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Modification of biologically active amides and amines with fluorine-containing heterocycles 3*. Piracetam in the three-component reaction with methyl trifluoropyruvate and 1,3-binucleophiles

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Abstract

Three-component reaction of Piracetam, methyl trifluoropyruvate and 1,3-binucleophiles, such as 6-aminouracils, 6-aminothiouracils, 4-(4-tolylamino)pent-3-en-2-one and N-substituted ureas, has been studied. This reaction resulted in fluorinated heterocyclic derivatives of Piracetam.

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Authors and Affiliations

  1. Institute of Physiologically Active Substances, Russian Academy of Sciences, 1 Severnyi proezd, Chernogolovka, 142432, Moscow Region, Russian Federation

    V. B. Sokolov, A. Yu. Aksinenko, T. A. Epishina, T. V. Goreva & I. V. Martynov

Authors
  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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  3. T. A. Epishina
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  4. T. V. Goreva
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  5. I. V. Martynov
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Corresponding author

Correspondence to V. B. Sokolov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 281–283, January, 2010.

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Sokolov, V.B., Aksinenko, A.Y., Epishina, T.A. et al. Modification of biologically active amides and amines with fluorine-containing heterocycles 3*. Piracetam in the three-component reaction with methyl trifluoropyruvate and 1,3-binucleophiles. Russ Chem Bull 59, 288–291 (2010). https://doi.org/10.1007/s11172-010-0075-6

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  • DOI: https://doi.org/10.1007/s11172-010-0075-6

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