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A different interaction between parathyroid hormone, calcitriol and serum aluminum in chronic kidney disease; a pilot study

  • Nephrology – Original Paper
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Abstract

Background/Aims

Aluminum (Al) is an ingredient of a variety of foodstuffs and medications as well as of domestic water supplies. The patients with chronic kidney disease (CKD) are more susceptible to bone toxicity of Al. The aim of the study was to investigate the interactions between serum Al, parathyroid hormone (PTH) and active vitamin-D in CKD.

Methods

A total of 10 pediatric patients with CKD and 20 healthy controls were enrolled in study. The blood calcium, aluminum, PTH, alkaline phosphatase and phosphorus were evaluated at onset and following a regimen of oral 1,25 dihydroxycholecalciferol (1,25 DHC) for 4 weeks.

Results

Although median values of PTH, calcium, phosphorus and alkaline phosphatase did not differ (P > 0.05) after calcitriol administration, the aluminum levels (median: 27.2 ng/ml, range: 11.3–175) declined significantly (median: 3.8 ng/ml, range: 0.64–11.9) after a regimen of oral 1,25 DHC for 4 weeks in all participants (P < 0.05). The median levels of aluminum after 1,25 DHC did not show statistically significant difference with median aluminum levels of healthy controls (median: 2.5 ng/ml, range: 0.2–33.2) (P < 0.05).

Conclusion

Calcitriol may lead to decline in serum Al levels in CKD patients.

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Authors and Affiliations

  1. Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey

    Fatih Mehmet Azik

  2. Department of Pediatric Nephrology, Ankara University School of Medicine, Ankara, Turkey

    Mesiha Ekim

  3. Department of Pediatric Nephrology, Gulhane Military School of Medicine, Ankara, Turkey

    Onur Sakallioglu

  4. Department of Pharmacology, Gulhane Military School of Medicine, Ankara, Turkey

    Ahmet Aydin

  5. Cumhuriyet Bulvarı No: 333 D: 2, Alsancak, Izmir, Turkey

    Onur Sakallioglu

Authors
  1. Fatih Mehmet Azik
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  2. Mesiha Ekim
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  3. Onur Sakallioglu
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  4. Ahmet Aydin
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Correspondence to Onur Sakallioglu.

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Azik, F.M., Ekim, M., Sakallioglu, O. et al. A different interaction between parathyroid hormone, calcitriol and serum aluminum in chronic kidney disease; a pilot study. Int Urol Nephrol 43, 467–470 (2011). https://doi.org/10.1007/s11255-010-9784-x

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  • DOI: https://doi.org/10.1007/s11255-010-9784-x

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