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Exogenous phosphatidylcholine supplementation retrieve aluminum-induced toxicity in male albino rats

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Abstract

This study investigated the ameliorative potential of exogenous phosphatidylcholine (PC) against aluminum-induced toxicity in male albino rats. Four groups of rats were used for this study (N = 8): group I served as the control, group II (PC treated) received l-α-phosphatidylcholine (egg yolk-derived) 100 mg/kg bwt/day orally, group III (aluminum treated) received aluminum chloride 100 mg/kg bwt/day orally, and group VI (aluminum + PC treated) received similar oral dose of aluminum and PC (100 mg/kg bwt/day). Treatment was continued for 8 weeks. Results revealed that aluminum chloride treatment leading to a significant elevation in serum aspartate aminotransferase, serum alanine aminotransferase, urea, creatinine, malondialdehyde, serum cytokines (tumor necrosis factor-α, interleukin-6), and brain content of acetylcholine, as well as a significant reduction in serum-reduced glutathione, serum testosterone, and brain content of acetylcholinesterase. Moreover, aluminum administration caused significant histopathological alteration in liver, kidney, brain, testes, and epididymis. Co-treatment with exogenous PC resulted in significant improvement in intensity of histopathologic lesions, serum parameters, testosterone level, proinflammatory cytokines, and oxidative/antioxidative status. However, it does not affect the brain content of acetylcholine and acetylcholinesterase. Conclusively, treatment with exogenous PC can retrieve the adverse effect of aluminum toxicities through its antioxidative and anti-inflammatory properties.

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Acknowledgments

The author gratefully thanks Dr. Ayman E. Taha, Assistant Professor of Poultry Breeding and Production, Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Egypt, for performing the statistical analysis.

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  1. Department of Pathology, Faculty of Veterinary Medicine, Alexandria University, Edfina-Rasheed, Behira, Egypt

    Asmaa Fahmy Khafaga

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Khafaga, A.F. Exogenous phosphatidylcholine supplementation retrieve aluminum-induced toxicity in male albino rats. Environ Sci Pollut Res 24, 15589–15598 (2017). https://doi.org/10.1007/s11356-017-9151-x

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