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Pregna-D′-pentaranes, Progestins and Antiprogestins: II. Pathways and Realization Mechanisms of Separate Biological Functions of Steroid Hormones

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Abstract

The manner in which multifunctional steroid hormones realize their separate biological functions in mammal organisms is considered. This study is carried out on the basis of a systematic set of progesterone analogues, which we developed and described in part I of the review. This set has for the first time enabled the use of compounds of this type for studying the pathways and realization mechanisms of separate biological functions of steroid hormones. The interaction of pregna-D′-pentaranes with the classical progesterone receptor, their independent influence on the myometrium and ovogenesis, and some nonclassical effects are described. A scheme of realization is suggested for the biological functions already known, newly discovered, and presumed by us that, during pregnancy, are fulfilled in mammal organisms by progesterone and its nearest metabolite, dihydroprogesterone.

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Abbreviations

PR:

progesterone receptor

RA:

relative affinity

RCA:

relative competitive activity

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Authors and Affiliations

  1. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii pr. 47, Moscow, 119991, Russia

    A. V. Kamernitzky & I. S. Levina

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  1. A. V. Kamernitzky
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  2. I. S. Levina
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Correspondence to A. V. Kamernitzky.

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__________

Translated from Bioorganicheskaya Khimiya, Vol. 31, No. 3, 2005, pp. 227–238.

Original Russian Text Copyright © 2005 by Kamernitzky, Levina.

The Cycle of Works of the Authors Described in the Review Has Won the Shemyakin Prize in 2004

For part I, see [1].

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Kamernitzky, A.V., Levina, I.S. Pregna-D′-pentaranes, Progestins and Antiprogestins: II. Pathways and Realization Mechanisms of Separate Biological Functions of Steroid Hormones. Russ J Bioorg Chem 31, 199–209 (2005). https://doi.org/10.1007/s11171-005-0028-2

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  • DOI: https://doi.org/10.1007/s11171-005-0028-2

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