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Macrocyclic dinuclear nickel(II) and manganese(II) complexes: synthesis, X-ray crystal structures, DNA cleavage, and antimicrobial activity studies

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Abstract

Three dinuclear macrocyclic complexes, [Ni2L1(μ-OAc)(H2O)(CH3O)](ClO4)2·4(H2O) (1), [Mn2L2(μ-OAc) (H2O)]ClO4·H2O (2) and [Mn2L3(μ-OAc)]ClO4·H2O (3), (where H2L1, H2L2 and H2L3 are the [2 + 2] condensation products of 2,6-diformyl-4-fluorophenol with diethylenetriamine and N,N-bis(3-aminopropyl)-2-thiopheno-ethylamine, respectively), have been synthesized and characterized. The electrochemical characteristics showed that the metal centers are more electropositive when strongly electron-withdrawing groups are attached to the macrocyclic ring, and hence more easily reduced. All three complexes have been found to promote cleavage of plasmid pBR322 DNA from the supercoiled form I to the open circular form II. The antibacterial activities of the complexes were also studied.

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Acknowledgments

We are thankful for the financial support from the National Nature Science Foundation of China (21301131, 21477118), the Nature Science Foundation of Hubei Province (2013CFB313), and the Key Program of Natural Science Foundation of Hubei Province(2014CFA530).

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Authors and Affiliations

  1. Wuhan Institute of Technology, Wuhan, China

    Q. R. Cheng, L. Yu, P. Li, H. Zhou & Z. Q. Pan

  2. Engineering Research Center of Nano-Geo Materials of Ministry of Education, China University of Geosciences, Wuhan, China

    Q. R. Cheng & G. Y. Liao

Authors
  1. Q. R. Cheng
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  2. L. Yu
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  3. P. Li
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  4. G. Y. Liao
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  5. H. Zhou
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  6. Z. Q. Pan
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Corresponding authors

Correspondence to H. Zhou or Z. Q. Pan.

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Cheng, Q.R., Yu, L., Li, P. et al. Macrocyclic dinuclear nickel(II) and manganese(II) complexes: synthesis, X-ray crystal structures, DNA cleavage, and antimicrobial activity studies. Transition Met Chem 40, 789–797 (2015). https://doi.org/10.1007/s11243-015-9973-7

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  • DOI: https://doi.org/10.1007/s11243-015-9973-7

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