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Electrochemical method in determination of antioxidative activity using ferrocene derivatives as examples

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Abstract

Electrochemical method for the evaluation of antioxidative activity of compounds based on their reaction with the stable radical, 2,2-diphenyl-1-picrylhydrazyl, was suggested with monitoring of the reaction by cyclic voltammetry (CVA). Antioxidative properties of new ferrocene derivatives Fc(L)R (where Fc is the ferrocenyl, R is the fragment of 2,6-di-tert-butylphenol or its aromatic analog, L is the spacer) were studied. Anodic oxidation of the compounds Fc(L)R, which contain azomethine and 2,6-di-tert-butylphenol moities, proceeds in three steps, that suggests a possibility of intramolecular proton-coupled electron transfer process. Conjugates of ferrocene and 2,6-di-tert-butylphenol are efficient antioxidants.

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Authors and Affiliations

  1. Department of Chemistry, M. V. Lomonosov Moscow State University, 1 Leninskie Gory, 119992, Moscow, Russian Federation

    V. Yu. Tyurin, N. N. Meleshonkova, A. P. Glukhova & E. R. Milaeva

  2. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    A. V. Dolganov

  3. Moscow Municipal Pedagogical University, 4 2-i Sel’skokhozyaistvennyi proezd, 129226, Moscow, Russian Federation

    A. P. Glukhova

Authors
  1. V. Yu. Tyurin
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  2. N. N. Meleshonkova
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  3. A. V. Dolganov
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  4. A. P. Glukhova
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  5. E. R. Milaeva
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Correspondence to V. Yu. Tyurin.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 633–641, April, 2011.

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Tyurin, V.Y., Meleshonkova, N.N., Dolganov, A.V. et al. Electrochemical method in determination of antioxidative activity using ferrocene derivatives as examples. Russ Chem Bull 60, 647–655 (2011). https://doi.org/10.1007/s11172-011-0100-4

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  • DOI: https://doi.org/10.1007/s11172-011-0100-4

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