Abstract
To describe extreme hyperprolactinemia originating from a pituitary adenoma in the wall of an ovarian dermoid. This is a description of an unusual case and a review of ectopic prolactin production. Ectopic production of prolactin is a rare condition that has been reported in isolated organ system pathology including ovaries. An ovarian dermoid is a benign neoplasm that has the potential for active unregulated endocrine function. Hyperprolactinemia can result from functioning lactotrophs found in ovarian dermoids and can lead to clinical sequelae. Definitive treatment of the condition requires surgical removal of the functioning endocrine tissue. Extreme hyperprolactinemia caused by a pituitary tumor located within a dermoid has not been reported before. We present a case of profound hyperprolactinemia originating from a pituitary adenoma found in the wall of an ovarian dermoid and give a broad overview of the condition and literature. Ectopic prolactin production should always be considered in symptomatic patients found to have elevated serum levels and no findings on brain imaging.
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References
Zalel Y, Piura B, Elchalal U et al (1996) Diagnosis and management of malignant germ cell ovarian tumors in young females. Int J Gynaecol Obstet 55:1–10
Killackey MA, Neuwirth RS (1988) Evaluation and management of the pelvic mass: a review of 540 cases. Obstet Gynecol 71:319–322
Melmed S, Casanueva FF, Hoffman AR et al (2011) Endocrine Society. Diagnosis and treatment of hyperprolactinemia: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 96:273–288
Schlechte JA (2007) Long-term management of prolactinomas. J Clin Endocrinol Metab 92:2861–2865
Turkington RW (1971) Ectopic production of prolactin. N Engl J Med 285:1455–1458
Hsu CT, Yu MH et al (1992) Ectopic production of prolactin in uterine cervical carcinoma. Gynecol Oncol 44:166–171
Akhtar M, Young I, Brody H (1975) Anterior pituitary component in benign cystic ovarian teratomas; report of three cases. Am J Clin Path 63:14–19
McKeel DW, Askin FB (1978) Ectopic hypohyseal hormonal cells in benign cystic teratoma of the ovary. Arch Pathol Lab Med 102:122–128
Wahba MH (1980) Cure of postpartum hyperprolactinemia galactorrhea–amenorrhea by removal of benign ovarian teratoma. Two case reports. Br J Obstet Gynecol 87:631–633
Axiotis CA, Lippes HA, Merino MJ et al (1987) Corticotroph cell pituitary adenoma within an ovarian teratoma. A new cause of Cushing’s syndrome. Am J Surg Pathol 11:218–224
Palmer PE, Bogojavlensky S, Bhan AK et al (1990) Prolactinoma in wall of ovarian dermoid cyst with hyperprolactinemia. Obstet Gynecol 75:540–542
Kallenberg GA, Pesce CM, Norman B et al (1990) Ectopic hyperprolactinemia resulting from an ovarian teratoma. JAMA 263:2472–2474
Papakostas GI, Miller KK, Petersen T et al (2006) Serum prolactin levels among outpatients with major depressive disorder during the acute phase of treatment with fluoxetine. J Clin Psychiatry 67:952–957
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Elms, A.F., Carlan, S.J., Rich, A.E. et al. Ovarian tumor-derived ectopic hyperprolactinemia. Pituitary 15, 552–555 (2012). https://doi.org/10.1007/s11102-011-0366-4
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DOI: https://doi.org/10.1007/s11102-011-0366-4