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Association of neutrophil-to-lymphocyte ratio with renal impairment among patients with acute gouty arthritis

  • Nephrology - Original Paper
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Abstract

Objective

Gouty arthritis (GA) is an inflammatory disease, and renal impairment may occur to varying degrees with the progress of disease. The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker. In this study, we aimed to explore the association between NLR and renal impairment in GA.

Materials and methods

The subjects comprised 499 patients with gouty arthritis (GA) (473 men, 26 women; age range, 39–61 years old) from our hospital. They were divided into a chronic kidney disease (CKD) group (n = 206) and non-CKD group (n = 293) according to the glomerular filtration rate. Blood samples were collected during the gout flares. The differences in NLR, general data, and laboratory indexes of patients with GA between the two groups were compared, such as serum uric acid (SUA), serum creatinine (SCREA), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), high-density lipoprotein (HDL), and low-density lipoprotein (LDL).

Results

NLR (3.38 vs. 2.38 (p < 0.001)) was higher in the CKD group, compared to the non-CKD group. Similarly, both SUA (527 vs. 507 (p < 0.05)) and SCREA (122 vs. 87 (p < 0.001)) were higher in the CKD group than in the non-CKD group. Multivariate logistic regression analysis showed that NLR (OR = 1.122, p < 0.05), age, hypertension, and SUA were risk factors for CKD in patients with GA, although HDL and HGB were protective factors. The receiver operating characteristic (ROC) curve analysis indicated that the area under the curve of NLR for predicting CKD in patients with GA was 0.646 (95% CI 0.597–0.694).

Conclusion

Our data showed that NLR might be an important potential factor for evaluating renal impairment in GA during flares.

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Funding

Grant of the First Affiliated Hospital of Guangzhou University of Chinese Medicine (2017QN07).

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Author notes

  1. Kai-Jun Zhu, Guo-Shu Deng and Li-Yu Zhang have equal contributions.

Authors and Affiliations

  1. Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China

    Kai-Jun Zhu, Guo-Shu Deng, Li-Yu Zhang, Ye-Chun Yang, Qiang Xu & Ming-Ying Zhang

  2. Zhengzhou Second Hospital, Zhengzhou, 450000, China

    Kai-Jun Zhu

  3. The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China

    Guo-Shu Deng, Li-Yu Zhang, Qiang Xu & Ming-Ying Zhang

Authors
  1. Kai-Jun Zhu
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  2. Guo-Shu Deng
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  3. Li-Yu Zhang
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  4. Ye-Chun Yang
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  5. Qiang Xu
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Contributions

KJZ and GSD contributed in collecting, analyzing the data and drafting the manuscript. LYZ helped collect the data. QX and MYZ conceived of the study, and participated in its design and coordination, and revised this manuscript.

Corresponding authors

Correspondence to Qiang Xu or Ming-Ying Zhang.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Zhu, KJ., Deng, GS., Zhang, LY. et al. Association of neutrophil-to-lymphocyte ratio with renal impairment among patients with acute gouty arthritis. Int Urol Nephrol 54, 2995–3000 (2022). https://doi.org/10.1007/s11255-022-03239-9

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  • DOI: https://doi.org/10.1007/s11255-022-03239-9

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