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Green synthesis and inhibitory effect of novel quinoline based thiazolidinones on the growth of MCF-7 human breast cancer cell line by G2/M cell cycle arrest

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Abstract

Searching for new active molecules against human breast cancer cell line MCF-7, novel quinoline based thiazolidinones has been efficiently synthesized under ultrasound irradiation. The newly synthesized compounds were tested against human breast cancer cell line MCF-7. Compounds P3, P4, and P6 were found to be promising inhibitors of MCF-7 characterized by lower IC50 values in a dose-dependent mode with high specificity against MCF-7 (IC50 of 10 μM at 24 h). Among all the synthesized compounds, P3, P4, and P6 shows IC50 values 5.38, 5.12, and 0.73 µM, respectively, were considered as a potential lead. These lead molecules showed significant anti-cancer activity against human breast cancer cell line MCF-7. Additionally, induction of G2/M cell arrest within 24 h was discovered via flow cytometry analysis. Overall, our data suggest that potent compounds have an inhibitory effect on cell proliferation of MCF-7 through cell cycle arrest, giving it great potential as a future therapeutic reagent for cancers.

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Acknowledgements

Author V.S.D. is very much grateful to the Council of Scientific and Industrial Research (CSIR), New Delhi, India, for providing Senior Research Fellowship and Sophisticated Analytical Instrumentation Facility (SAIF), Panjab University, Chandigarh for providing spectral data. We are thankful to Head, Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, for providing laboratory facility. We are thankful to Dean, School of Life Sciences, University of Hyderabad, for providing the FACS facility.

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Authors and Affiliations

  1. Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431 004, India

    Vidya S. Dofe & Charansingh H. Gill

  2. Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431 004, India

    Aniket P. Sarkate

  3. Department of Animal Biology, University of Hyderabad, Hyderabad, 500046, India

    Rajaram Azad

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  1. Vidya S. Dofe
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  2. Aniket P. Sarkate
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  3. Rajaram Azad
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  4. Charansingh H. Gill
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Correspondence to Vidya S. Dofe.

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Dofe, V.S., Sarkate, A.P., Azad, R. et al. Green synthesis and inhibitory effect of novel quinoline based thiazolidinones on the growth of MCF-7 human breast cancer cell line by G2/M cell cycle arrest. Res Chem Intermed 44, 1149–1160 (2018). https://doi.org/10.1007/s11164-017-3157-3

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