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Nonribosomal peptides and polyketides of Burkholderia: new compounds potentially implicated in biocontrol and pharmaceuticals

  • Chemistry, Activity and Impact of Plant Biocontrol products
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Abstract

Bacteria belonging to the genus Burkholderia live in various ecological niches and present a significant role in the environments through the excretion of a wide variety of secondary metabolites including modular nonribosomal peptides (NRPs) and polyketides (PKs). These metabolites represent a widely distributed biomedically and biocontrol important class of natural products including antibiotics, siderophores, and anticancers as well as biopesticides that are considered as a novel source that can be used to defend ecological niche from competitors and to promote plant growth. The aim of this review is to present all NRPs produced or potentially produced by strains of Burkholderia, as NRPs represent a major source of active compounds implicated in biocontrol. The review is a compilation of results from a large screening we have performed on 48 complete sequenced genomes available in NCBI to identify NRPS gene clusters, and data found in the literature mainly because some interesting compounds are produced by strains not yet sequenced. In addition to NRPs, hybrids NRPs/PKs are also included. Specific features about biosynthetic gene clusters and structures of the modular enzymes responsible for the synthesis, the biological activities, and the potential uses in agriculture and pharmaceutical of NRPs and hybrids NRPs/PKs will also be discussed.

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Acknowledgements

This work was supported by the University of Lille 1, the INTERREG IVa program France-Wallonie-Vlaanderen (Phytobio project), the INTERREGVa program (SmartBioControle/BioScreen project), and the bioinformatics platform bilille.

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Authors and Affiliations

  1. University Lille, INRA, ISA, University Artois, University Littoral Côte d’Opale, EA 7394-ICV- Institut Charles Viollette, F-59000, Lille, France

    Qassim Esmaeel, Philippe Jacques & Valérie Leclère

  2. Laboratoire de Stress, Défenses et Reproduction des Plantes URVVC-EA 4707, UFR Sciences Exactes et Naturelles, University of Reims-Champagne-Ardenne, Reims, France

    Qassim Esmaeel

  3. University Lille, CNRS, Centrale Lille, UMR 9189- CRIStAL- Centre de Recherche en Informatique Signal et Automatique de Lille, F-59000, Lille, France

    Maude Pupin & Valérie Leclère

  4. Inria-Lille Nord Europe, Bonsai team, F-59655, Villeneuve d’Ascq Cedex, France

    Maude Pupin & Valérie Leclère

  5. TERRA Research Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech University of Liege, B-5030, Gembloux, Belgium

    Philippe Jacques

Authors
  1. Qassim Esmaeel
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  2. Maude Pupin
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  3. Philippe Jacques
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  4. Valérie Leclère
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Corresponding author

Correspondence to Valérie Leclère.

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The authors declare that they have no conflict of interest.

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Responsible editor: Gerald Thouand

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Esmaeel, Q., Pupin, M., Jacques, P. et al. Nonribosomal peptides and polyketides of Burkholderia: new compounds potentially implicated in biocontrol and pharmaceuticals. Environ Sci Pollut Res 25, 29794–29807 (2018). https://doi.org/10.1007/s11356-017-9166-3

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  • DOI: https://doi.org/10.1007/s11356-017-9166-3

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