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Critical review of IgG4-related hypophysitis

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Abstract

Purpose

IgG4-related hypophysitis is a rare disease, with only 34 cases published in English (2015). Available short reviews may not present complete details of IgG4-related hypophysitis. We aimed to survey case reports of IgG4-related hypophysitis, including abstracts of scientific meetings, in English and Japanese.

Methods

We searched for information about IgG4-related hypophysitis in PubMed and Igakuchuozasshi (Japan Medical Abstracts Society). Among 104 case reports found, we reviewed 84 fulfilling Leporati’s diagnostic criteria.

Results

The mean ±  SD age of onset was 64.2  ±  13.9, 67.5  ±  9.8, and 56.4  ±  18.6 years for all subjects, men, and women, respectively. Men:women was 2.4:1. On magnetic resonance imaging, pituitary, stalk, and pituitary-stalk mass were observed at frequencies of 14.3, 21.4, and 64.3%, respectively. Manifestations were anterior hypopituitarism in 26.2% (22 cases), central diabetes insipidus in 17.9% (15 cases), and panhypopituitarism in 52.4% (44 cases). The median level of serum IgG4 was 264.5 mg/dL for all subjects, 405 mg/dL for men, and 226 mg/dL for women. The mean number of IgG4-related systemic diseases was 2.7  ±  1.5 in all subjects, 3.0  ±  1.5 in men, and 1.8  ±  1.1 in women. Among the IgG4-related diseases, retroperitoneal fibrosis was the most frequent (26.2%), followed by salivary gland diseases (25%). Glucocorticoid therapy was generally effective, except for two cases that received replacement doses. There were significant differences between sexes in terms of age, serum IgG4 levels, and number of IgG4-related diseases.

Conclusion

IgG4-related hypophysitis may have different clinical characteristics between genders. This survey may lack some information because the Japanese abstracts did not contain certain details.

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References

  1. Patrizio C, Shintaro I (2013) From japan with love: another tessera in the hypophysitis mosaic. J Clin Endocrinol Metab 98:1865–1868

    Article  Google Scholar 

  2. Iseda I, Hida K, Tone A, Tenta M, Shibata Y, Matsuo K, Yamadori I, Hashimoto K (2014) Prednisolone markedly reduced serum IgG4 levels along with the improvement of pituitary mass and anterior pituitary function in a patient with IgG4-related infundibulo-hypophysitis. Endocr J 61:195–203

    Article  PubMed  Google Scholar 

  3. Kanno A, Masamune A, Okazaki K, Kamisawa T, Kawa S, Nishimori I, Tsuji I, Shimosegawa T (2015) Research committee of intractable disease of the pancreas.: nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2011. Pancreas 44:535–539

    Article  PubMed  Google Scholar 

  4. Leporati P, Landek-Salgado MA, Lupi I, Chiovato L, Caturegli P (2011) IgG4-related hypophysitis: a new addition to the hypophysitis spectrum. J. Clin. Endocr. Metab. 96:1971–1980

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. van der Vliet HJ, Perenboom RM (2004) Multiple pseudotumors in IgG4-associated multifocal systemic fibrosis. Ann Intern Med 141:896–897

    Article  PubMed  Google Scholar 

  6. Wong S, Lam WY, Wong WK, Lee KC (2007) Hypophysitis presented as inflammatory pseudotumor in immunoglobulin G4-related systemic disease. Hum Pathol 38:1720–1723

    Article  PubMed  Google Scholar 

  7. Shimatsu A, Oki Y, Fujisawa I, Sano T (2009) Pituitary and stalk lesions (infundibulo-hypophysitis) associated with immunoglobulin G4-related systemic disease: an emerging clinical entity. Endocr J 56:1033–1041

    Article  PubMed  Google Scholar 

  8. Tanabe T, Tsushima K, Yasuo M, Urushihata K, Hanaoka M, Koizumi T, Fujimoto K, Kubo K, Uehara T, Shigematsu S, Hamano H, Kawa S (2006) IgG4-associated multifocal systemic fibrosis complicating sclerosing sialadenitis, hypophysitis, and retroperitoneal fibrosis, but lacking pancreatic involvement. Intern Med 45:1243–1247

    Article  PubMed  Google Scholar 

  9. Yamamoto M, Takahashi H, Ohara M, Suzuki C, Naishiro Y, Yamamoto H, Shinomura Y, Imai K (2006) A case of Mikulicz’s disease (IgG4-related plasmacytic disease) complicated by autoimmune hypophysitis. Scand J Rheumatol 35:410–411

    Article  CAS  PubMed  Google Scholar 

  10. Ralli S, Lin J, Farrell J (2007) Autoimmune pancreatitis. N. Engl. J. Med. 356:1586

    Article  CAS  PubMed  Google Scholar 

  11. Isaka Y, Yoshioka K, Nishio M, Yamagami K, Konishi Y, Inoue T, Hirano A, Hosoi M, Imanishi M (2008) A case of IgG4-related multifocal fibrosclerosis complicated by central diabetes insipidus. Endocr J 55:723–728

    Article  CAS  PubMed  Google Scholar 

  12. Tsuboi H, Inokuma S, Setoguchi K, Shuji S, Hagino N, Tanaka Y, Yoshida N, Hishima T, Kamisawa T (2008) Inflammatory pseudotumors in multiple organs associated with elevated serum IgG4 level: recovery by only a small replacement dose of steroid. Intern Med 47:1139–1142

    Article  PubMed  Google Scholar 

  13. Uehara K, Atumi H, Nakagawa J, Tachibana O, Kurose N, Nishizawa M, Fujii M, Furuya K, Tsuda S, Ito T, Nojima T, Iizuka H, Koya D (2008) A case of IgG4-related hypophysitis occured with partial diabetes inspidus and hypertrophic pachymeningitis. Nihon Naibunpi Gakkai Zasshi 84:825 (Absract; in Japanese)

    Google Scholar 

  14. Taji K, Takamura T, Mouri K, Kawano M, Akahori H, Ishikura K, Takeshita Y, Goren H, Kawano M, Takamura T, Hayashi Y, Hayashi Y, Hamada J (2009) A male case of lymphocytic hypophysitis in the course of IgG4-related disease. Nihon Naibunpi Gakkai Zasshi 85:42–44 (Absract; in Japanese)

    Google Scholar 

  15. Ando T, Hori S, Makita N, Takiyama H, Yajima Y, Sakatani T, Fukumoto S, Fujita T (2009) A case of multifocal IgG4-related systemic disease manifested as a hypophysitis, after 15 years onset of Mikulicz disease,autoimmune hepatitis and intestitial pneumonitis. In: The 564th Kanto Regional Meeting of Japan Society of Internal Medicine, p 21 (Absract; in Japanese)

  16. Takeuchi S, Takeuchi A, Takakuwa M, Akahane K, Shinoda J (2009) A case of IgG4-related hypophysitis with multiple lesions. Nihon Naibunpi Gakkai Zasshi 85:324 (in Japanese)

    Google Scholar 

  17. Fujisawa I (2009) Imaging diagnosis of lymphocytic hypophysitis and diencephalohypophysial IgG4-related disease. Folia Endocrinol Jpn 85:54–55 (in Japanese)

    Google Scholar 

  18. Osawa S, Ogawa Y, Watanabe M, Tominaga T (2009) Hypophysitis presenting with atypical rapid deterioration: with special reference to immunoglobulin G4-related disease-case report. Neurol Med Chir 49:622–625

    Article  Google Scholar 

  19. Kinoshita M, Meguro F, Kato T, Tuchida T, Baba S, Miyagi Y, Tokuyama T, Yokota N, Namba H, Oki T (2009) A case of IgG4-related hypophysitis/inflammatory pseudotumor occurred with hypopituitarism. Nihon Byori Gakkaikaishi 98:297 (Absract; in Japanese)

    Google Scholar 

  20. Tachibana O, Tukada T, Sasagawa Y, Okamoto K, Akai T, Iizuka H, Nakagawa J, Kurose N, Nojima T (2010) Pathological examination of hypophysitis in multifocal IgG4-related systemic disease “as IgG4-related hypophysitis” Nihon. Naibunpi Gakkai Zasshi 86:13–15 (in Japanese)

    Google Scholar 

  21. Hori M, Makita N, Andoh T, Takiyama H, Yajima Y, Sakatani T, Fukumoto S, Iiri T, Fujita T (2010) Long-term clinical course of IgG4-related systemic disease accompanied by hypophysitis. Endocr J 57:485–492

    Article  PubMed  Google Scholar 

  22. Haraguchi A, Era A, Yasui J, Ando T, Ueki I, Horie I, Imaizumi M, Usa T, Abe K, Origuchi T, Eguchi K (2010) Putative IgG4-related pituitary disease with hypopituitarism and/or diabetes insipidus accompanied with elevated serum levels of IgG4. Endocr J 57:719–725

    Article  CAS  PubMed  Google Scholar 

  23. Yukawa E, Nitta S, Taoka T, Morita G, Nishi S, Hara Y (2010) A patient with IgG4-related disease detected due to the presence of optic disc edema. Ganka rinsho kiyo 3:1207–1210 (in Japanese)

    Google Scholar 

  24. Yamagami K, Yoshioka K, Hosoi M (2010) A case of IgG4-related hypophysitis occurred with diabetes inspidus that was difficult to reduce prednisolone. Nihon Naibunpi Gakkai Zasshi 86:719 (Absract; in Japanese)

    Google Scholar 

  25. Okamoto K, Kuraki M, Yoda K, Yamada S, Tahara H, Goto H, Inazawa M (2010) A case of IgG4-related multifocal fibrosclerosis occurred with Diabetes inspidus and inflammatory aortic aneurysm. Nihon Naibunpi Gakkai Zasshi 86:719 (Absract; in Japanese)

    Google Scholar 

  26. Shibata N, Oki T, Oishi T, Yogo K, Yamashita M, Iino K (2010) A case of IgG4-related hypophysitis developed recurrence of pituitary enlargement after reducing prednisolone. Nihon Naibunpi Gakkai Zasshi 86:108 (Absract; in Japanese)

    Google Scholar 

  27. Kaneda M, Sagara A, Hosokawa T, Yoshimura M (2011) A case of IgG4-related multifocal fibrosclerosis occurred with central diabetes inspidus. Naika 107:175–179 (in Japanese)

    Google Scholar 

  28. Patel SM, Szostek JH (2011) IgG4-related systemic disease in a Native American man. Intern Med J 50:931–934

    Article  Google Scholar 

  29. Kotera N, Isokawa H, Uchida R, Ishimoto Y, Tanaka M, Tanaka S, Kishi S, Mise N, Sugimito T, Shiba T (2011) A case of type1 diabetes mellitis occurred with central adrenal defficiency and central diabetes inspidus associated with IgG4-related multifocal fibrosclerosis. Nihon Naika Gakkai Zasshi 100:1044–1047 (in Japanese)

    Article  PubMed  Google Scholar 

  30. Nagai K, Hara Y, Shinkai M, Goto H, Hoshino M, Watanabe K, Yamaguchi N, Kawana A, Ishigatubo Y, Kaneko T (2011) A case of IgG4-related disease with deterioration in pulmonary and pituitary involvements during a 10-year clinical course of inflammatory pseudotumor. Nihon Kokyuki Gakkai Zasshi 49:922–928 (in Japanese)

    PubMed  Google Scholar 

  31. Nanba O, Nakao K, Kawashima Y, Yuno A, Tamanaha T, Taue T, Usui K, Naruse M, Shimatsu A (2011) Two cases of IgG4-related Hypophysitis occurred with retropretitoneal fibrisis. Igaku Yakugaku 66:644 (Absract; in Japanese)

    Google Scholar 

  32. Komatsu M, Osaki K, Igarashi S, Yamashita T, Hatatani Y (2011) A case of IgG4-related hypophysitis occurred with retroperioneal fibrosis and mediastinal lymphadenopathy. Igaku Yakugaku 66:644 (Absract; in Japanese)

    Google Scholar 

  33. Kurihara A, Hamano K, Wakita Y, Danbara T, Edo N, Ohno Y, Konishi M, Morita K, Tanaka Y (2010) A case of IgG4-related hypophysitis occurred with diabetes inspidus by increasing steroid dose in the perioperative period. Nihon Naibunpi Gakkai Zasshi 86:672 (Absract; in Japanese)

    Google Scholar 

  34. Ochi K, Otuka F, Nakamura E, Tukamoto N, Takeda M, Inagaki K, Miyoshi T, Mimura Y, Ogura T, Ishida J, Ono N, Date I, Makino H (2011) A case of IgG4-related hypophysitis complicating with acute pancreatitis, diagnosed by pituitary biopsy. Nihon Naibunpi Gakkai Zasshi 87:949 (Absract; in Japanese)

    Google Scholar 

  35. Abe T, Tanioka D, Kuwajima A, Wada A (2011) A case of suspected IgG4-related hypophysitis occuring to eldery woman that was diagnosed incidentaly while investigating parotid gland tumor. Nihon Naibunpi Gakkai Zasshi 87:251 (Absract; in Japanese)

    Google Scholar 

  36. Muraoka T, Yamakado Y, Kimura H, Kurimto M, Tanabe M, Amano K, Okada Y, Ichihara A (2011) A case of Diabetes inspidus associated with IgG4-related hypophysitis. Nihon Naibunpi Gakkai Zasshi 87:364 (Absract; in Japanese)

    Google Scholar 

  37. Fujino T, Kido Y, Kaibara M, Hashimoto M, Mitokawa T, Yamawaki Y, Miyata A, Seo K (2011) A case of IgG4-related hypophysitis in the presence of central diabetes inspidus. Onomichi Shiritsu Shimin Byouin Zasshi 27:147–150 (in Japanese)

    Google Scholar 

  38. Shimazu A, Shimazu T, Nanba O, Oki T (2012) IgG4-related infundiblohypophysitis: association with autoimmune-hypothalamohypophysitis. Annu Rev Tonyobyo Taisha Naibunpi 2012:199–206 (in Japanese)

    Google Scholar 

  39. Nishina N, Kaneko Y, Kuwana M, Hanaoka H, Kameda H, Mikami S, Takeuchi T (2012) IgG4-related disease without overexpression of IgG4: pathogenesis implications. Case Rep Rheumatol 2012:1–4

    Article  Google Scholar 

  40. Nakamura Y, Hari K, Umakoshi H, Shida N, Ikezoe K (2014) A case of suspected IgG4-related hypophysitis occured with dementia. Rinsho Shinkeigaku 54:75 (Absract; in Japanese)

    Article  Google Scholar 

  41. Hamamoto K, Mishima T, Yoda M, Yoda K, Yamada S, Goto H, Furumitsu Y, Sai K, Okamura M, Inaba M (2012) A case of IgG4-related disease occured with pan-hypopituitarism while treating SLE. Nihon Naibunpi Gakkai Zasshi 88:1050 (Absract; in Japanese)

    Google Scholar 

  42. Hojo M, Ando M, Iokura Y, Arakawa Y, Chihara H, Araki Y, Funaki K, Kikuchi T, Ishikawa A, Yoshida K, Kunieda T, Takahashi J, Takagi K, Miyamoto A (2012) A diagnosis and therapy of hypophysitis. Nihon Naibunpi Gakkai Zasshi 88:75–76 (in Japanese)

    Google Scholar 

  43. Takada M, Miyoshi M, Kawano M, Ito M, Komatsu K, Tsukahara K (2012) Two cases of IgG4-related multifocal fibrosclerosis occured in urinary tract. Hinyokika Kiyo 5:613–616

    Google Scholar 

  44. Hsing MT, Hsu HT, Cheng CY, Chen CM (2013) IgG4-related hypophysitis presenting as a pituitary adenoma with systemic disease. Asian J Surg 36:93–97

    Article  PubMed  Google Scholar 

  45. Hattori Y, Tahara S, Ishii Y, Kitamura T, Inomoto C, Osamura RY, Teramoto A, Morita A (2013) A case of IgG4-related hypophysitis without pituitary insufficiency. J Clin Endocr Metab 98:1808–1811

    Article  CAS  PubMed  Google Scholar 

  46. Caputo C, Bazargan A, McKelvie PA, Sutherland T, Su CS, Warrick JI (2014) Hypophysitis due to IgG4-related disease responding to treatment with azathioprine: an alternative to corticosteroid therapy. Pituitary 17:251–256

    Article  CAS  PubMed  Google Scholar 

  47. Shiga A, Kawano T, Takiguchi T, Nagano H, Hashimoto N, Suzuki S, Koide H, Saito K, Yoshida T, Inoue N, Tanaka T, Yokote K (2013) A case of IgG4-related hypophysitis occurred with visual field defect after deliverly. Nihon Naibunpi Gakkai Zasshi 89:805 (Absract; in Japanese)

    Google Scholar 

  48. Nakamura T, Fujita M, Sakagami H, Sakai K, Arai Y, Nagashima Y, Ishizeki Y, Abiko A, MakinoY Haneda M (2014) A case of IgG4-related hypophysitis evaluated by FDG-PET. Nihon Naibunpi Gakkai Zasshi 90:21–23 (in Japanese)

    Google Scholar 

  49. Bando H, Iguchi G, Fukuoka H, Taniguchi M, Yamamoto M, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Kohmura E, Takahashi Y (2014) The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature. Eur J Endocrinol 170:161–172

    Article  CAS  PubMed  Google Scholar 

  50. Kajimoto T, Hayashi R, Sawamura M, Ohya K, Hirao R, Sachihara H (2014) A case of IgG4-related hypophysitis associated with type1 diabetes. Nihon Naibunpi Gakkai Zasshi 90:337 (Absract; in Japanese)

    Google Scholar 

  51. Tochiya M, Inagaki T, Ito T, Kobauashi T, Sato T, Kakiya S, Nagatani T, Arima H, Nakamura H, Tatematsu A (2014) A case of IgG4-related hypophysitis associated with Rathke cleft cyst involuted by a small dose of steroid therapy. Nihon Naibunpi Gakkai Zasshi 90:367 (Abstract; in Japanese)

    Google Scholar 

  52. Goda M, Naito K, Fujii T, Shimada A, Abe K, Takeda N (2014) A case of IgG4-related hypophysitis. Nihon Jibiinkoka Gakkai Kaihou 117:541 (Abstract; in Japanese)

    Article  Google Scholar 

  53. Sakai T, Kondo M, Yui S, Tomimoto H (2014) IgG4-related disease that presented cranial, cervical, lumbar and sacral hypertrophic pachymeningitis associated with infundibulo-hypophysitis. Rinsho Shinkeigaku 54:664–667 (in Japanese)

    Article  PubMed  Google Scholar 

  54. Sosa GA, Bell S, Christiansen SB, Pietrani M, Glerean M, Loto M, Lovazzano S, Carrizo A, Ajler P, Day PF (2014) Histologically confirmed isolated IgG4-related hypophysitis: two case reports in young women. Endocrinol Diabetes Metab Case Rep. doi:10.1530/EDM-14-0062

    PubMed  PubMed Central  Google Scholar 

  55. Ohkubo Y, Sekido T, Takeshige K, Ishii H, Takei M, Nishio S, Yamazaki M, Komatsu M, Kawa S, Suzuki S (2014) Occurrence of IgG4-ralated hypophysitis lacking IgG4-bearing plasma cell infiltration during steroid therapy. Intern Med J 53:753–757

    Article  Google Scholar 

  56. Masaki T, Yamagishi T, Shichiri M, Takano K, Kamata Y, Ichikawa R, Ogawa J, Kishihara E, Kaise A, Sasaki S (2014) A case of IgG4-related hypophysitis associated with aortitis diagnosed by persistent disturbance of consciousness. Nihon Naibunpi Gakkai Zasshi 90:922 (Absract; in Japanese)

    Google Scholar 

  57. Kikuno S, Nagai M, Hayashi K, Suzuki N, Takeshita A, Ishita N, Fukuhara N, Nishioka H, Yamada S, Takeuchi Y (2014) A case of IgG4-related hypophysitis infiltrated only posterior lobe. Nihon Naibunpi Gakkai Zasshi 90:922 (Absract; in Japanese)

    Google Scholar 

  58. Takahashi M, Takei S, Kawamata R, Takei G, Saito S, Sekizawa D, Nagashima S, Okada K, Komatsu K, Nagasaka S, Ishibashi S (2014) A case of suspected IgG4-related hypophysitis associated with retroperitoneal fibrosis. Nihon Naibunpi Gakkai Zasshi 90:922 (Absract; in Japanese)

    Google Scholar 

  59. Kaneko C, Yamamoto H, Shigeta M, Oguro H, Kitaoka M (2014) Two cases of IgG4-related hypophysitis diagnosed by secondory adrenal insufficiency. Nihon Naibunpi Gakkai Zasshi 90:922 (Absract; in Japanese)

    Google Scholar 

  60. Ohno Y, Yasoda A, Fujii H, Hatachi Y, Matuo K, Kanai Y, Taura D, Ogura M, Sone M, Inagaki N (2014) A case of suspeceted IgG4-related hypophysitis. Nihon Naibunpi Gakkai Zasshi 90:921 (Absract; in Japanese)

    Google Scholar 

  61. Yamashita Y, Kondo T, Ohguro Y, Kurahashi S, Tamaki N, Aki N, Kuroda A, Endo I, Kuriihara K, Matsuhisa M, Mtsumoto T (2014) A case of IgG4-related hypophysitis diagnosed by hypercarcemia. Nihon Naibunpi Gakkai Zasshi 90:922 (Absract; in Japanese)

    Google Scholar 

  62. Imber Brandon S, Lee Han S, Kunwar Sandeep, Lewis SB, Manish AK (2015) Hypophysitis: a single-center case series. Pituitary 18:630–641

    Article  PubMed  Google Scholar 

  63. Nagata T, Yanagisawa R, Shikuma J, Miwa T, Kanazawa A, Hizuka N, Odawara M (2014) A case of IgG4-related hypophysitis occured in 81 years old woman. Nihon Naibunpi Gakkai Zasshi 90:338 (Absract; in Japanese)

    Google Scholar 

  64. Mogi G, Morimoto J, Tada A, Mituishi M, Suzuki M, Suzuki Y (2015) A case of IgG4-related disease diagnosed by hypophysitis. Nihon Naibunpi Gakkai Zasshi 91:343 (Absract; in Japanese)

    Google Scholar 

  65. Jo R, Iwase K, Hisada H, Matsuura Y, Kadomatsu K, Oshima H (2015) A case of IgG4-related hypophysitis involuted by 5 days after administering steroid. Nihon Naibunpi. Gakkai Zasshi 91:343 (Absract; in Japanese)

    Google Scholar 

  66. Ono M, Ozaki Y, Morimoto R, Iwakura Y, Kudo M, Nezu M, Tezuka Y, Nakamura Y, Sasano K, Sato F (2015) A case of IgG4-related hypophysitis complicated with retroperotoneal fibrosis. Nihon Naibunpi Gakkai Zasshi 91:523 (Absract; in Japanese)

    Google Scholar 

  67. Nakasone Y, Oguchi K, Sato Y, Okubo Y, Yamauchi K (2015) Aizawa.: rapid conversion of autoimmune hypophysitis to an empty sella with immediate lowering of the serum IgG4 level. Neuroendocrinol Lett 36:112–114

    CAS  PubMed  Google Scholar 

  68. Tauziede-Espariat Arnault, Polivska Marc, Bouazza Schahrazed, Decq Phikippe, Robert Gilles, Laloi-Michelin Marie, Adle-Biassette Homa (2015) The prevalence of IgG4-positive plasma cells in hypophysitis: a possible relationship to IgG4-related disease. Clin Neuropathol 34:181–192

    Article  PubMed  Google Scholar 

  69. Harano Y, Honda K, Akiyama Y, Kotajima L, Arioka H (2015) A case of IgG4-related hypophysitis presented with hypopituitarism and diabetes inspidus. Clin Med Insights Case Rep 8:23–26

    Article  PubMed  PubMed Central  Google Scholar 

  70. Ngaosuwan K, Trongwongsa T, Shuangshoti S (2015) Clinical couase of IgG4-related hypophysitis presenting with focal seizure and replacing lymphocytic hypophysitis. BMC Endocr Disord 15:64

    Article  PubMed  PubMed Central  Google Scholar 

  71. Alexandraki KI, Kaktsatou M, Chatzellis E, Goules AV, Boutzios G, Kolomodi D, Kaltsas GA (2016) Hypophysitis in IgG4-related disease associated with p-ANCA vasculitis. Am J Med. doi:10.1016/j.amjmed.2015.11.021

    PubMed  Google Scholar 

  72. Matsuoka S, Nishiyama M, Hirano S, Nakayama S, Okazaki M, Tsugita M, Taguchi T, Taniguchi Y, Iwasaki Y, Fujimoto S, Terada N (2015) A case of IgG4-related hypophysitis occurred with central diabetes inspidus. Nihon Naibunpi Gakkai Zasshi 91:844 (Absract; in Japanese)

    Google Scholar 

  73. Nagata T, Matushita T, Kaji K, Usui T, Kobayashi T, Asahi N, Okada T, Ichiwata T, Ohno A (2015) A case of IgG4-related hypophysitis that the dry mouth atendated the appearance of stalk enlargement. Nihon Naibunpi Gakkai Zasshi 91:843 (Absract; in Japanese)

    Google Scholar 

  74. Ohtu H, Shiraishi T, Tanahashi R, Suzuki Y, Wakagi K (2015) A case of IgG4-rlated hypophysitis preceded by abdominal inflamatory pseudo tumor and pulmonary lesion. Nihon Naibunpi Gakkai Zasshi 91:843 (Absract; in Japanese)

    Google Scholar 

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Authors and Affiliations

  1. Department of Diabetology, Metabolism, and Endocrinology, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan

    Junpei Shikuma, Kenshi Kan, Rokuro Ito, Kazuo Hara, Hiroyuki Sakai, Takashi Miwa, Akira Kanazawa & Masato Odawara

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  1. Junpei Shikuma
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Shikuma, J., Kan, K., Ito, R. et al. Critical review of IgG4-related hypophysitis. Pituitary 20, 282–291 (2017). https://doi.org/10.1007/s11102-016-0773-7

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