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Clinicopathological characteristics and associated factors of idiopathic membranous nephropathy with hyperuricemia: a single-centered cross-sectional study

  • Nephrology - Original Paper
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Abstract

Purpose

This study was designed to investigate the clinicopathological features of idiopathic membranous nephropathy (IMN) with hyperuricemia (HUA), together with associated factors within 10 years in a single centre in Shandong Province.

Methods

In this cross-sectional study, we analysed the clinical and pathological data of 694 IMN patients in our hospital from January 2010 to December 2019. Based on serum uric acid (UA) level, the patients were divided into hyperuricemia (HUA) group (n = 213) and normal serum uric acid (NUA) group (n = 481). Multi-variate logistic regression analysis was conducted on to screen the associated factors of HUA.

Results

213 (30.69%) IMN patient were complicated with HUA. Compared with the patients with NUA, significant increase was noticed in the proportion of patients showing edema, concurrent hypertensive disease or diabetes mellitus (DM), as well as the proportion of positive glomerular capillary loop IgM and positive C1q in the HUA group (P < 0.05). In addition, significant increase was noticed in the 24 h urine protein, serum creatinine, triglycerides, complement C3 and complement C4 in HUA group compared with those of NUA group (all P < 0.05). With gender as a control factor, multi-variate logistic regression analysis showed positive glomerular capillary loops C1q, serum albumin, serum phosphorus were associated with IMN combined with HUA in male, while triglycerides and serum creatinine were associated with IMN combined with HUA in female counterparts.

Conclusion

About 30.69% of IMN patients had HUA, with a male predominance than female. In male patients with IMN, higher serum albumin level and serum phosphorus level were associated with higher incidence of HUA, while in female IMN patients, higher serum triglyceridemia and serum creatinine level were associated with higher incidence of HUA. Therefore, it can be targeted to prevent the occurrence of HUA in IMN.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This work was supported by Shandong Medicine and Health Science Technology Development Project [NO. 2017WS689], College Students’ Innovative Entrepreneurial Training Plan Program [NO. X202110440283].

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Author notes

  1. Dong Liang, Hui Zhang and Qianyu Lin contributed to this work.

Authors and Affiliations

  1. Department of Nephrology, Binzhou Medical University Hospital, Binzhou, 256600, China

    Dong Liang, Hui Zhang, Qianyu Lin, Xiuhua Wu, Min Yang, Hua Dong, Yaning Wang, Zhenmin Chen, Yunqi Liu & Xiaomin Zhang

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Contributions

LD, ZH and LQY: contributed to manuscript drafting. WXH and CZM: collected the clinical data. YM: analyzed the collected data. DH and WYN: led the renal biopsy. LYQ and ZXM: helped to write the manuscript. ZXM: supervised the entire project. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Xiaomin Zhang.

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Conflict of interest

The authors have no competing interests to declare that are relevant to the content of this article.

Ethics approval

The study protocol was consistent with the ethical principles of the Helsinki and was approved by the Ethics Committee of the Affiliated Hospital of Binzhou Medical University (Approval No.: 2021-LW-010) and individual consent for this retrospective analysis was waived.

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Liang, D., Zhang, H., Lin, Q. et al. Clinicopathological characteristics and associated factors of idiopathic membranous nephropathy with hyperuricemia: a single-centered cross-sectional study. Int Urol Nephrol 55, 2275–2283 (2023). https://doi.org/10.1007/s11255-023-03523-2

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