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Impact of FDG-PET on Prediction of Clinical Outcome after Concurrent Chemoradiotherapy in Hypopharyngeal Carcinoma

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Abstract

Purpose

To evaluate prognostic value of pretreatment and posttreatment 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) in advanced hypopharyngeal carcinoma treated by chemoradiotherapy.

Procedures

Thirty-one patients underwent a baseline FDG-PET and then FDG-PET was repeated 7 weeks after chemoradiotherapy. Primary tumor uptake of FDG, measured as the maximal standardized uptake value (SUVmax), was analyzed in relation to local control and survival.

Results

Neither local control nor cause-specific survival were associated with pretreatment SUVmax. In contrast, patients with a high posttreatment SUVmax had significantly poorer local control (P = 0.002), as well as poorer cause-specific survival (P = 0.0075), compared to those with a low posttreatment SUVmax. This prognostic significance of posttreatment SUVmax remained when only a subset of patients showing local complete response to chemoradiotherapy was analyzed.

Conclusions

Posttreatment FDG uptake represents an independent prognostic factor for hypopharyngeal carcinoma treated by chemoradiotherapy. Patients with a high posttreatment FDG uptake may benefit from adjuvant chemotherapy.

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Acknowledgement

The authors thank Masashi Furukawa for his help in statistical analysis and Rebecca Honjo for her help in editing the manuscript.

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Authors and Affiliations

  1. Department of Otolaryngology, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Hidenori Inohara, Keisuke Enomoto & Yoichiro Tomiyama

  2. Department of Nuclear Medicine and Tracer Kinetics, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Keisuke Enomoto, Ichiro Higuchi & Jun Hatazawa

  3. Department of Radiation Oncology, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Takehiro Inoue

Authors
  1. Hidenori Inohara
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  2. Keisuke Enomoto
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  3. Yoichiro Tomiyama
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  4. Ichiro Higuchi
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  5. Takehiro Inoue
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  6. Jun Hatazawa
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Corresponding author

Correspondence to Hidenori Inohara.

Additional information

Significance: This paper shows that posttreatment FDG-PET serves to identify a subset of patients with hypopharyngeal carcinoma treated by chemoradiotherapy, who are at a high risk of treatment failure.

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Inohara, H., Enomoto, K., Tomiyama, Y. et al. Impact of FDG-PET on Prediction of Clinical Outcome after Concurrent Chemoradiotherapy in Hypopharyngeal Carcinoma. Mol Imaging Biol 12, 89–97 (2010). https://doi.org/10.1007/s11307-009-0229-9

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  • DOI: https://doi.org/10.1007/s11307-009-0229-9

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