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Synthesis and structures of CuI,II complexes with a 2,2´-bipyridine derivative bearing a (+)-3-carene moiety

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Abstract

The complex salt {[CuL2][Cu4I6]•MeCN}n (1) and the compound [Cu4L3I4]•3 MeCN (2) (L is a chiral ligand bearing a natural monoterpene (+)-3-carene moiety) were synthesized. The crystal structures of compounds 1 and 2 were determined by X-ray diffraction. The structure of compound 1 consists of complex cations [CuL2]2+ (N3O2 polyhedron is a trigonal bipyramid) and CuI coordination polymers (CuI4 polyhedron is a tetrahedron) as anions. The experimental magnetic moment μeff at 300 K is 1.90 μB, which is consistent with the X-ray diffraction data and the assumption that compound 1 is mixed-valence. The structure of compound 2 comprises a tetranuclear CuI complex, in which three Cu atoms are coordinated by two N atoms of the ligand L and two I atoms, and the fourth Cu atom is coordinated by four I atoms (coordination polyhedra are distorted tetrahedra). Compounds L and 2 were found to influence the viability of human laryngeal carcinoma cells (Hep2). The IC50 value for complex 2 (13.0±1.7 μM) is substantially smaller than IC50 for compound L (30.5±0.5 μM).

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Authors and Affiliations

  1. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 3 prosp. Akad. Lavrentieva, 630090, Novosibirsk, Russian Federation

    T. E. Kokina, L. A. Glinskaya, D. A. Piryazev, Yu. A. Eremina, D. Yu. Naumov & S. V. Larionov

  2. Novosibirsk State University, 2 ul. Pirogova, 630090, Novosibirsk, Russian Federation

    T. E. Kokina, A. Yu. Baranov, A. M. Agafontsev, Yu. A. Eremina, D. Yu. Naumov, A. V. Tkachev & S. V. Larionov

  3. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrentieva, 630090, Novosibirsk, Russian Federation

    A. Yu. Baranov, A. M. Agafontsev & A. V. Tkachev

  4. Institute of Molecular Biology and Biophysics, 2/12 ul. Timakova, 630117, Novosibirsk, Russian Federation

    E. V. Vorontsova

  5. International Tomography Center, Siberian Branch of the Russian Academy of Sciences, 3a ul. Institutskaya, 630090, Novosibirsk, Russian Federation

    A. S. Bogomyakov

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  1. T. E. Kokina
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  2. L. A. Glinskaya
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  3. D. A. Piryazev
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  4. A. Yu. Baranov
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  6. Yu. A. Eremina
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  9. D. Yu. Naumov
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  10. A. V. Tkachev
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  11. S. V. Larionov
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Corresponding author

Correspondence to T. E. Kokina.

Additional information

Based on the materials of the XXVII International Chugaev Conference on Coordination Chemistry (October 2–6, 2017; Nizhny Novgorod, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1251–1260, July, 2018.

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Kokina, T.E., Glinskaya, L.A., Piryazev, D.A. et al. Synthesis and structures of CuI,II complexes with a 2,2´-bipyridine derivative bearing a (+)-3-carene moiety. Russ Chem Bull 67, 1251–1260 (2018). https://doi.org/10.1007/s11172-018-2209-1

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  • DOI: https://doi.org/10.1007/s11172-018-2209-1

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