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Nitrosylsulfuric acid as an oxidant in the synthesis of 3,5-diarylisoxazoles

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Abstract

By six examples, it was demonstrated that nitrosylsulfuric acid can be successfully used for oxidation of 3,5-diaryl-4,5-dihydroisoxazoles to the corresponding 3,5-diarylisoxazoles. If the starting isoxazolines contain the aromatic substituents activated towards electrophilic substitution, nitration of both newly formed isoxazole and substituted benzene rings occurred.

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Authors and Affiliations

  1. Department of Chemistry, M. V. Lomonosov Moscow State University, 1 Leninskie Gory, 119992, Moscow, Russian Federation

    O. B. Bondarenko, A. I. Komarov, L. I. Kuznetsova, S. N. Nikolaeva, A. Yu. Gavrilova & N. V. Zyk

  2. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, Chernogolovka, 142432, Moscow Region, Russian Federation

    N. V. Zyk

Authors
  1. O. B. Bondarenko
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  2. A. I. Komarov
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  3. L. I. Kuznetsova
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  4. S. N. Nikolaeva
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  5. A. Yu. Gavrilova
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  6. N. V. Zyk
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Correspondence to O. B. Bondarenko.

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Dedicated to Academician of the Russian Academy of Sciences I. P. Beletskaya.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 0517—0520, March, 2018.

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Bondarenko, O.B., Komarov, A.I., Kuznetsova, L.I. et al. Nitrosylsulfuric acid as an oxidant in the synthesis of 3,5-diarylisoxazoles. Russ Chem Bull 67, 517–520 (2018). https://doi.org/10.1007/s11172-018-2103-x

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  • DOI: https://doi.org/10.1007/s11172-018-2103-x

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