209–215. https://doi.org/10.1016/j.etap.2016.03.015
Zhang DQ, Hua T, Gersberg RM et al (2013) Fate of caffeine in mesocosms wetland planted with Scirpus validus. Chemosphere 90:1568–1572. https://doi.org/10.1016/j.chemosphere.2012.09.059
Zhang P, Zhou H, Li K et al (2017) Occurrence of pharmaceuticals and personal care products, and their associated environmental risks in a large shallow lake in north China. Environ Geochem Health 40:1525–1539. https://doi.org/10.1007/s10653-018-0069-0
Zhang P, Zhou H, Li K et al (2018) Occurrence of pharmaceuticals and personal care products, and their associated environmental risks in Guanting Reservoir and its upstream rivers in north China. RSC Adv 8:4703–4712. https://doi.org/10.1039/C7RA12945A
Zhou B, Ma C, Wang H, Xia T (2018) Biodegradation of caffeine by whole cells of tea-derived fungi Aspergillus sydowii, Aspergillus niger and optimization for caffeine degradation. BMC Microbiol 18:1–10. https://doi.org/10.1186/s12866-018-1194-8
Zucconi S, Volpato C, Adinolfi F et al (2013) Gathering consumption data on specific consumer groups of energy drinks. EFSA Support Publ 10:1–190. https://doi.org/10.2903/sp.efsa.2013.EN-394
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Girish Korekar thank Dr. P.M.Padole, Director, VNIT, Nagpur, Dr. S.S. Umare, HoD, Department of Chemistry and Ms. G. Archana , Research Scholar for their constant support.
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Korekar, G., Kumar, A. & Ugale, C. Occurrence, fate, persistence and remediation of caffeine: a review. Environ Sci Pollut Res 27, 34715–34733 (2020). https://doi.org/10.1007/s11356-019-06998-8
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