Abstract
The results are generalized of many-year studies into the adaptive role of heat shock proteins in different animals, including the representatives of cold- and warm-blooded species that inhabit regions with different thermal conditions. Adaptive evolution of the response to hyperthermia can lead to different results depending on the species. The thermal threshold of induction of the heat shock proteins in desert thermophylic species is, as a rule, higher than in the moderate climate species. In addition, thermoresistant species are often characterized by a certain level of heat shock proteins in cells even at a physiologically normal temperature. Although adaptation to hyperthermia is achieved in most cases without changes in the number of heat shock genes, they can be amplified in some cases in termophylic species. The role of mobile elements in evolution of the heat shock genes was shown and approach was developed for directional introduction of mutations in the promoter regions of these genes.
Similar content being viewed by others
REFERENCES
Astaurov, B.L., Iskusstvennyi partenogenez u tutovogo shelkopryada (eksperimental’noe issledovanie) (Artificial Parthenogenesis in Silkworm: An Experimental Study), Moscow: Akad. Nauk SSSR, 1940.
Craig, E.A. and Jacobsen, K., Mutations of the Heat Inducible 70 Kilodalton Genes of Yeast Confer Temperature Sensitive Growth, Cell, 1984, vol. 38, no.3, pp. 841–849.
Evgen’ev, M.B., Kolchinski, A., Levin, A., et al., Heat-Shock DNA Homology in Distantly Related Species of Drosophila, Chromosoma, 1978, vol. 68, no.4, pp. 357–365.
Evgen’ev, M.B., Zatsepina, O.G., Garbuz, D.G., et al., Evolution and Arrangement of the hsp70 Gene Cluster in Two Closely Related Species of the virilis Group of Drosophila, Chromosoma, 2004, vol. 113, pp. 223–232.
Evgen’ev, M.B., Sheinker, V.Sh., Levin, A.V., et al., Molecular Mechanisms of Adaptation to Hypothermia in Higher Organisms. 1. Synthesis of heat Shock Proteins in Cultured Cells of Various Silkworm Species and in Larvae, Molekul. Biol., 1987, vol. 21, no.2, pp. 484–494.
Feder, M.E. and Hofmann, G.E., Heat-Shock Proteins, Molecular Chaperones, and the Stress Response: Evolutionary and Ecological Physiology, Annu. Rev. Physiol., 1999, vol. 61, pp. 243–282.
Feder, M.E., Cartano, N.V., Milos, L., et al., Effect of Engineering hsp70 Copy Number on hsp70 Expression and Tolerance of Ecologically Relevant Heat Shock in Larvae and Pupae of Drosophila melanogaster, J. Exp. Biol., 1996, vol. 199, no.8, pp. 1837–1844.
Garbuz, D.G., Zatsepina, O.G., Feder, M.E., and Evgen’ev, M.B., Evolution of Thermotolerance and the Heat-Shock Response: Evidence from Inter/Intra Specific Comparison and Interspecific Hybridization in the Drosophila Virilis Species Group. I. Thermal Phenotype, J. Exp. Biol., 2003, vol. 206, pp. 2399–2408.
Gehring, J.W. and Wehner, R., Heat Shock Protein Synthesis and Thermotolerance in Cataglyphis, an Ant from the Sahara Desert, Proc. Natl. Acad. Sci. USA, 1995, vol. 92, pp. 2994–2998.
Heat Shock from Bacteria to Man, Schlesinger, M.J., Ed., New York: Cold Spring Harbor Lab, 1982.
Johnson, R.N. and Kucey, B.L., Competitive Inhibition of hsp70 Expression Causes Thermosensitivity, Science, 1988, vol. 242, pp. 1551–1554.
Kelley, W.L., The J-Domain Family and the Recruitment of Chaperone Power, Trends Biochem. Sci., 1998, vol. 23, pp. 222–227.
Krebs, R.A. and Feder, M.E., Deleterious Consequences of hsp70 Overexpression in Drosophila melanogaster Larvae, Cell Stress Chaperones, 1997, vol. 2, no.1, pp. 60–71.
Lindquist, S., The Heat-Shock Response, Annu. Rev. Biochem., 1986, vol. 55, pp. 1151–1191.
Leigh Brown, A.J. and Ish-Horowicz, D., Evolution of the 87A and 87C Heat-Shock Loci in Drosophila, Nature, 1981, vol. 290, no.5808, pp. 677–682.
Lerman, D.N., Michalak, P., Helin, A.B., et al., Modification of Heat-Shock Gene Expression in Drosophila melanogaster Populations via Transposable Elements, Mol. Biol. Evol., 2003, vol. 20, no.1, pp. 135–144.
Lyashko, V.N., Vikulova, V.K., Chernicov, V.G., et. al., Comparison of the Heat Shock Response in Ethnically and Ecologically Different Human Populations, Proc. Natl. Acad. Sci. USA, 1994, vol. 91, no.26, pp. 12 492–12 495.
Lozovskaya, E.R. and Evgen’ev, M.B., Heat Shock in Drosophila and Regulation of Genome Activity, Molekul. Biol., 1984, vol. 20, no.1, pp. 142–185.
Margulis, B.A. and Guzhova, I.V., Stress Proteins in Eukaryotic Cell, Tsitologiya, 2000, vol. 42, no.4, pp. 323–342.
Strunnikov, V.A., Sex Regulation in Practical Sericulture, Priroda, 1972, no. 7, pp. 36–47.
Timakov, B., Liu, X., Turgut, I., and Zhang, P., Timing and Targeting of P-Element Local Transposition in the Male Germline of Drosophila melanogaster, Genetics, 2002, vol. 160, pp. 1011–1022.
Ulmasov, H.A., Ovezmukhammedov, A., Karaev, K.K., and Evgen’ev, M.B., Molecular Mechanisms of Adaptation to Hypothermia in Higher Organisms. 3. Induction of Heat Shock Proteins in Two Leischmania Species, Molekul. Biol., 1988, vol. 22, no.6, pp. 1583–1589.
Ulmasov, Kh.A., Shammakov, S., Karaev, K., and Evgen’ev, M.B., Heat Shock Proteins and Thermoresistance in Lizards, Proc. Natl. Acad. Sci. USA, 1992, vol. 86, pp.1666–1670.
Ulmasov, H.A., Karaev, K.K., Lyashko, V.N., and Evgen’ev, M.B., Heat-Shock Response in Camel (Camelus dromedaries) Blood Cells and Adaptation to Hyperthermia, Comp. Biochem. Physiol. B, 1993, vol. 106, no.4, pp. 867–872.
Ulmasov, K.A., Zatsepina, O.G., Molodtsov, V.B., and Evgen’ev, M.B., Natural Body Temperature and Kinetics of Heat-Shock Protein Synthesis in the Toad-Heated Agamid Lizard Phrynocephalus interscapularis, Amphibia-Reptilia, 1999, vol. 20, pp. 1–9.
Wu, C., Heat Shock Transcription Factors: Structure and Regulation, Ann. Rev. Cell. Devel. Biol., 1995, vol. 11, pp. 441–469.
Zatsepina, O.G., Ulmasov, K.A., Beresten, S.F., et al., Thermotolerant Desert Lizards Characteristically Differ in Terms of Heat-Shock System Regulation, J. Exp. Biol., 2000, vol. 203, no.6, pp. 1017–1025.
Zatsepina, O.G., Velikodvorskaia, V.V., Molodtsov, V.B., et al., A Drosophila melanogaster Strain from Sub-Equatorial Africa Has Exceptional Thermotolerance but Decreased hsp70 Expression, J. Exp. Biol., 2001, vol. 204, no.11, pp. 1869–1881.
Author information
Authors and Affiliations
Additional information
__________
Translated from Ontogenez, Vol. 36, No. 4, 2005, pp. 265–273.
Original Russian Text Copyright © 2005 by Evgen’ev, Garbuz, Zatsepina.
Rights and permissions
About this article
Cite this article
Evgen’ev, M.B., Garbuz, D.G. & Zatsepina, O.G. Heat Shock Proteins: Functions and Role in Adaptation to Hyperthermia. Russ J Dev Biol 36, 218–224 (2005). https://doi.org/10.1007/s11174-005-0036-4
Received:
Issue Date:
DOI: https://doi.org/10.1007/s11174-005-0036-4