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Assessment of the structural reorganization of liver and biochemical parameters of blood serum after introduction of zinc nanoparticles and its oxides

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Abstract

The demand for nanoparticles of metals and their oxides in medicine and biology is indisputable. To ensure the safe use of the unique capabilities of nanostructures, in particular, essential metals and their oxides, and to further search for ways leveling side effects of toxic effects in biomedical applications, a multifaceted approach to the study of their properties is needed, primarily affecting the effects on the organism level. In this connection, the purpose of the present research was to study the effect of zinc nanoparticles (ZnNPs) and zinc oxide nanoparticles (ZnONPs) on structural reorganization of the liver and morpho-biochemical parameters of rat blood. The test substances exhibit a hepatotoxic effect upon their single intraperitoneal administration to rats. In the experiment, increased activity of gamma glutamyltransferase (GGT) and lactate dehydrogenase (LDH), increased expression of caspase-3, the presence of signs of oxidative stress, inflammation, and capillary-trophic insufficiency, and induction of tumor necrosis factor (TNF-α), and colony stimulating factor 2 (granulocyte-macrophage) (GM-CSF) were registered in the experiment. The level of interferon-γ in the experimental groups tended to decrease in comparison with the control group. The observed effects progressed in time, most noticeably manifested in the case of ZnONPs. Comparing the dosages, ZnNPs are less toxic than ZnONPs.

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Acknowledgements

Research was done with financial support of the Russian Science Foundation # 14-16-00060-P.

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  1. Federal Research Centre of Biological Systems and Agro-Technologies of the Russian Academy of Sciences, Orenburg State University, Orenburg, Russia

    Elena Sizova, Sergey Miroshnikov & Xenia Nechitailo

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  1. Elena Sizova
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Correspondence to Elena Sizova.

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Sizova, E., Miroshnikov, S. & Nechitailo, X. Assessment of the structural reorganization of liver and biochemical parameters of blood serum after introduction of zinc nanoparticles and its oxides. Environ Sci Pollut Res 26, 17110–17120 (2019). https://doi.org/10.1007/s11356-019-05128-8

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