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Synthesis of aromatic aldehyde acetals from (dibromomethyl)arenes

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Abstract

Zinc chloride-catalyzed double debromoalkoxylation of (dibromomethyl)arenes on treatment with trialkyl orthoformates resulted in the corresponding aromatic aldehyde acetals. On the first step, α-brominated ether is formed, which undergoes the second debromoalkoxylation producing acetal. This method is tolerated to ester functionalized derivatives.

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Authors and Affiliations

  1. Kazan National Research Technological University, 68 ul. Karl Marx, 420015, Kazan, Russian Federation

    M. B. Gazizov, S. Yu. Ivanova, N. Yu. Bashkirtseva, O. D. Khairullina, R. A. Khairullin & O. V. Gazizova

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  1. M. B. Gazizov
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  2. S. Yu. Ivanova
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  3. N. Yu. Bashkirtseva
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  4. O. D. Khairullina
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  5. R. A. Khairullin
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  6. O. V. Gazizova
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Correspondence to M. B. Gazizov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1230—1233, July, 2017.

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Gazizov, M.B., Ivanova, S.Y., Bashkirtseva, N.Y. et al. Synthesis of aromatic aldehyde acetals from (dibromomethyl)arenes. Russ Chem Bull 66, 1230–1233 (2017). https://doi.org/10.1007/s11172-017-1877-6

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  • DOI: https://doi.org/10.1007/s11172-017-1877-6

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