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Serum Romo1 is significantly associated with disease severity in patients with obstructive sleep apnea syndrome

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

We aim to evaluate reactive oxygen species modulator 1 (Romo1) levels in obstructive sleep apnea syndrome (OSAS) and analyze its possible relationships to OSAS severity, reactive oxygen species (ROS), and C-reactive protein (CRP). Additionally, we also investigated the effects of nasal continuous positive airway pressure (nCPAP) on serum Romo1.

Methods

One hundred and five patients diagnosed with OSAS were classified into the OSAS group, and 41 subjects without OSAS were recruited for the control group. The OSAS group was further divided into mild, moderate, and severe OSAS subgroups. Fifteen patients with moderate and severe OSAS were treated with nCPAP. Serum levels of Romo1, ROS, and CRP were also measured.

Results

Serum Romo1, ROS, and CRP were the lowest in normal subjects and increased across OSAS severities (P < 0.05). Univariate analysis showed that serum Romo1 was positively correlated with apnea-hypopnea index (AHI), oxygen desaturation index (ODI), time spent below 90% oxygen saturation (Ts90%), arousal index, ROS, and CRP, and was negatively correlated with minimal oxygen saturation (miniSaO2) (all P < 0.05). Multiple linear regression analysis showed that serum Romo1 level was significantly associated with AHI and ODI, after adjusting for age, gender, BMI, and CRP. After 6 months of nCPAP therapy, serum Romo1, ROS, and CRP were significantly decreased (P < 0.05).

Conclusions

The increase of serum Romo1 in OSAS patients was positively correlated with disease severity. Serum Romo1 may be an important parameter for monitoring the severity of OSAS and treatment efficiency.

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Abbreviations

OSAS:

Obstructive sleep apnea syndrome

nCPAP:

Nasal continual positive airway pressure

PSG:

Polysomnography

AHI:

Apnea-hypopnea index

ODI:

Oxygen desaturation index

Ts90%:

Time spent below 90% oxygen saturation

BMI:

Body mass index

NC:

Neck circumference

Romo1:

Reactive oxygen species modulator 1

ROS:

Reactive oxygen species

CRP:

C-reactive protein

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Funding

This study was supported by the National Natural Science Foundation (No. 81601988).

Author information

Author notes

  1. Liang Ye and Yingying Qian contributed equally to this work.

Authors and Affiliations

  1. Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, No. 68, Changle Road, Qinhuai District, Nanjing, 210006, China

    Liang Ye, Yingying Qian, Qian Li, Surong Fang, Zhenhua Yang, Yan Tan & Wei Gu

Authors
  1. Liang Ye
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  2. Yingying Qian
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  3. Qian Li
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  4. Surong Fang
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  5. Zhenhua Yang
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  6. Yan Tan
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  7. Wei Gu
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Corresponding author

Correspondence to Wei Gu.

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Ethical approval

All human studies have been approved by the Ethical Committee of the Nanjing Medical University and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

All persons gave their informed consent prior to their inclusion in the study.

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Significance

We demonstrate that elevated Romo1 levels are almost universal in a cohort with obstructive sleep apnea syndrome (OSAS). Further, we observed significant, independent, positive relationships between Romo1 levels and both OSAS severity, ROS, and CRP. We also found that nCPAP treatment can effectively decrease serum Romo1 concentrations. Future investigation should focus on further clarification of the roles of Romo1 in the pathogenesis of OSAS.

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Ye, L., Qian, Y., Li, Q. et al. Serum Romo1 is significantly associated with disease severity in patients with obstructive sleep apnea syndrome. Sleep Breath 22, 743–748 (2018). https://doi.org/10.1007/s11325-017-1606-2

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  • DOI: https://doi.org/10.1007/s11325-017-1606-2

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