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An efficient, one-pot three components synthesis of [1,2,4] triazoloquinazolinone derivatives using anthranilic acid as green catalyst

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Abstract

A simple, efficient and convenient approach has been reported for the synthesis of quinazolines by the condensation of 3-amino, 1,2,4-triazole with dimedone and different aromatic aldehydes in the presence of anthranilic acid as a catalyst through a one-pot reaction. The high yield, at low cost, with no need of chromatographic separation, and the environmentally friendly catalyst are the prominent features of this protocol. The zwitterion of anthranilic acid plays an important role in this one-pot reaction.

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Acknowledgements

The author Sunil Vibhute is thankful to UGC, WRO, Pune for financial assistance. Authors are also grateful to Principal, Shri Shivaji Mahavidyalaya, Barshi and Instrumentation Section, Solapur University, Solapur for providing research facilities. The author PVA is thankful to RGSTC, Mumbai and Shivaji University, Kolhapur for financial assistance.

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Authors and Affiliations

  1. Chemistry Research Laboratory, Department of Chemistry, Shri Shivaji Mahavidyalaya, Barshi, Dist. Solapur, M.S, India

    Sunil Vibhute & Dattatraya Jamale

  2. Department of Chemistry, Balbhim College of Arts, Science & Commerce, Beed, Dist. Beed, M.S, India

    Santosh Undare

  3. Medicinal Chemistry Research Laboratory, Department of Chemistry, Shivaji University, Kolhapur, M.S, 416004, India

    Navanath Valekar, Govind Kolekar & Prashant Anbhule

Authors
  1. Sunil Vibhute
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  2. Dattatraya Jamale
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  3. Santosh Undare
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  4. Navanath Valekar
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  5. Govind Kolekar
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  6. Prashant Anbhule
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Corresponding author

Correspondence to Prashant Anbhule.

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Vibhute, S., Jamale, D., Undare, S. et al. An efficient, one-pot three components synthesis of [1,2,4] triazoloquinazolinone derivatives using anthranilic acid as green catalyst. Res Chem Intermed 43, 4561–4574 (2017). https://doi.org/10.1007/s11164-017-2896-5

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  • DOI: https://doi.org/10.1007/s11164-017-2896-5

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