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Relationships Between Degree of Azotaemia and Blood Pressure, Urinary Protein:Creatinine Ratio and Fractional Excretion of Electrolytes in Dogs with Renal Azotaemia

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Abstract

Blood pressure (BP) was measured in 31 renal azotaemic dogs by oscillometric measurement at the posterior tibia artery, and urine and blood samples were collected. Haematology, blood chemistry and urinalysis were performed and urinary protein:creatinine ratio (UPC) and fractional excretions of electrolytes (FEe) were calculated. The results showed that only 19% of dogs with renal azotaemia were hypertensive, whereas almost all of them had high urinary protein and electrolyte excretions. There was no association between BP, UPC and FEe. A positive correlation was found between all pairs of electrolyte fractional excretions. When the severity of renal impairment was observed using plasma creatinine concentration, neither BP nor UPC was correlated. Only the FE e was associated with the degree of azotaemia. The results suggest that dogs with renal azotaemia do not necessarily have hypertension. The fractional urinary excretion of electrolytes may be a good indicator for severity of renal dysfunction in azotaemic dogs.

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Abbreviations

BP:

blood pressure

BUN:

blood urea nitrogen

DAP:

diastolic arterial pressure

FEK :

fractional excretion of potassium

FEMg :

fractional excretion of magnesium

FENa :

fractional excretion of sodium

GFR:

glomerular filtration rate

MAP:

mean arterial pressure

Pcr :

plasma creatinine concentration

RAA:

renin–angiotensin–aldosterone

SAP:

systolic arterial pressure

UPC:

urinary protein:creatinine ratio

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Authors and Affiliations

  1. Department of Physiology, Chulalongkorn University, Bangkok, Thailand

    C. Buranakarl, K. Ankanaporn, S. Thammacharoen, T. Maleeratmongkol, P. Thongchai & S. Panasjaroen

  2. Department of Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand

    M. Trisiriroj

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  1. C. Buranakarl
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  2. K. Ankanaporn
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  3. S. Thammacharoen
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  4. M. Trisiriroj
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  5. T. Maleeratmongkol
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  6. P. Thongchai
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  7. S. Panasjaroen
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Correspondence to C. Buranakarl.

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Buranakarl, C., Ankanaporn, K., Thammacharoen, S. et al. Relationships Between Degree of Azotaemia and Blood Pressure, Urinary Protein:Creatinine Ratio and Fractional Excretion of Electrolytes in Dogs with Renal Azotaemia. Vet Res Commun 31, 245–257 (2007). https://doi.org/10.1007/s11259-006-3413-2

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