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Biomagnetic Methods: Technologies Applied to Pharmaceutical Research

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ABSTRACT

Biomagnetic methods have been designed for a wide range of applications. Recently, such methods have been proposed as alternatives to scintigraphy for evaluating of a number of pharmaceutical processes in vitro as well as under the influence of gastrointestinal physiological parameters. In this review, physical characterization as well as the most recent applications of Superconducting Quantum Interference Device (SQUID), Anisotropic Magnetoresistive (AMR) and AC Biosusceptometry (ACB) in the pharmaceutical research will be explored. Moreover, their current status and how these technologies can be employed to improve the knowledge about the impact of gastrointestinal physiology on drug delivery in association with pharmacokinetic outcomes, termed pharmacomagnetography, will be presented.

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ACKNOWLEDGEMENTS

The authors would are grateful to Brazilian Agencies CNPq and FAPESP for partial financial support.

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Authors and Affiliations

  1. Pró-Reitoria de Pesquisa e Pós-graduação - PROPEP, Universidade Estadual de Ciências da Saúde de Alagoas—UNCISAL, Maceió, AL, Brazil

    Luciana A. Corá

  2. Instituto de Ciências Biológicas e da Saúde - ICBS, Universidade Federal de Mato Grosso—UFMT, Barra do Garças, MT, Brazil

    Madileine F. Américo

  3. Departmento de Física e Biofísica—Instituto de Biociências, IBB, Universidade Estadual Paulista—UNESP, Distrito Rubiao Jr, sn, PO Box 510, Botucatu, Sao Paulo, 18600-000, Brazil

    Madileine F. Américo & José Ricardo Aruda Miranda

  4. Dep. Clínica Médica—FMRP, Universidade de São Paulo—USP, Ribeirão Preto, SP, Brazil

    Luciana A. Corá & Ricardo B. Oliveira

  5. Dep. Fármacos e Medicamentos—FCF, Universidade de São Paulo—USP, São Paulo, SP, Brazil

    Cristina H. R. Serra

  6. Dep. Física e Matemática—FCFLRP, Universidade de São Paulo—USP, Ribeirão Preto, SP, Brazil

    Oswaldo Baffa

  7. Dep. Fármacos e Medicamentos—FCFAR, Universidade Estadual Paulista—UNESP, Araraquara, SP, Brazil

    Raul C. Evangelista & Giselle F. Oliveira

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  1. Luciana A. Corá
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  8. José Ricardo Aruda Miranda
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Correspondence to José Ricardo Aruda Miranda.

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Corá, L.A., Américo, M.F., Oliveira, R.B. et al. Biomagnetic Methods: Technologies Applied to Pharmaceutical Research. Pharm Res 28, 438–455 (2011). https://doi.org/10.1007/s11095-010-0285-5

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