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LncRNA LINC00152 promoted glioblastoma progression through targeting the miR-107 expression

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10 April 2024 Editor's Note: Readers are alerted that the concerns have been raised with this article. Editorial action will be taken as appropriate once this matter is resolved and all parties have been given an opportunity to respond in full.

Abstract

Long non-coding RNAs (lncRNAs) LINC00152 plays important roles in the progression of some tumors. However, the role of LINC00152 in human l glioblastoma is still unknown. In this study, we indicated that LINC00152 expression level was upregulated in glioblastoma tissues and cell lines. Overexpression of LINC00152 promoted the U87 and LN229 cell proliferation and invasion. Moreover, overexpression of LINC00152 suppressed the E-cadherin expression, where ectopic expression of LINC00152 promoted the N-cadherin, Vimentin, and Snail expression. These results suggested that LINC00152 enhanced epithelial-to-mesenchymal transition (EMT) program in the glioblastoma cell. Overexpression of LINC00152 suppressed the miR-107 expression in the U87 cell and enhanced the HMGA2 expression, which is a direct target gene of miR-107. In addition, we showed that the miR-107 expression was downregulated in the glioblastoma tissues and cell lines. Interesting, the expression of LINC00152 was negatively related with miR-107 expression in the glioblastoma tissues. Furthermore, LINC00152 promoted the glioblastoma cell proliferation and invasion through inhibiting miR-107 expression. These data suggested that LINC00152 acted as oncogene roles in the glioblastoma cell partly through targeting the miR-107 expression.

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  • 10 April 2024

    Editor's Note: Readers are alerted that the concerns have been raised with this article. Editorial action will be taken as appropriate once this matter is resolved and all parties have been given an opportunity to respond in full.

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Authors and Affiliations

  1. Department of Neurosurgery, Affiliated Chinese Medicine Hospital of Xinjiang Medical University, Urumqi, 830000, China

    Xinzhi Liu, Yimamu· Yidayitula, Heng Zhao, Yi Luo, Xiaoqiang Ma & Minhua Xu

  2. Department of cerebral surgery, Affiliated Chinese Medicine Hospital of Xinjiang Medical University, Urumqi, 830000, China

    Minhua Xu

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  1. Xinzhi Liu
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  2. Yimamu· Yidayitula
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  3. Heng Zhao
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  4. Yi Luo
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  5. Xiaoqiang Ma
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  6. Minhua Xu
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Correspondence to Minhua Xu.

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Responsible editor: Philippe Garrigues

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Liu, X., Yidayitula, Y., Zhao, H. et al. LncRNA LINC00152 promoted glioblastoma progression through targeting the miR-107 expression. Environ Sci Pollut Res 25, 17674–17681 (2018). https://doi.org/10.1007/s11356-018-1784-x

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  • DOI: https://doi.org/10.1007/s11356-018-1784-x

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