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Controlled delivery of tetracycline with TiO2@Chitosan@ZIF-8 nanocomposite and evaluation of their antimicrobial activities

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Abstract

In recent years, metal–organic frameworks (MOFs) have attracted the attention of scientists. The applications of these frameworks are gas storage and separation, electrochemical energy storage, drug delivery, catalyst, etc. In this research, a nanocarrier named TiO2@Chitosan@ZIF-8 was synthesized to deliver the antibiotic tetracycline (TC). Furthermore, the antimicrobial effect of TiO2@Chitosan@ZIF-8@TC was tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria with the best results. The structure of the nanocarrier, as well as the nanocarrier/drug, was validated by the X-ray crystallography (XRD), Fourier-transform infrared spectroscopy (FT-IR), Breuer–Emmett–Teller (BET), field emission scanning electron microscope (FE-SEM), Transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), and energy-dispersive X-ray spectroscopy (EDX/Mapping). This research indicated that 90% of the TC was encapsulated in the synthesized framework. Also, drug release was performed at pH: 5 and pH: 7.4, which revealed that 73% and 67% of TC were released in three days. It is considerable that this is the first report of the synthesizing and using a novel nanocarrier including TiO2@Chitosan@ZIF-8 with various advantages such as high surface area, high porosity, high loading percentage, and high stability.

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References

  1. R.H. Muller, C.M. Keck, J. Biotechnol. 113, 151 (2004)

    Article  CAS  Google Scholar 

  2. H.L. Ping, L. Qin, Z.D. Wang, S. Li, Res. Chem. Intermed. 38, 1421 (2012)

    Article  Google Scholar 

  3. D.K. Kim, J. Dobson, J. Mater. Chem. 19, 6294 (2009)

    Article  CAS  Google Scholar 

  4. M. Esfahanian, M.A. Ghasemzadeh, S.M.H. Razavian, Artif. Cells. Nanomed Biotechnol. 47, 2024 (2019)

    Article  CAS  Google Scholar 

  5. J. Shi, A.R. Votruba, O.C. Farokhzad, R. Langer, Nano. Lett. 10, 3223 (2010)

    Article  CAS  Google Scholar 

  6. K. Ulbrich, K. Hola, V. Subr, A. Bakandritsos, J. Tucek, R. Zboril, Chem. Rev. 116, 5338 (2016)

    Article  CAS  Google Scholar 

  7. S. Alessandro, R. Arianna, M. Javier, Adv. Chem. Eng. 57, 91 (2021)

    Article  Google Scholar 

  8. M. AL Haydar, H.R. Abid, B. Sunderland, S. Wang, Drug. Des. Devel. Ther. 11, 2685 (2017)

    Article  CAS  Google Scholar 

  9. H.D. Lawson, S.P. Walton, Ch. Chan, ACS. Appl. Mater. Interfaces 13, 7004 (2021)

    Article  CAS  Google Scholar 

  10. M. Akbari, M.A. Ghasemzadeh, M. Fadaeian, ChemistrySelect 5, 14564 (2020)

    Article  CAS  Google Scholar 

  11. S.D. Taherzade, J. Soleimannejad, A. Tarlani, Nanomaterials. 7, 215 (2017)

    Article  Google Scholar 

  12. M. Nasrabadi, M.A. Ghasemzadeh, M.R.Z. Monfared, New. J. Chem. 43, 16033 (2019)

    Article  CAS  Google Scholar 

  13. J. Gordon, H. Kazemian, S. Rohani, Mater. Sci. Eng. C. 47, 172 (2015)

    Article  CAS  Google Scholar 

  14. Q. Wang, Y. Sun, S. Li, P. Zhang, Q. Yao, RSC. Adv. 10, 37600 (2020)

    Article  CAS  Google Scholar 

  15. K. Anna, B. Joanna, T.-Z. Anita, Z. Paulina, M.-I. Anna, J. Mol. Struct. 1157, 327 (2018)

    Article  Google Scholar 

  16. S. Akinnawo, Res. J. Nanosci. Eng. 3, 10 (2019)

    Google Scholar 

  17. H. Shi, R. Magaye, V. Castranova, J. Zhao, Part. Fibre. Toxicol. 10, 15 (2013)

    Article  CAS  Google Scholar 

  18. D. Elieh-Ali-komi, M.R. Hamblin, Int J. Adv. Res. 4, 411 (2016)

    CAS  Google Scholar 

  19. D. Sahoo, S. Sahoo, P. Mohanty, S. Sasmal, P.L. Nayak, Des. Monomers. Polym. 12, 377 (2009)

    Article  CAS  Google Scholar 

  20. D.W. Lee, C. Lim, J.N. Israelachvili, D.S. Hwang, Langmuir. 29, 14222 (2013)

    Article  CAS  Google Scholar 

  21. A.M. Abdul-Kader, A. Turos, R.M. Radwan, A.M. Kelany, Appl. Surf. Sci. 255, 7786 (2009)

    Article  CAS  Google Scholar 

  22. T. Sun, L. Feng, X. Gao, L. Jiang, Acc. Chem. Res. 38, 644 (2005)

    Article  CAS  Google Scholar 

  23. A. Fujinami, D. Matsunaka, Y. Shibutani, Polymer 50, 716 (2009)

    Article  CAS  Google Scholar 

  24. D.W. Wei, W. Wei, A.C. Gauthier, J. Song, Y. Jin, H. Xiao, J. Bioresour. Bioprod. 5, 1 (2020)

    Article  CAS  Google Scholar 

  25. X. Han, X. Gong, ACS. Appl. Mater. Interfaces 13, 31298 (2021)

    Article  CAS  Google Scholar 

  26. F. Guan, Zh. Song, F. Xin, H. Wang, D. Yu, G. Li, W. Liu, J. Bioresour. Bioprod. 5, 37 (2020)

    Article  Google Scholar 

  27. I. Chopra, M. Roberts, Microbiol. Mol. Biol. Rev. 65, 232 (2001)

    Article  CAS  Google Scholar 

  28. A. Mehrizad, P. Gharbani, S.M. Tabatabii, Iran. Chem. Res. 2, 145 (2009)

    Google Scholar 

  29. R. Bakhshali-Dehkordi, M.A. Ghasemzadeh, J. Mol. Struct. 1236, 130298 (2021)

    Article  CAS  Google Scholar 

  30. Y. Zhang, Y. Jia, L. Hou, RSC. Adv. 8, 31471 (2018)

    Article  CAS  Google Scholar 

  31. P. Cervini, M. Murreli, C. Luis, F. Garcia, P. Ana, B. Ambrozini, C. Gomes, T. Eder, J. Anal. Appl. Pyrolysis. 118, 317–324 (2016)

    Article  CAS  Google Scholar 

  32. H. Moussout, H. Ahlafi, M. Aazza, M. Bourakhouadar, Polym. Degrad. Stab. 130, 1 (2016)

    Article  CAS  Google Scholar 

  33. N.A. El-Zaher, M.S. Melegy, O.W. Guirguis, Nat. Sci. 6, 859 (2014)

    Google Scholar 

  34. U. P. N, Tran, K. K. A. Le, N. T. S. Phan, ACS. Catal. 1, 120 (2011).

  35. M. Esfahanian, M.A. Ghasemzadeh, S.M.H. Razavian, Artif. Cells. Nanomed. Biotechnol. 47, 2024 (2019)

    Article  CAS  Google Scholar 

  36. M.A. Jihad, F.T.M. Noori, M.S. Jabir, S. Albukhaty, F.A. Almalki, A.A. Alyamani, Mol. 26, 3067 (2021)

    Article  CAS  Google Scholar 

  37. A.A. El-Bindary, E.A. Toson, K.R. Shoueir, H.A. Aljohani, M.M. Abo-Ser, Appl. Organomet. Chem. 34, 1 (2020)

    Article  Google Scholar 

  38. H. Nabipour, B. Soltani, N.A. Nasab, J. Am. Chem. Soc. 28, 1206 (2018)

    CAS  Google Scholar 

Download references

Acknowledgements

The present research was supported by Islamic Azad University, Qom Branch, Qom, Iran, based on grant number (2019-2898).

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Authors and Affiliations

  1. Department of Chemistry, Islamic Azad University, Qom Branch, Qom, Iran

    Mahdiyeh Akbari, Mohammad Emad Sadeghi & Mohammad Ali Ghasemzadeh

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  1. Mahdiyeh Akbari
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  2. Mohammad Emad Sadeghi
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Correspondence to Mohammad Ali Ghasemzadeh.

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Akbari, M., Sadeghi, M.E. & Ghasemzadeh, M.A. Controlled delivery of tetracycline with TiO2@Chitosan@ZIF-8 nanocomposite and evaluation of their antimicrobial activities. Res Chem Intermed 48, 3971–3985 (2022). https://doi.org/10.1007/s11164-022-04782-x

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