Abstract
Interest in the production of renewable chemicals from biomass has increased in the past years. Among these chemicals, carboxylic acids represent a significant part of the most desirable bio-based products. Xylonic acid is a five-carbon sugar-acid obtained from xylose oxidation that can be used in several industrial applications, including food, pharmaceutical, and construction industries. So far, the production of xylonic acid has not yet been available at an industrial scale; however, several microbial bio-based production processes are under development. This review summarizes the recent advances in pathway characterization, genetic engineering, and fermentative strategies to improve xylonic acid production by microorganisms from xylose or lignocellulosic hydrolysates. In addition, the strengths of the available microbial strains and processes and the major requirements for achieving biotechnological production of xylonic acid at a commercial scale are discussed. Efficient native and engineered microbial strains have been reported. Xylonic acid titers as high as 586 and 171 g L−1 were obtained from bacterial and yeast strains, respectively, in a laboratory medium. Furthermore, relevant academic and industrial players associated with xylonic acid production will be presented.
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We thank CAPES and CNPq for scholarships for CVGCC and DT, respectively. CNPq, FAPDF and Embrapa for financial support.
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This work was supported by CNPq, FAPDF, and Embrapa. CVGCC and DT received scholarships from CAPES and CNPq.
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DT: Data analysis, Writing and Conceptualization. CVGCC and MB: Data analysis and Writing. JRMA: Supervision, Conceptualization, Writing—review & editing, Funding acquisition.
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J.R.M.A. is coauthor of a patent that described the engineering of Komagataella phaffii for the production of xylonic acid (BR 102018001359–9). All remaining authors declare that they have no competing interests.
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Trichez, D., Carneiro, C.V.G.C., Braga, M. et al. Recent progress in the microbial production of xylonic acid. World J Microbiol Biotechnol 38, 127 (2022). https://doi.org/10.1007/s11274-022-03313-5
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DOI: https://doi.org/10.1007/s11274-022-03313-5