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Towards catalytic cascade reactions: asymmetric synthesis using combined chemo-enzymatic catalysts

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The combination of immobilised Rh-MonoPhos (5-AlTUD-1) and Acylase I afforded a chemo-enzymatic one-pot process for the enantioselective synthesis of amino acids in water, without the need for isolation of intermediates. In addition, the enzymatic hydrolysis increases the enantiopurity of the product from 95% ee to >98% ee. Compatibility studies revealed that compartmentalisation of the catalysts is essential to achieve high yields and optical purities.

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Authors and Affiliations

  1. Laboratory of Biocatalysis and Organic Chemistry, Delft University of Technology, Julianalaan 136, 2628 BL, Delft, The Netherlands

    Chrétien Simons, Isabel W. C. E. Arends & Roger A. Sheldon

  2. Laboratory for Applied Organic Chemistry and Catalysis, Delft University of Technology, Julianalaan 136, 2628 BL, Delft, The Netherlands

    Chrétien Simons, Ulf Hanefeld & Thomas Maschmeyer

  3. Laboratory of Advanced Catalysis for Sustainability, School of Chemistry, University of Sydney, Sydney, NSW, 2006, Australia

    Thomas Maschmeyer

Authors
  1. Chrétien Simons
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  2. Ulf Hanefeld
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  3. Isabel W. C. E. Arends
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  4. Thomas Maschmeyer
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  5. Roger A. Sheldon
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Correspondence to Thomas Maschmeyer or Roger A. Sheldon.

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Simons, C., Hanefeld, U., Arends, I.W.C.E. et al. Towards catalytic cascade reactions: asymmetric synthesis using combined chemo-enzymatic catalysts. Top Catal 40, 35–44 (2006). https://doi.org/10.1007/s11244-006-0106-6

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