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Evaluate the effect of cadmium on levels of zinc in scalp hair and blood samples of smoker and nonsmoker psoriatic patients at different stage

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Abstract

Psoriasis, a skin inflammatory disease, originates from dysregulated interactions of the immune system and environmental factors. In the present study, cadmium (Cd) and zinc (Zn) were analyzed in biological samples (blood and scalp hair) of smoker and nonsmoker males who have mild and severe psoriasis. The patients were evaluated according to criteria based on the standard clinical diagnosis and classified into mild and severe psoriasis groups using the Psoriasis Area Severity Index (PASI) score. Both elements were determined by atomic absorption spectrometry after matrix oxidation. In smoker psoriatic patients, the level of Cd in biological samples was significantly increased. The Zn was significantly decreased in smoker mild and severe psoriatic patients as related to nonsmokers’ referents and patients. The resulted data indicated that the levels of Zn in smoker referents were about 5.0% lower than nonsmoker’s referents. While the concentrations of Zn in blood samples of nonsmoker’s mild and severe psoriatic patients have 17.8 to 33.3% lower than nonsmoker’s referents. The results indicate that the level of Cd in blood samples of referent smokers has ≥ 25% than nonsmokers, whereas the psoriatic patients at different stages have two- to threefold higher Cd in both biological samples.

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Authors and Affiliations

  1. National Centre of Excellence in Analytical Chemistry (NCEAC), University of Sindh, Jamshoro, 76080, Pakistan

    Suraya Samejo, Hassan I. Afridi & Tasneem G. Kazi

  2. Department of Dermatology, Liaquat University of Medical and Health Sciences, Jamshoro, 76080, Pakistan

    Atif G. Kazi

Authors
  1. Suraya Samejo
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  2. Atif G. Kazi
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  3. Hassan I. Afridi
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  4. Tasneem G. Kazi
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Correspondence to Hassan I. Afridi.

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The approval for biological sampling was got from the Ethical Committee of advanced study and research of the University of Sindh, Jamshoro. The verbal/written consent was attained from the controls/patients before sample collection.

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Responsible editor: Philippe Garrigues

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Samejo, S., Kazi, A.G., Afridi, H.I. et al. Evaluate the effect of cadmium on levels of zinc in scalp hair and blood samples of smoker and nonsmoker psoriatic patients at different stage. Environ Sci Pollut Res 26, 31763–31769 (2019). https://doi.org/10.1007/s11356-019-06226-3

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  • DOI: https://doi.org/10.1007/s11356-019-06226-3

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