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Glycosylation in flow: effect of the flow rate and type of the mixer

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Russian Chemical Bulletin Aims and scope

An Erratum to this article was published on 01 December 2019

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Abstract

The influence of the flow rate and the mode of mixing of reagent solutions on the result of glycosylation of isopropyl alcohol with glycooxazoline in 1,2-dichloroethane in the presence of (±)-camphor-10-sulfonic acid was studied. No reaction products were observed at low flow rates (⩽0.043 mL h−1) when using two Comet X-01 micromixers. Under these conditions, the disaggregation of supramers of the reagents is apparently inefficient for the reaction between them to occur. However, when one of the Comet X-01 micromixers was replaced with a T-shaped adapter (at the same flow rate), the expected reaction products, glycoside and glycal, appeared in the reaction mixture. This apparently suggests a higher disaggregation of the supramers reagents under these conditions, which allows the chemical reaction between them to occur.

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  • 06 February 2020

    To the article “Glycosylation in flow: effect of the flow rate and type of the mixer,” by I. V. Myachin, A. V. Orlova, and L. O. Kononov, Vol. <Emphasis Type="Bold">68</Emphasis>, No. 11, pp. 2126–2129, November, 2019.

    In the original international version of the article, one phrase was omitted.

    To be added:

    This work was financially supported by the Russian Science Foundation (Project No. 16-13-10244-P).

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Authors and Affiliations

  1. D. I. Mendeleev University of Chemical and Technology of Russia, 9 Miusskaya pl., 125047, Moscow, Russian Federation

    I. V. Myachin

  2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    I. V. Myachin, A. V. Orlova & L. O. Kononov

  3. Moscow Physical Technical Institute, National Research University, 9 Institutsky per., 141701, Dolgoprudnyi, Moscow Region, Russian Federation

    L. O. Kononov

Authors
  1. I. V. Myachin
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  2. A. V. Orlova
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  3. L. O. Kononov
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Correspondence to L. O. Kononov.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2126–2129, November, 2019.

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Myachin, I.V., Orlova, A.V. & Kononov, L.O. Glycosylation in flow: effect of the flow rate and type of the mixer. Russ Chem Bull 68, 2126–2129 (2019). https://doi.org/10.1007/s11172-019-2677-y

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