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Quality of life of patients and caregivers affected by bronchopulmonary dysplasia: a systematic review

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Abstract

Purpose

To synthesize evidence on the impact of bronchopulmonary dysplasia (BPD) on the Quality of Life (QoL) of affected individuals from three perspectives: (i) QoL of caregiver; (ii) caregiver’s perception of BPD patient’s QoL; and (iii) BPD patient’s self-reported QoL.

Methods

Quantitative studies (case–control, cohort, and case series) on the QoL of BPD patients or their caregivers were considered. We conducted a systematic literature search of 6 databases (PubMed, Embase, World of Science, CINAHL, PsycINFO, and Chinese National Knowledge Infrastructure) for relevant studies. All databases were searched from the date of inception of the databases to 31 March 2022. Populations of interest were caregivers with preterm babies with BPD, or children/adults who were born premature and diagnosed with BPD. The main outcome measures were total and subdomain QoL scores, and factors affecting QoL.

Results

A total of 1078 articles were found; 10 were eligible for analysis, which included 247 caregivers and 1632 patients with BPD. The QoL of patients differed by domains—some were poorer or similar, but none of the QoL domains was better than QoL of healthy controls. Poor sleep and acute care needs of BPD patients negatively affected caregiver’s QoL, while increasing illness acuity negatively affected the QoL of BPD patients. The QoL of BPD patients and their caregivers was most adversely affected during the immediate post-discharge period and tended to improve with time. The physical QoL of BPD patients was similar to that of preterm babies without BPD when assessed during late childhood and early adulthood.

Conclusion

QoL assessment should be performed as an outcome measure and incorporated in the care plan for BPD patients and their caregivers.

Systematic Review Registration PROSPERO CRD42021292253.

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Data availability

Available upon reasonable request.

Code availability

Provided in Supplementary Information.

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Acknowledgements

We thank Ms Sheena Nishanti D/O Ramasamy for providing help with manuscript submission.

Funding

The authors declare that no funds, grants, or other support was received for the preparation of this manuscript.

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Author notes

  1. Deborah Mei Xuan Lee and Ashton Kai Shun Tan are joint first authors.

Authors and Affiliations

  1. Dean’s Office, Lee Kong Chian School of Medicine, Nanyang Technological University (Novena Campus), Headquarters & Clinical Sciences Building, 11 Mandalay Road, Singapore, 308232, Singapore

    Deborah Mei Xuan Lee & Ashton Kai Shun Tan

  2. Department of Neonatology, Khoo Teck Puat-National University Children’s Medical Institute, 1E Kent Ridge Road, Level 12 NUHS Tower Block, Singapore, 119228, Singapore

    Yvonne Peng Mei Ng & Zubair Amin

  3. Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Level 12 NUHS Tower Block, Singapore, 119228, Singapore

    Yvonne Peng Mei Ng & Zubair Amin

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Contributions

All authors contributed to the study conception and design. Literature search, data extraction, and analysis were performed by Deborah M.X. Lee and Ashton K.S. Tan. The first draft of the manuscript was jointly written by Deborah M.X. Lee and Ashton K.S. Tan. All authors commented on previous versions of the manuscript and read and approved the final manuscript.

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Correspondence to Yvonne Peng Mei Ng.

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The authors have no relevant financial or non-financial interests to disclose.

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As this was a review of existing literature, ethics approval was not required.

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Lee, D.M.X., Tan, A.K.S., Ng, Y.P.M. et al. Quality of life of patients and caregivers affected by bronchopulmonary dysplasia: a systematic review. Qual Life Res 32, 1859–1869 (2023). https://doi.org/10.1007/s11136-022-03311-y

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