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The effect of chronic kidney disease on lipid metabolism

  • Nephrology - Review
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Abstract

The major cause of death among chronic kidney disease patients is cardiovascular diseases. Cardiovascular and kidney disease are interrelated and increase the severity of each other. Dyslipidemia is one the major causes of cardiovascular disease among chronic kidney disease patients along with diabetes and hypertension. The relationship between dyslipidemia and chronic kidney disease is reciprocal. Dyslipidemia is known to be a risk factor for chronic kidney disease and chronic kidney disease causes major alterations on lipoprotein profile, defined as the “dyslipidemic profile” of chronic kidney disease patients. Increased triglyceride, very low density lipoprotein and oxidized low density lipoprotein as well as decreased high density lipoprotein and changes in the composition of lipoproteins contribute to the “dyslipidemic profile.” Treatment strategies targeting the “dyslipidemic profile” of chronic kidney disease could contribute to prevent cardiovascular diseases. Current therapy is based on the patient kidney function and consist mainly of statins. This review focuses on the effects of chronic kidney disease on the lipoprotein profile and how this may impact novel therapeutic approaches to cardiovascular risk.

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Acknowledgements

MK gratefully acknowledges use of the services and facilities of the KoC University Research Center for Translational Medicine (KUTTAM), funded by the Republic of Turkey Ministry of Development. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Ministry of Development. AO was supported by FIS PI16/02057, ISCIII-RETIC REDinREN RD016/0009 FEDER funds, Sociedad Española de Nefrología, Fundacion Renal Iñigo Álvarez de Toledo (FRIAT), Comunidad de Madrid Biomedicina B2017/BMD-3686 CIFRA2-CM.

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This study was not funded by any Grant.

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Authors and Affiliations

  1. Department of Medicine, Koc University School of Medicine, Istanbul, Turkey

    Neris Dincer

  2. Division of Nephrology, Department of Medicine, Koc University School of Medicine, 34010, Istanbul, Turkey

    Tuncay Dagel & Mehmet Kanbay

  3. Division of Nephrology, Department of Medicine, Suleyman Demirel University School of Medicine, Isparta, Turkey

    Baris Afsar

  4. Nephrology Department, Dialysis and Renal Transplant Center, “Dr. C.I. Parhon” University Hospital, “Grigore T. Popa’’ University of Medicine and Pharmacy, Iasi, Romania

    Adrian Covic

  5. Dialysis Unit, School of Medicine, IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Avd. Reyes Católicos 2, 28040, Madrid, Spain

    Alberto Ortiz

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  1. Neris Dincer
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Dincer, N., Dagel, T., Afsar, B. et al. The effect of chronic kidney disease on lipid metabolism. Int Urol Nephrol 51, 265–277 (2019). https://doi.org/10.1007/s11255-018-2047-y

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