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Anti-oxidant and antidiabetic effect of some medicinal plants belong to Terminalia species collected in Dak Lak Province, Vietnam

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Abstract

Diabetes mellitus is a chronic disease which is increasing, cannot be cured and so must be suffered for whole life. In recent years, research on herbal medicines for the treatment of diabetes has been increasing. Terminalia species have been used as traditional medicines to treat several diseases including diabetic diseases for a great many years. The aim of this study is to evaluate the anti-oxidant and antidiabetic activities of methanol extracts of the trunk-bark of three Terminalia species, T. alata, T. belirica and T. corticosa Pierre ex Laness. The anti-oxidant activity was determined by DPPH radical scavenging and the antidiabetic activity was determined by digestive enzymes inhibition and lowering fasting blood glucose in diabetic rats. The flavonoids and polyphenol contents were also determined by spectroscopic methods. The results indicated that the three trunk-bark extracts of the investigated plants possessed relatively high anti-oxidant activity with IC50 values of 0.24 mg/ml for T. alata, 1.02 mg/ml for T. belirica and 0.25 mg/ml for T. corticosa and 0.24 mg/ml for the positive control of L-ascorbic acid. In addition, these extracts also exhibited inhibitory activity on α-amylase and α-glucosidase and lowered fasting blood glucose levels in streptozotocin-induced diabetic rats but without inducing body weight loss comparing to acarbose. Amongst the extracts, the highest effect on lowering in diabetic rats was found in the extract of T. belirica followed by T. corticosa and T. alata. However, the extracts did not produce any hypoglycemic effect in normal rats at a dose up to 200 mg/kg body weight. The results suggest that the methanol extracts of the investigated plants may prove to be useful in treating type 2 diabetes.

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References

  1. C.J.A. AbrairaColwell, F.Q. Nuttall, C.T. Sawin, N.J. Nagel, J.P. Comstock, N.V. Emanuele, S.R. Levin, W. Henderson, H.S. Lee, Diabetes Care 18, 1113 (1995)

    Article  Google Scholar 

  2. P.K. Agraval, Carbon-13 NMR of flavonoids (Elsevier, New York, 1989)

  3. A. Andrade-Cetto, J. Becerra-Jiménez, R. Cárdenas-Vázquez, J. Ethnopharmacol. 116, 27 (2008)

    Article  Google Scholar 

  4. A. Bouba, Y.N. Njintang, J. Scher, C.M.F. Mbofung, Biol. J. N. Am. 1, 213 (2010)

    Google Scholar 

  5. W. Brand-Williams, M.E. Cuvelier, C. Berset, LWT Food Sci. Technol. 28, 25 (1995)

    Article  CAS  Google Scholar 

  6. T.T. Chai, F.C. Wong, J. Med. Plants Res. 6, 1730–1735 (2012)

    CAS  Google Scholar 

  7. H.Y. Cheng, T.C. Lin, K.H. Yu, C.M. Yang, C.C. Lin, Biol. Pharm. Bull. 26, 1331 (2003)

    Article  CAS  Google Scholar 

  8. R.A. DeFronzo, Ann. Intern. Med. 131, 281 (1999)

    Article  CAS  Google Scholar 

  9. O. Folin, V. Ciocalteu, J. Biol. Chem. 27, 627 (1927)

    Google Scholar 

  10. M. Gálvez, C. Martín-Cordero, P.J. Houghton, M.J. Ayuso, J. Agric. Food Chem. 23, 1927 (2005)

    Article  Google Scholar 

  11. H. Gao, H. Yi-Na, X. Pei-Yu, J. Kawabata, Food Chem. 105, 628 (2007)

    Article  CAS  Google Scholar 

  12. D.M. Gray, N. Engl. J. Med. 29, 1225 (1995)

    Google Scholar 

  13. Z. Jia, M. Tang, J. Wu, Food Chem. 64, 555 (1999)

    Article  Google Scholar 

  14. R. Klein, B.E. Klein, S.E. Moss, K.J. Cruickshanks, Intern. Med. 154, 2169 (1994)

    CAS  Google Scholar 

  15. A.J. Krentz, C.J. Bailey, Drugs 65, 385 (2005)

    Article  CAS  Google Scholar 

  16. Y.I. Kwon, H.D. Jang, K. Shetty, Asia Pac. J. Clin. Nutr. 15, 425 (2006)

    Google Scholar 

  17. Y.I. Kwon, D.A. Vattem, K. Shetty, Asia Pac. J. Clin. Nutr. 15, 107 (2006)

    Google Scholar 

  18. H.S. Lee, S.H. Jung, B.S. Yun, K.W. Lee, Arch. Toxicol. 81, 211 (2007)

    Article  CAS  Google Scholar 

  19. T.T. Mai, N.N. Thu, P.G. Tien, N. Van Chuyen, J. Nutr. Sci. Vitaminol. (Tokyo) 53(3), 267 (2007)

    Article  CAS  Google Scholar 

  20. F. Malekzadeh, H. Ehsanifar, M. Shahamat, M. Levin, R.R. Colwell, Int. J. Antimicrob. Agents 18(1), 85 (2001)

    Article  CAS  Google Scholar 

  21. T. Masuda, S. Yonemori, Y. Oyama, Y. Takeda, T. Tanaka, T. Andoh, A. Shinohara, M. Nakata, J. Agric. Food Chem. 7, 1749 (1999)

    Article  Google Scholar 

  22. G. Miliauskas, P.R. Venskutonis, T.A. Van Beek, Food Chem. 85, 231 (2004)

    Article  CAS  Google Scholar 

  23. P. Mukherjee, K. Maiti, K. Mukherjee, P.J. Houghton, J. Ethnopharmacol. 106, 1 (2006)

    Article  CAS  Google Scholar 

  24. A.N. Nagappa, P.A. Thakurdesai, N.V. Rao, J. Singh, J. Ethnopharmacol. 88, 45 (2003)

    Article  CAS  Google Scholar 

  25. S.V. Nampoothiri, A. Prathapan, O.L. Cherian, K.G. Raghu, V.V. Venugopalan, A. Sunderasan, Food Chem. Toxicol. 49, 125 (2010)

    Article  Google Scholar 

  26. Q.V. Nguyen, J.B. Eun, J. Med. Plants Res. 5(13), 2798 (2011)

    CAS  Google Scholar 

  27. Q.V. Nguyen, D.W. Kim, S.L. Wang, J.B. Eun, Res. Chem. Intermed. (2015). doi:10.1007/s11164-015-2135-x

    Google Scholar 

  28. V.B. Nguyen, Q.V. Nguyen, A.D. Nguyen, S.L. Wang, Res. Chem. Intermed. (2015). doi:10.1007/s11164-016-2434-x

  29. OECD, OECD Guidelines for Testing of Chemicals 423: Acute Oral Toxicity-Acute Toxic Class Method (OECD, Paris, 2001)

    Google Scholar 

  30. Y. Ohkubo, H. Kishikawa, E. Araki, T. Miyata, S. Isami, S. Motoyoshi, Y. Kojima, N. Furuyoshi, M. Shichiri, Diabetes Res. Clin. Pract. 28, 103 (1995)

    Article  CAS  Google Scholar 

  31. T. Ohta, S. Sasaki, T. Oohori, S. Yoshikawa, H. Kurihara, Biosci. Biotechnol. Biochem. 66,1552- 1554 (2002)

  32. K.B. Pandey, S.I. Rizvi, Curr. Nutr. Food Sci. 8, 254 (2012)

    Article  CAS  Google Scholar 

  33. B. Pfundstein, S.K. El Desouky, W.E. Hull, R. Haubner, G. Erben, R.W. Owen, Phytochem. 71(10), 1132 (2011)

    Article  Google Scholar 

  34. R. Pulido, L. Bravo, F. Saura-Calixto, J. Agric. Food Chem. 48, 3396 (2000)

    Article  CAS  Google Scholar 

  35. S. Ramachandran, K. Asokkumar, M. Uma Maheswari, T.K. Ravi, A.T. Sivashanmugam, S. Saravanan, Evid. Based Complement Altern. Med. 57, 17 (2011)

    Google Scholar 

  36. B.K. Rao, P.R. Sudarshan, M.D. Rajasekhar, N. Nagaraju, C. Appa Rao, J. Ethnopharmacol. 85, 169 (2003)

    Article  Google Scholar 

  37. S.A. Ross, E.A. Gulve, M. Wang, Chem. Rev. 104, 1255 (2004)

    Article  CAS  Google Scholar 

  38. M.C. Sabu, K. Ramadasan, J. Ethnopharmacol. 81, 155 (2002)

    Article  CAS  Google Scholar 

  39. A. Saleem, M. Ahotupa, K. Pihlaja, Z. Naturforsch. 56, 973 (2001)

    CAS  Google Scholar 

  40. A. Saleem, M. Husheem, P. Härkönen, K. Pihlaja, J. Ethnopharmacol. 81(3), 327 (2002)

    Article  CAS  Google Scholar 

  41. A.J. Scheen, N. Paquot, Diabetes Metab. 39, 179 (2013)

    Article  CAS  Google Scholar 

  42. P. Strobel, C. Allard, T. Perez-Acle, R. Calderon, R. Aldunate, F. Leighton, Biochem. J. 386, 471 (2005)

    Article  CAS  Google Scholar 

  43. X.H. Tang, L. Gao, J. Gao, Y.M. Fan, L.Z. Xu, X.N. Zhao, Q. Xu, Am. J. Chin. Med. 32, 509 (2004)

    Article  Google Scholar 

  44. A. Tiwari, J. Rao, Curr. Sci. 83, 30 (2002)

    CAS  Google Scholar 

  45. The Diabetes Control and Complications Trial Research Group, The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329, 977 (1993)

    Article  Google Scholar 

  46. V. Vats, J.K. Grover, S.S. Rathi, J. Ethnopharmacol. 79, 95 (2002)

    Article  CAS  Google Scholar 

  47. G.C. Yen, P.D. Duh, C.L. Tsai, J. Agric. Food Chem. 41, 67 (1993)

    Article  CAS  Google Scholar 

  48. J.Y. Youn, H.Y. Park, K.H. Cho, Diabetes Res. Clin. Pract. 66S, S149 (2004)

    Article  Google Scholar 

Download references

Acknowledgment

This work was supported in part by a grant from the Department of Science and Technology, Dak Lak province, Vietnam (2550/QĐ.UBND 05.12.2013).

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Authors and Affiliations

  1. Institute of Biotechnology and Environment, Tay Nguyen University, 567 Le Duan Str., Buon Ma Thuot, Dak Lak Province, Vietnam

    Quang-Vinh Nguyen, Dinh Hoang Nguyen, Thi Nhung Tran & Anh Dzung Nguyen

  2. Department of Chemistry, Tamkang University, Taipei, 251, Taiwan

    Van Bon Nguyen & San-Lang Wang

  3. Department of Natural Science and Technology, Tay Nguyen University, 567 Le Duan Str., Buon Ma Thuot, Vietnam

    Van Bon Nguyen

  4. Department of Food Science and Technology, Functional Food Research Center, College of Agriculture and Life Science, Chonnam National University, Gwangju, Korea

    Jong-Bang Eun

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  1. Quang-Vinh Nguyen
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Correspondence to Quang-Vinh Nguyen or Anh Dzung Nguyen.

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Nguyen, QV., Nguyen, V., Eun, JB. et al. Anti-oxidant and antidiabetic effect of some medicinal plants belong to Terminalia species collected in Dak Lak Province, Vietnam. Res Chem Intermed 42, 5859–5871 (2016). https://doi.org/10.1007/s11164-015-2409-3

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