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Antitumor phosphate-containing lipids and non-phosphorus alkyl cationic glycerolipids: chemical structures and perspectives of drug development

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Abstract

Candidates to antitumor drugs of lipid nature are reviewed. The biological effects of the following known antineoplastic phosphate-containing lipids are described: edelfosine, ilmofosine, milfosine, perifosine, and erufosine. Although the most active phosphate-containing lipid edelfosine causes the death of tumor cells of different tissue origin, it possesses a strong hemolytic effect and toxicity toward non-malignant counterparts. The phosphate-containing lipids can be inactivated by phospholipases, which gave rise to the search for the optimum structure of cationic glycerolipids containing no phosphate group and having a similar antitumor activity. The results of structural functional studies of the non-phosphorus cationic glycerolipids with the best antitumor activity are generalized.

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Authors and Affiliations

  1. N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, 24 Kashirskoe shosse, 115478, Moscow, Russian Federation

    A. A. Markova & A. A. Shtil

  2. M. V. Lomonosov Moscow State University of Fine Chemical Technologies, 86 prosp. Vernadskogo, 119571, Moscow, Russian Federation

    N. V. Plyavnik, N. G. Morozova & M. A. Maslov

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  1. A. A. Markova
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  2. N. V. Plyavnik
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  3. N. G. Morozova
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  4. M. A. Maslov
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Correspondence to A. A. Markova.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1081–1087, May, 2014.

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Markova, A.A., Plyavnik, N.V., Morozova, N.G. et al. Antitumor phosphate-containing lipids and non-phosphorus alkyl cationic glycerolipids: chemical structures and perspectives of drug development. Russ Chem Bull 63, 1081–1087 (2014). https://doi.org/10.1007/s11172-014-0552-4

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  • DOI: https://doi.org/10.1007/s11172-014-0552-4

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