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Pentafluorophenylammonium triflate as a suitable and effective metal-free catalyst for the synthesis of quinazoline derivatives via one-pot multicomponent method

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Abstract

A simple and facile synthesis of highly functionalized quinazoline derivatives has been successfully developed by treatment of aldehydes, ammonium acetate, and 2-aminoaryl ketones or isatoic anhydride under reflux conditions in the presence of a pentafluorophenylammonium triflate (PFPAT) organocatalyst. These catalytic condensation reactions represent green chemical processes, while the PFPAT organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction mixtures.

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Acknowledgment

This research is supported by the Islamic Azad University, Ayatollah Amoli Branch.

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Authors and Affiliations

  1. Chemistry Department, Islamic Azad University, Ayatollah Amoli Branch, Amol, Iran

    Samad Khaksar & Milad Gholami

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  1. Samad Khaksar
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  2. Milad Gholami
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Correspondence to Samad Khaksar.

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Khaksar, S., Gholami, M. Pentafluorophenylammonium triflate as a suitable and effective metal-free catalyst for the synthesis of quinazoline derivatives via one-pot multicomponent method. Res Chem Intermed 41, 3709–3718 (2015). https://doi.org/10.1007/s11164-013-1483-7

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  • DOI: https://doi.org/10.1007/s11164-013-1483-7

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