Skip to main content
Log in

Bleaching earth clay pH 12.5/PEG-400 catalytic system for synthesis of some novel α, β-unsaturated ketones (chalcones)

  • Published:
Research on Chemical Intermediates Aims and scope Submit manuscript

Abstract

We report bleaching earth clay pH 12.5/PEG-400 as an efficient catalytic system for preparation of α,β-unsaturated ketones (chalcones). The method presents one or more advantages over existing methodologies such as shorter reaction time, excellent yield, and low cost. All synthesized products were characterized by spectroscopic and analytical measurements.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Scheme 1

Similar content being viewed by others

References

  1. S.N. Lopez, M.V. Castelli, S.A. Zacchino, J.N. Domıinguez, G. Lobo, J. Charris Charris, J.C.G. Cortes, J.C. Ribas, C. Devia, A.M. Rodriguez, R.D. Enriz, Bioorg. Med. Chem. 9(8), 1999 (2001)

    Article  CAS  Google Scholar 

  2. M.L. Bello, L.D. Chiaradia, L.R.S. Dias, L.K. Pacheco, T.R. Stumpf, A. Mascarello, M. Steindel, R.A. Yunes, H.C. Castro, R.J. Nunes, C.R. Rodrigues, Bioorg. Med. Chem. 19(16), 5046 (2011)

    Article  CAS  Google Scholar 

  3. A. Modzelewska, C. Pettit, G. Achanta, N.E. Davidson, P. Huang, S.R. Khan, Bioorg. Med. Chem. 14(10), 3491 (2006)

    Article  CAS  Google Scholar 

  4. X.M.L. Go, L.X. Wu, L.X. Liu, Curr. Med. Chem. 12, 483 (2005)

    Article  CAS  Google Scholar 

  5. J.R. Dimmock, D.W. Elias, M.A. Beazely, N.M. Kandepu, Curr. Med. Chem. 6, 1125 (1999)

    CAS  Google Scholar 

  6. Z. Nowakowka, Eur. J. Med. Chem. 42, 125 (2007)

    Article  Google Scholar 

  7. T. Inoue, Y. Sugimoto, H. Masuda, C. Kamei, Biol. Pharm. Bull. 25, 256 (2002)

    Article  CAS  Google Scholar 

  8. A.K. Soni, G.L.D. Krupadanam, G. Srimaunarayana, Arkivoc 16, 35 (2006)

    Article  Google Scholar 

  9. H. Yoo, S.H. Kim, J. Lee, H.J. Kim, H.S. Seo, B.Y. Chung, C. Jin, Y.S. Lee, Bull. Korean Chem. Soc. 26, 2057 (2005)

    Article  CAS  Google Scholar 

  10. G.E.A.A. Abuo-Rahma, M. Abdel-Aziz, M.A.E. Mourad, H.H. Farag, Bioorg. Med. Chem. 20(1), 195 (2012)

    Article  CAS  Google Scholar 

  11. M. Balogh, P. Laszlo, Organic Chemistry Using Clays (Springer Verlag, New York, 1993)

    Google Scholar 

  12. R.A. Sheldon, J. Dakka, Catal. Today 19, 215 (1994)

    Article  CAS  Google Scholar 

  13. A.P. Acharya, R.D. Kamble, S.D. Patil, S.V. Hese, O.S. Yemul, S.G. Patil, S.N. Halale, B.S. Dawane, Chem. Papers. 68(5), 719 (2014). doi:10.2478/s11696-013-0496-4

    Google Scholar 

  14. R.D. Kamble, G.V. Jawadwar, S.D. Patil, S.V. Hese, A.P. Acharya, B.S. Dawane, S.S. Pekamwar, Org. Commun. 6(2), 95 (2013)

    CAS  Google Scholar 

  15. A.P. Acharya, R.D. Kamble, S.D. Patil, S.V. Hese, O.S. Yemul, B.S. Dawane, Res. Chem. Intermed. (2013). doi:10.1007/s11164-013-1403-x

  16. R.D. Kamble, B.S. Dawane, O.S. Yemul, A.B. Kale, S.D. Patil, Res. Chem. Intermed. 39, 3859 (2013). doi:10.1007/s11164-012-0887-0

    Google Scholar 

  17. D. Heldebrant, P.G. Jessop, J. Am. Chem. Soc. 125, 5600 (2003)

    Article  CAS  Google Scholar 

  18. S. Chandrasekhar, Ch. Narsihmulu, S.S. Sultana, Org. Lett. 4, 4399 (2002)

    Article  CAS  Google Scholar 

  19. B.S. Dawane, S.G. Konda, G.G. Mandawad, B.M. Shaikh, Eur. J. Med. Chem. 45, 387 (2010)

    Article  CAS  Google Scholar 

  20. B.S. Dawane, B.M. Shaikh, N.T. Khandare, V.T. Kamble, S.S. Chobe, S.G. Konda, Green Chem. Lett. Rev. 3, 205 (2010)

    Article  CAS  Google Scholar 

  21. S.L. Jain, S. Singhal, B. Sain, Green Chem. 9, 740 (2007)

    Article  CAS  Google Scholar 

Download references

Acknowledgments

Financial support for this project under UGC SAP project no. F. 3-36/2011 (SAP-II) is greatly acknowledged. R.D.K. is grateful to CSIR New Delhi for a JRF.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bhaskar S. Dawane.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (PDF 68 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gaikwad, M.V., Kamble, R.D., Hese, S.V. et al. Bleaching earth clay pH 12.5/PEG-400 catalytic system for synthesis of some novel α, β-unsaturated ketones (chalcones). Res Chem Intermed 41, 4673–4678 (2015). https://doi.org/10.1007/s11164-014-1559-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11164-014-1559-z

Keywords

Navigation