Abstract
Objectives
Few studies have examined the quality of life of living kidney donors in mainland China. The data on anxiety and depression of living kidney donors was also scant. This study aimed to investigate quality of life, anxiety, and depression and identify their influencing factors among living kidney donors in mainland China.
Methods
A cross-sectional study included 122 living kidney donors from a kidney transplantation center in China. The abbreviated World Health Organization Quality of Life questionnaire, Generalized Anxiety Disorder 2‐item and Patient Health Questionnaire 2-item were used to assess the quality of life, anxiety and depression symptoms, respectively.
Results
Our study found that the physical related quality of life of our donors was poorer than that of the domestic general population. Among 122 donors, 43.4% and 29.5% of them were found to have anxiety and depression symptoms, respectively. Poor health condition of recipient was identified as not only negative factors affecting all domains of quality of life, but also closely related to anxiety and depression of kidney donors. Donors with proteinuria were more likely to have a poor psychological, social related quality of life, as well as anxiety and depression symptoms.
Conclusions
Living kidney donation has an impact on the physical and mental health of donors. Both the physical and mental health of living kidney donors should not be ignored. More attention and support should be given to donors with proteinuria and donors whose relative recipient suffering poor health condition.
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References
Gross CR, Messersmith EE, Hong BA, Jowsey SG, Jacobs C, Gillespie BW, Taler SJ, Matas AJ, Leichtman A, Merion RM et al (2013) Health-related quality of life in kidney donors from the last five decades: results from the RELIVE study. Am J Transplant 13:2924–2934
Keys DO, Jackson S, Berglund D, Matas AJ (2019) Kidney donor outcomes ≥ 50 years after donation. Clin Transplant 33:e13657
Thiel GT, Nolte C, Tsinalis D, Steiger J, Bachmann LM (2016) Investigating kidney donation as a risk factor for hypertension and microalbuminuria: findings from the Swiss prospective follow-up of living kidney donors. BMJ Open 6:e010869
Holscher CM, Leanza J, Thomas AG, Waldram MM, Haugen CE, Jackson KR, Bae S, Massie AB, Segev DL (2018) Anxiety, depression, and regret of donation in living kidney donors. BMC Nephrol 19:218
Nogueira JM, Weir MR, Jacobs S, Haririan A, Breault D, Klassen D, Evans D, Bartlett ST, Cooper M (2009) A study of renal outcomes in African American living kidney donors. Transplantation 88:1371–1376
Kakuta Y, Imamura R, Okumi M, Horio M, Isaka Y, Ichimaru N, Takahara S, Nonomura N, Tanabe K (2019) Assessment of renal function in living kidney donors before and after nephrectomy: a Japanese prospective, observational cohort study. Int J Urol 26:499–505
Ibrahim HN, Foley RN, Reule SA, Spong R, Kukla A, Issa N, Berglund DM, Sieger GK, Matas AJ (2016) Renal function profile in white kidney donors: the first 4 decades. J Am Soc Nephrol 27:2885–2893
Meyer KB, Hartmann A, Mjoen G, Andersen MH (2017) Relationships between clinical, self-reported, and donation specific outcomes: a prospective follow-up study 10 years after kidney donation. Ann Transplant 22:148–155
Frade IC, Fonseca I, Dias L, Henriques AC, Martins LS, Santos J, Sarmento M, Lopes A (2008) Impact assessment in living kidney donation: psychosocial aspects in the donor. Transplant Proc 40:677–681
Lopes A, Frade IC, Teixeira L, Almeida M, Dias L, Henriques AC (2013) Quality of life assessment in a living donor kidney transplantation program: evaluation of recipients and donors. Transplant Proc 45:1106–1109
Lopes A, Frade IC, Teixeira L, Oliveira C, Almeida M, Dias L, Henriques AC (2011) Depression and anxiety in living kidney donation: evaluation of donors and recipients. Transplant Proc 43:131–136
Chen P, Luo Q, Peng L (2015) Anxiety and decreased social support underline poorer quality of life of parent living kidney donors. Asia Pac Psychiatry 7:197–205
Sommerer C, Feuerstein D, Dikow R, Rauch G, Hartmann M, Schaier M, Morath C, Schwenger V, Schemmer P, Zeier M (2015) Psychosocial and physical outcome following kidney donation-a retrospective analysis. Transpl Int 28:416–428
Sommerer C, Estelmann S, Metzendorf NG, Leuschner M, Zeier M (2018) Gender disparity in health-related quality of life and fatigue after living renal donation. BMC Nephrol 19:377
Wirken L, van Middendorp H, Hooghof CW, Rovers MM, Hoitsma AJ, Hilbrands LB, Evers AW (2015) The course and predictors of health-related quality of life in living kidney donors: a systematic review and meta-analysis. Am J Transplant 15:3041–3054
Jacobs CL, Gross CR, Messersmith EE, Hong BA, Gillespie BW, Hill-Callahan P, Taler SJ, Jowsey SG, Beebe TJ, Matas AJ et al (2015) Emotional and financial experiences of kidney donors over the past 50 years: the RELIVE study. Clin J Am Soc Nephrol 10:2221–2231
Coorperative Meta-analysis Group of Working Group on Obesity in China (WGOC) (2002) Prospective study for cut-off points of body mass index in Chinese adults. Chin J Epidemiol 23:431–434
Stevens PE, Levin A, Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group M (2013) Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med 158:825–830
The WHOQOL Group (1998) Development of the World Health Organization WHOQOL-BREF quality of life assessment. Psychol Med 28:551–558
Liping M, Peng X, Haijiang L, Lahong J, Fan L (2015) Quality of life of people living with HIV/AIDS: a cross-sectional study in Zhejiang Province, China. PLoS One 10:e0135705
Jiqian F, Yuantao H, Caixia L (1999) Reliability and validity for chinese version of WHO quality of life scale. Chin Ment Health J 13:203–205
Skapinakis P (2007) The 2-item generalized anxiety disorder scale had high sensitivity and specificity for detecting GAD in primary care. Evid Based Med 12:149
Kroenke K, Spitzer RL, Williams JB (2003) The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care 41:1284–1292
Pollmann I, Gueler F, Mikuteit M, Nohre M, Richter N, Weissenborn K, de Zwaan M (2017) Adaptive personality traits and psychosocial correlates among living kidney donors. Front Psychiatry 8:210
Virzì A, Signorelli MS, Veroux M, Giammarresi G, Maugeri S, Nicoletti A, Veroux P (2007) Depression and quality of life in living related renal transplantation. Transplant Proc 39:1791–1793
Tong A, Chapman JR, Wong G, Kanellis J, McCarthy G, Craig JC (2012) The motivations and experiences of living kidney donors: a thematic synthesis. Am J Kidney Dis 60:15–26
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This work was supported by National Natural Science Foundation of China (grant number 71603272 and grant number 71974008).
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Shi, Y., Zhang, H., Nie, Z. et al. Quality of life, anxiety and depression symptoms in living related kidney donors: a cross‑sectional study. Int Urol Nephrol 55, 2335–2343 (2023). https://doi.org/10.1007/s11255-023-03542-z
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DOI: https://doi.org/10.1007/s11255-023-03542-z