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Kiwifruit Peel Extract Improves the Alterations in Lipid Metabolism in High-fat Diet-fed Model Rats

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Abstract

Previous studies have demonstrated that the kiwifruit peel, which is usually discarded by consumers and factories, has the highest polyphenol content among all parts of the kiwifruit. To maximize the utilization of these waste resources, the aim of this study was to examine the regulatory effects of polyphenols extracted from kiwifruit peel (KPE) on lipid metabolism and investigate their underlying mechanisms. Thirty-two male Sprague‒Dawley rats were divided into four groups: those fed a normal diet, those fed a high-fat (HF) diet, and those fed a HF diet with a low dose of KPE solution (50 mg/kg) or a high dose of KPE (100 mg/kg) by gavage. The findings of the study revealed that KPE effectively reduced body weight gain and the increases in triglycerides and total cholesterol in serum induced by the HF diet (HFD). Additionally, KPE supplementation led to a significant decrease in hepatic fat accumulation, potentially by increasing hepatic oxidation abilities. Hepatic lipidomics demonstrated that KPE influenced various metabolic pathways, including linoleic acid metabolism, steroid biosynthesis, and the biosynthesis of unsaturated fatty acids in HFD-induced rats, which were associated with the downregulation of FATP2, ACC, FAS, GPAT, DGTA1, DGTA2, and PPARγ expression as well as the upregulation of AMPK, PGC-1α, CPT-1, and PPARα expression. These findings suggest that KPE has considerable regulatory effects in rats with dyslipidaemia, which may provide supporting information for the reuse of kiwifruit peel.

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Data Availability

The data presented in this study are available on request from the corresponding author.

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Funding

This research was funded by the National Natural Science Foundation of China (NSFC) (32060537), the Science and Technology Support Project in Guizhou Province (Qian ke he Jichu ZK [2022]360).

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Author notes

  1. Yan Zhou and Xiao Chen contributed equally to this work.

Authors and Affiliations

  1. School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, 550025, China

    Yan Zhou, Xiao Chen, Tianxia Su, Minlan Yuan & Xiaohong Sun

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  1. Yan Zhou
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  2. Xiao Chen
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  3. Tianxia Su
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  4. Minlan Yuan
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Contributions

Conceptualization, Y.Z., and X.S.; Methodology, T.S; Software, Y.Z., X.C., and T.S.; Validation, Y.Z., and X.C.; Data curation, T.S. and M.Y.; Writing-original draft preparation, Y.Z. and X.C.; Writing-review and editing, Y.Z. and X.C.; Funding acquisition, Y.Z. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Yan Zhou.

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The experimental procedures were conducted by the National Institute of Health’s Guide for the Care and Use of Laboratory Animals and approved by the Ethical Committee on Animal Research at the Guizhou Medical University (No. 1702105).

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The authors declare no competing interests.

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Zhou, Y., Chen, X., Su, T. et al. Kiwifruit Peel Extract Improves the Alterations in Lipid Metabolism in High-fat Diet-fed Model Rats. Plant Foods Hum Nutr 79, 113–119 (2024). https://doi.org/10.1007/s11130-023-01132-z

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