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Transition metal complexes of a hydrazone derived from hydralazine hydrochloride and 3,5-di-tert-butylsalicylaldehyde

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Abstract

Mononuclear Co(III), Ni(II) and Cu(II) coordination compounds of (E)-1-(3,5-di-tert-butyl-2-hydroxybenzylidene)-2-(phthalazin-1-yl)hydrazine (LH) were prepared and characterized by physicochemical and spectroscopic methods. The metal-to-ligand ratio was found to be 1:2 in [Co(L)2]Cl·2H2O (1) and [Ni(L)2]·2H2O (2), while it is 1:1 in [Cu(L)Cl]·2CH3OH (3). The X-ray crystal structures of LH and complex 1 is are reported. LH shows monobasic behavior, coordinating through NNO donor atoms. The complexes were investigated for their antimicrobial properties. Complexes 1 and 3 show excellent antibacterial and antifungal activities, respectively.

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Acknowledgements

Authors Sunil M. Patil, Umashri Kendur and Geeta Chimmalagi are thankful to University Grants Commission for providing UGC-UPE fellowship and Research Fellowship in Sciences for Meritorious Students (UGC-RFSMS).Thanks are due to USIC, Karnatak University, Dharwad, for spectral analysis.

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Authors and Affiliations

  1. Department of Chemistry, Karnatak University, Dharwad, Karnataka, 580003, India

    Sunil M. Patil, Umashri Kendur, Geeta Chimmalagi & Kalagouda B. Gudasi

  2. Y. B. Annigeri Pre-University Science and Commerce College, Dharwad, India

    Ramesh S. Vadavi

  3. Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research, KLE University, Belagavi, Karnataka, 590010, India

    Suneel Dodamani & Sunil Jalalpure

  4. Department of Pharmacognosy, College of Pharmacy, KLE Academy of Higher Education and Research, KLE University, Belagavi, India

    Sunil Jalalpure

  5. Brunel University London, Uxbridge, UB8 3PH, UK

    Christopher S. Frampton

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  1. Sunil M. Patil
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  2. Ramesh S. Vadavi
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  3. Suneel Dodamani
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  4. Umashri Kendur
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  8. Kalagouda B. Gudasi
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Correspondence to Kalagouda B. Gudasi.

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Patil, S.M., Vadavi, R.S., Dodamani, S. et al. Transition metal complexes of a hydrazone derived from hydralazine hydrochloride and 3,5-di-tert-butylsalicylaldehyde. Transit Met Chem 43, 65–72 (2018). https://doi.org/10.1007/s11243-017-0194-0

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  • DOI: https://doi.org/10.1007/s11243-017-0194-0

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