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Synthesis of new pyrido[2,3-d]pyrimidine derivatives by three-component condensation of 5-acetyl-4-aminopyrimidines, cyclohexane-1,3-diones, and orthocarboxylic acid esters

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Abstract

A three-component condensation of 5-acetyl-4-aminopyrimidine derivatives with dimedone (or cyclohexane-1,3-dione) and triethyl orthoacetate (or triethyl orthopropionate) gave derivatives of 7-(1,3-dioxocyclohex-2-ylidene)-7,8-dihydropyrido[2,3-d]pyrimidine. These heterocyclic compounds containing the enamino ketone fragment can form boron chelates under the action of butoxy(diphenyl)borane.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    A. V. Komkov, M. A. Prezent, A. V. Ignatenko, I. P. Yakovlev & V. A. Dorokhov

Authors
  1. A. V. Komkov
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  2. M. A. Prezent
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  3. A. V. Ignatenko
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  4. I. P. Yakovlev
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  5. V. A. Dorokhov
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Dedicated to Academician O. M. Nefedov on the occasion of his 75th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2006–2011, November, 2006.

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Komkov, A.V., Prezent, M.A., Ignatenko, A.V. et al. Synthesis of new pyrido[2,3-d]pyrimidine derivatives by three-component condensation of 5-acetyl-4-aminopyrimidines, cyclohexane-1,3-diones, and orthocarboxylic acid esters. Russ Chem Bull 55, 2085–2090 (2006). https://doi.org/10.1007/s11172-006-0552-0

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  • DOI: https://doi.org/10.1007/s11172-006-0552-0

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