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Unpredictable drug reaction in a child with Cornelia de Lange syndrome

  • Case Report
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Abstract

Case description

Preoperative use of midazolam sedation is mandatory during induction of anesthesia in noncooperative and hyperactive children to prevent possible obstacles. Unusual drug reactions rarely occur in patients undergoing anesthesia or in intensive care unit. This report describes an unpredictable drug reaction after a routine midazolam premedication in a patient with no history of allergy. There has been no literature data yet to show that midazolam can provoke respiratory problems in patients with Cornelia de Lange Syndrome.

Conclusion

In our opinion midazolam should be avoided in patients with Cornelia de Lange Syndrome, which we enforced after first unpredictable reaction.

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Funding

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Author information

Authors and Affiliations

  1. Department of Anesthesia, University Children’s Hospital, Belgrade, Serbia

    Marija Stevic & Irina Milojevic

  2. Department of Minimally Invasive Surgery, Zvezdara University Clinical Hospital, Belgrade, Serbia

    Zlatko Bokun

  3. Department of Anesthesia, Medical Faculty, University of Belgrade, Belgrade, Serbia

    Dusica Simic

Authors
  1. Marija Stevic
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  2. Irina Milojevic
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  3. Zlatko Bokun
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  4. Dusica Simic
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Corresponding author

Correspondence to Marija Stevic.

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Stevic, M., Milojevic, I., Bokun, Z. et al. Unpredictable drug reaction in a child with Cornelia de Lange syndrome. Int J Clin Pharm 37, 1–3 (2015). https://doi.org/10.1007/s11096-014-0050-7

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  • DOI: https://doi.org/10.1007/s11096-014-0050-7

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