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Molecular characterization of VP7 gene of human rotaviruses from Bangladesh

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Abstract

This study was carried out during July 2005–June 2006, to characterize rotaviruses circulating in Bangladeshi children less than 5 years attended a peri-urban hospital. The proportion of rotavirus diarrhea was 39.5%. Genotype G2 was dominant (45.5%) followed by G1 (24.8%), G12 (9.6%), G9 (8.5%), and G4 (2.1%). G2 were mainly in combination with P[4], G1 and G9 with P[8], and G12 with P[6]. Phylogenetically Bangladeshi G1, G2, and G12 were closely related with the respective types from India, whereas Bangladeshi G9s of lineage III were with strains from Belgium and Australia. A G9 strain of lineage IV was clustered with strains from Sri Lanka and Turkey. Compared with prototype rotaviruses, Bangladeshi strains showed several amino acid substitutions at the antigenic sites of VP7. This study showed that the generation of diverse strains continued as evidenced by long G2, short G1 and G9 strains, and various combinations of G and P types.

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Social and Environmental Medicine, Institute of Scientific Research, Oita University, Yufu, Oita, Japan

    Kamruddin Ahmed

  2. Department of Paediatrics, The Institute of Child and Mother Health, Matuail, Dhaka, Bangladesh

    Selim Ahmed, Luthful Kabir & Abdul Hannan

  3. Department of Microbiology, School of Medicine, Oita University, Yufu, Oita, Japan

    Marcelo Takahiro Mitui & Akira Nishizono

  4. Centre for Injury Research and Prevention Bangladesh, Dhaka, Bangladesh

    Aminur Rahman

  5. Division of Molecular Epidemiology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Global Center of Excellence, Nagasaki University, Nagasaki, Japan

    Osamu Nakagomi

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  1. Kamruddin Ahmed
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Ahmed, K., Ahmed, S., Mitui, M.T. et al. Molecular characterization of VP7 gene of human rotaviruses from Bangladesh. Virus Genes 40, 347–356 (2010). https://doi.org/10.1007/s11262-010-0463-x

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